Los científicos británicos inician pruebas genéticas de tumores infantiles. Los científicos británicos esperan que las pruebas genéticas brinden a los pacientes más jóvenes tratamientos más nuevos y personalizados que aumentarán su supervivencia. La nueva prueba analiza 81 cambios genéticos del cáncer diferentes.
Scientists say the test will lead to “a higher level of playing field” and accelerate children’s access to important new drug treatments. The test was performed at the Royal Marsden National Health System Hospital in London and will be tested on 400 children from all over the UK over the next two years.
The test has been implemented with genetic funding from the National Institutes of Health (NIHR) foundation and the Cáncer Institute. A charity called Christopher has provided more than £ 300,000 in funding to develop the test. The organization was founded by a couple whose children died of invasive tumores cerebrales a la edad de seis.
This is a real first step towards personalized el tratamiento del cáncer for children,” said Christopher’s parents, Karen and Kevin Capel. Christopher got a generic tumor. Hopefully, in the future, children will know exactly what type of tumor they have.” “We almost feel that the treatment for the child is not to kill the cancer, but to kill our child.”
“He used to be a healthy, happy, very athletic 4-year-old kid. But he became unable to speak or even eat on his own, and lost weight. “In the year he was diagnosed, he was unable to grow into a child of his age. We tried to keep him from other children.”
Los tumores malignos son muy raros en los niños, no hay muchas poblaciones de pacientes y ensayos clínicos for pharmaceutical companies will lack motivation. This means that children will miss the opportunity to receive targeted treatments for cancer cells without damaging healthy cells with innovative therapies.
Professor Louis Chesler, who is leading the genetic testing research, said: “Children often don’t have equal access to the most advanced and potentially beneficial cancer treatments.” “The cost of developing gene-targeted drugs is very high. They tend to Test it on adults first so that more people can get treatment and the results can be seen faster. ”
"Esta prueba es un avance increíble porque identificará muy claramente todos los cambios genéticos en el tumor". “Las pruebas genéticas brindan a los médicos una herramienta extremadamente poderosa, ayudándolos a elegir el medicamento adecuado para sus hijos y hacer lo mejor que puedan. Puede ser posible determinar rápidamente la efectividad de estos medicamentos. "
Children’s tumors are usually genetically simpler than adult tumors, so eventually these drugs may be more effective in children.” The goal of Prueba genética is to give scientists and doctors detailed genes for childhood tumors within a few weeks of diagnosis. information.
Genetic testing gives doctors strong evidence to use terapias dirigidas for younger patients, potentially preventing these patients from experiencing the side effects associated with traditional chemotherapy and radiation therapy.
Jack Daly, 14, from Wokingham, was diagnosed with a brain tumor when he was 7 and is now a brain tumor sobreviviente. Radiotherapy helped save his life, but left him with sequelae. “My athletic ability is not very good,” Jack said. “I have to get someone to help me dress and undress at school.” “My balance is not good-I am awkward and often fall. I worked hard at school, where I found friendship.” Jack and his mother, Helen, use their donations to make ends meet in Capels-hoping that Prueba genética will make a huge difference in the quality of life of future children.
“La gente realmente no ve el problema porque Jack se ha recuperado del cáncer. No necesita estar en silla de ruedas. No tiene que usar un vendaje ”, dijo Helen.
“Si alguna vez has visto a Jack, parece un adolescente normal. Pero lo que no se ve es el daño al tejido cerebral causado por el tratamiento ".
URL de origen de este artículo: http://www.bbc.com/news/health-35918744
