Ilmuwan Inggris memulai pengujian genetik tumor masa kanak-kanak. Ilmuwan Inggris berharap bahwa pengujian genetik akan memberi pasien yang lebih muda perawatan yang lebih baru dan lebih personal yang akan meningkatkan kelangsungan hidup mereka. Tes baru menganalisis 81 perubahan genetik kanker yang berbeda.
Scientists say the test will lead to “a higher level of playing field” and accelerate children’s access to important new drug treatments. The test was performed at the Royal Marsden National Health System Hospital in London and will be tested on 400 children from all over the UK over the next two years.
The test has been implemented with genetic funding from the National Institutes of Health (NIHR) foundation and the Kanker Institute. A charity called Christopher has provided more than £ 300,000 in funding to develop the test. The organization was founded by a couple whose children died of invasive tumor otak at the age of six.
This is a real first step towards personalized pengobatan kanker for children,” said Christopher’s parents, Karen and Kevin Capel. Christopher got a generic tumor. Hopefully, in the future, children will know exactly what type of tumor they have.” “We almost feel that the treatment for the child is not to kill the cancer, but to kill our child.”
“He used to be a healthy, happy, very athletic 4-year-old kid. But he became unable to speak or even eat on his own, and lost weight. “In the year he was diagnosed, he was unable to grow into a child of his age. We tried to keep him from other children.”
Tumor ganas sangat jarang terjadi pada anak-anak, populasi pasien tidak banyak, dan uji klinis for pharmaceutical companies will lack motivation. This means that children will miss the opportunity to receive targeted treatments for cancer cells without damaging healthy cells with innovative therapies.
Professor Louis Chesler, who is leading the genetic testing research, said: “Children often don’t have equal access to the most advanced and potentially beneficial cancer treatments.” “The cost of developing gene-targeted drugs is very high. They tend to Test it on adults first so that more people can get treatment and the results can be seen faster. ”
“Tes ini adalah kemajuan yang luar biasa karena akan dengan sangat jelas mengidentifikasi semua perubahan genetik pada tumor.” “Tes gen memberi dokter alat yang sangat ampuh — membantu mereka memilih obat yang tepat untuk anak-anak mereka dan melakukan yang terbaik. Efektifitas obat ini dapat ditentukan dengan cepat. ”
Children’s tumors are usually genetically simpler than adult tumors, so eventually these drugs may be more effective in children.” The goal of pengujian genetik is to give scientists and doctors detailed genes for childhood tumors within a few weeks of diagnosis. information.
Genetic testing gives doctors strong evidence to use terapi yang ditargetkan for younger patients, potentially preventing these patients from experiencing the side effects associated with traditional chemotherapy and radiation therapy.
Jack Daly, 14, from Wokingham, was diagnosed with a brain tumor when he was 7 and is now a brain tumor selamat. Radiotherapy helped save his life, but left him with sequelae. “My athletic ability is not very good,” Jack said. “I have to get someone to help me dress and undress at school.” “My balance is not good-I am awkward and often fall. I worked hard at school, where I found friendship.” Jack and his mother, Helen, use their donations to make ends meet in Capels-hoping that pengujian genetik will make a huge difference in the quality of life of future children.
“Orang tidak terlalu melihat masalahnya karena Jack telah sembuh dari kanker. Dia tidak perlu berada di kursi roda. Dia tidak harus memakai perban, ”kata Helen.
“Jika Anda pernah melihat Jack, dia terlihat seperti remaja laki-laki biasa. Tapi yang tidak Anda lihat adalah kerusakan jaringan otak yang disebabkan oleh pengobatan tersebut. "
URL Sumber artikel ini: http://www.bbc.com/news/health-35918744
