Ada terobosan besar dalam pengembangan obat tumor otak masa kanak-kanak. Tumor otak anak-anak adalah penyakit ganas yang lebih umum pada anak-anak. Penelitian terbaru menemukan bahwa obat koktail baru dapat mengobati tumor otak umum pada masa kanak-kanak.
Cancer Cell” magazine recently announced that in the UK, about 400 children develop brain tumor each year, of which the prevalence of boys is slightly higher than that of girls.
Are we able to take advantage of the results of tumor gene testing and tailor-made treatments, a strategy often referred to as personalized medicine? This treatment strategy can produce very good results for patients with brain tumors.
Neural myeloblastoma (medulloblastoma) is one of the most common tumor ganas of the cerebellum. This tumor otak grows rapidly and most often occurs in children around the age of 5. Pilihan pengobatan include surgery, radiation, and chemotherapy. Although great progress has been made in treatment methods and techniques, the success rate of treating myeloblastoma still lags far behind other children’s malignancies. In particular, myeloblastoma is a highly aggressive malignancy. Only 40% of patients with medulloblastoma survive, compared with other tumors of a less severe type-with a survival rate of more than 80%.
Researchers in the United States have discovered a new combination therapy for the treatment of highly aggressive neuroblastoma. In laboratory tests, the drug killed kanker cells without any toxicity to normal cells, and researchers hope to conduct clinical trials of the drug. Robert Wechsler-Reya, an adjunct professor at the Sanford Burnham Prebys Medical Institute, said: “Our goal is to confirm that the drug has low toxicity properties. Because doctors and patients in this case urgently require new clinical treatment options, we will soon apply the drug from the laboratory to clinical treatment.
Dengan menggabungkan dengan obat lain, senyawa baru yang menghambat tumor diskrining secara in vitro dan in vivo.
Uji klinis for neuroblastoma are often very challenging because of the limited number of patients. In addition, coupled with the variability of the disease, most treatments are only effective for one subtype of patient. Understanding which patients will respond to this treatment is one of the main goals of the trial.
"Jika kita dapat mengembangkan perawatan yang dibuat khusus berdasarkan gen tumor - strategi yang biasa disebut sebagai pengobatan individual - ini dapat membawa kabar baik kepada pasien dengan tumor tertentu."
Ada empat jenis neuroblastoma yang berbeda, dan pasien dengan kelompok tumor ketiga memiliki prognosis terburuk — hanya 40% pasien yang bertahan dalam jangka panjang. Sebaliknya, kelangsungan hidup jangka panjang dari neuroblastoma lain relatif optimis, dan sekitar 80% pasien dapat bertahan dalam jangka panjang.
Sebagian besar dari kelompok ketiga pasien dengan neuroblastoma memiliki ekspresi onkogen MYC yang tinggi, yang merupakan penyebab pembelahan sel yang tidak terkendali dan pembentukan tumor.
There was a study on mice with a third type of neural tube cell tumors that showed histone deacetylase inhibitors (HDACIs) and phosphatidylinositol 3-kinase inhibitors (PI3KIs) might stop mice and people from making neurotubular glioblastomas without doing too much damage to normal cells.
We found several histone deacetylase inhibitors that can kill MYC oncogene-activated neural tube cell tumors without harming normal cell agents (HDACIs),” said Pei Yanxin, an assistant professor at the National Children’s Medical Center di Washington, DC
The most effective of these compounds is panobinostat, which has entered clinical trials in other jenis kanker, but has not yet been tested on neuroblastoma.” Dr. Kun-Wei, a postdoctoral researcher at Stanford University, added: “Several other studies have revealed that the mechanism of action of panobinostat is to promote the activation of the FOXO1 gene that can interfere with the oncogenes of MYC.
Phosphatidylinositol 3-kinase inhibitors (PI3KIs) are also thought to have the effect of activating the FOXO1 gene. We hypothesized that panobinostat and phosphatidylinositol 3-kinase inhibitors (PI3KIs) could work together to block Kanker Sel bertahan hidup.
“It is true that the combined treatment of these two drugs can significantly increase the survival of patients with tumors carrying the MYC gene compared to using a single drug alone.”
