Mingyang Song fra Harvard Medical School og Massachusetts General Hospital rapporterede, at efter diagnosticering af ikke-metastatisk tyktarmskræft, vil indtagelse af mere fiber reducere den specifikke dødelighed og den samlede dødelighed af tyktarmskræft. Øget fiberindtag efter diagnose kan gavne patienter med kolorektal cancer. (JAMA Oncol. Online-version 2. november 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal kræftoverlevende.
For at vurdere sammenhængen mellem fiberindtag og dødelighed omfattede undersøgelsen 1575 patienter med stadium I til III kolorektal cancer fra to potentielle kohorter; efter justering for andre potentielle kræftoverlevelsesprædiktorer blev kolorektal kræft specificitet bestemt Mortalitet og total dødelighed.
Mellem 6 måneder og 4 år efter diagnosen kolorektal kræft brugte forskerne et valideret spørgeskema om hyppigheden af at spise for at vurdere det samlede fiberindtag, mængden af fiber fra forskellige kilder og mængden af fuld hvede.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektal cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
