CAR T-Cell therapy in China


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An innovative immunotherapy called CAR T-cell treatment has seen substantial growth in China’s medical community. CAR T Cell therapy in China is progressing remarkably and has the potential to revolutionize cancer treatment. China is now a pioneer in this industry thanks to its strong regulatory framework and research infrastructure, which have fueled its development. CAR T-cell treatments have been successfully developed by a number of Chinese biopharmaceutical companies, showing encouraging results for patients with hematologic malignancies. Furthermore, China’s enormous patient population offers a special benefit for carrying out clinical trials and compiling data. China’s efforts are influencing the future of precision medicine and providing fresh hope for cancer patients all across the world as CAR T-cell treatment advances.

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CAR T-Cell therapy in China – Recent advances


CAR T Cell therapy in China - Recent advances

August 2023: Cancer patients who previously had few options now have hope because to CAR-T cell therapy, which has revolutionized the area of cancer treatment. With several clinical trials being conducted to increase the efficacy and safety of CAR-T cell therapy, China has emerged as a leader in this ground-breaking sector. These studies demonstrate the nation’s dedication to improving medical research and offering patients cutting-edge care. Currently there are more than 250 ongoing clinical trials on CAR T Cell therapy in China.

The number of CAR-T therapy trials in China surpassed those in the United States by 2018 as a result of this thriving ecosystem. As of June 2022, Chinese companies have conducted 342 clinical CAR-T trials. Malignancies of the B lineage were among the most prevalent manifestations. Two CAR-T products have commercial applications, Yescarta in June 2021 and Relma-cel in September 2021, among numerous drug candidates.

According to Frost & Sullivan, the domestic CAR-T market is projected to increase from CNY 0.2 billion in 2021 to CNY 8 billion in 2025, and then to CNY 28.9 billion in 2030, at a CAGR of 45% from 2022 to 2030. Despite the fact that the Chinese CAR-T market is still in its infancy, a robust driving force exists.

Although the two approved CAR-T products are from Sino-US joint ventures Fosun Kite and JW Terapeutics, domestic players have made breakthroughs and caught up to global players in recent years. Legend Biotech, IASO Biotherapeutics, and CARsgen Therapeutics all obtain NDA approval for their BCMA CAR-T products, establishing them as the leaders in BCMA CAR-T therapy. CD19 CAR-T products are a focus for Juventas Therapeutics, Gracell Biotechnologies, Hrain Biotechnology, ImunoPharm, Shanghai Cell Therapy Group, and numerous domestic companies. Juventas Therapeutics is the leader in Chinese CD19 CAR-T therapy now that the NMPA has accepted its NDA for CNCT19. CARsgen Therapeutics is a global leader in solid tumours, and CT041 is the first CAR-T candidate for treating solid tumours to enter Phase II clinical trials. Bioheng Biotech and BRL Biotech (Chinese: ) create new allogeneic CAR-T markets.

Latest news

The State Drug Administration (“NMPA”) has conditionally approved the product of Fosun Kite Biotechnology Co., Ltd., jointly established by Shanghai Fosun Pharmaceutical (Group) Co., Ltd. and Kite Pharma of the United States (trade name: Yikaida®) for the treatment of adult patients with large B-cell lymphoma (r/r LBCL) who failed first-line immunochemotherapy or relapsed within 12 months (“this new indication”). The formal debut of Yikaida® for second-line indication occurs at this time as well.

For the treatment of adult large B-cell lymphoma patients who did not react to first-line immunochemotherapy or who relapsed within a year of receiving it, there was previously no CAR-T cell therapy product available in China. A second-line indication was added by Fosun Kite’s Yikaida®. The drug’s approval for marketing has successfully sparked new developments in the management of adult large B-cell lymphoma, giving hope to more patients whose first-line immunochemotherapy has failed or relapsed. The first CAR-T cell therapy product to be licenced in China for this new indication is now Yikaida®.

For adult patients with relapsed or refractory multiple myeloma (RRMM) who have had at least three prior lines of therapy, including a proteasome inhibitor and an immunomodulatory drug, FUCASO is the first fully-human BCMA-directed chimeric antigen receptor (CAR) T-cell therapy.

A BCMA-directed CAR T cell treatment called FUCASO (Equecabtagene Autoleucel) uses lentivirus as a gene vector to transfect autologous T cells. A fully human scFv, CD8a hinge and transmembrane, 4-1BB-mediated co-stimulation, and CD3 activation domains are all present in the CAR.

FUCASO has showed quick and powerful efficacy as well as prolonged persistency in RRMM patients, delivering higher and deeper responses and long-term clinical benefit, based on selection and screening of the molecular structures, in vivo and in vitro evaluation. The combined development and marketing of FUCASO for the treatment of RRMM in China is the work of Innovent and IASO Bio.

The FUMANBA-1 clinical study, a multi-center phase I/II registrational clinical trial undertaken in China to assess the efficacy of equecabtagene autoleucel in patients with RRMM, was the basis for the NDA approval.

China is leading on clinical trials 

Clinical studies for CAR-T cell therapy have advanced significantly in China, where multiple eminent institutes have led ground-breaking study. These clinical trials are designed to assess the efficacy of CAR-T cell therapy in the management of solid tumours, leukaemia, and lymphoma.

CAR T Cell therapy hospital in China

Image: One of the hospital’s that runs clinical trials on Car T-cell therapy in China.

A significant study at the Peking University Cancer Hospital examined the use of CAR-T cells to treat acute lymphoblastic leukaemia (ALL) that has relapsed or is resistant to treatment. The research showed promise for CAR-T cell therapy as an effective treatment choice for patients with few other options thanks to its outstanding remission rates.

Additionally, a number of clinical trials have been conducted in China to examine the use of CAR-T cell treatment in solid tumours, a difficult condition with a historically low response to immunotherapies. These trials make use of cutting-edge techniques to increase CAR-T cell efficacy and get around the immunosuppressive tumour microenvironment.

International partnerships have contributed to the clinical trials of CAR-T cell therapy’s success in China. Chinese scholars have worked with well-known organisations all around the world to exchange knowledge and experience, advancing this discipline. Such collaborations have aided in the creation of sophisticated CAR-T cell therapies, including the investigation of combinatorial therapies and the use of cutting-edge gene-editing methods.

Chinese researchers have also been in the forefront of the development of off-the-shelf CAR-T cell products in an effort to circumvent the logistical difficulties posed by personalised CAR-T cell therapy. If successful, these universal CAR-T cell products could provide patients all over the world a more convenient and affordable therapeutic alternative.

The CAR-T cell therapy clinical trials done in China are evidence of the nation’s dedication to developing medical research and enhancing patient outcomes. These trials have the potential to change the face of cancer treatment by showing excellent outcomes in treating both haematological malignancies and solid tumours, providing new hope for patients everywhere.

The groundbreaking cancer treatment CAR T-cell therapy has attracted a lot of attention lately due to its astounding efficacy in curing some tumors. China has emerged as a global leader in the sector, achieving substantial advancements in CAR T-cell research and implementation, despite the fact that the therapy was initially discovered in the United States. CAR-T therapy is a novel form of cancer treatment using the immune system to eradicate cancer cells. Where other therapies have failed, it has occasionally been able to heal patients. This article will highlight all that you need to know about this procedure and current status of CAR T-Cell therapy in China.

The goal of CAR T-cell therapy is to specifically target cancer cells by reprogramming a patient’s T-cells, which are part of their immune system. In treating hematological malignancies, such as leukemia and lymphoma, where conventional medicines have frequently failed, this individualized therapeutic method has shown encouraging outcomes.

The development of CAR T-cell treatment in China is the result of a number of reasons. The nation’s big patient population, which offers a sizable pool of people for clinical trials and treatment, comes first. Due of the large number of patients, Chinese researchers have been able to collect extensive data and improve their methodologies.
The regulatory climate in China has also facilitated the quick development and widespread use of CAR T-cell treatments. Fast-track approval procedures have been established in the nation for novel medical technology, enabling quick review and uptake of new treatments. For Chinese patients, this has improved the accessibility and availability of CAR T-cell therapies. 
Numerous clinical trials have been done to assess the safety and efficacy of these treatments, with Chinese biotech companies and research institutions at the forefront of CAR T-cell therapy research. Notably, the Chinese biotechnology company Juno Therapeutics, working with Chinese medical facilities, has had outstanding success treating patients with B-cell acute lymphoblastic leukemia who have relapsed or are resistant to treatment.
China’s innovations in CAR T-cell treatment have had an impact on the world as well as its own people. Chinese scholars have actively shared their research and worked with international colleagues, advancing the field as a whole. Furthermore, China’s industrial prowess has allowed for the mass production of CAR T-cell therapies, increasing its accessibility and affordability for patients all around the world.
To sum up, China has become a significant actor in the creation and use of CAR T-cell therapy. The nation has advanced in this ground-breaking cancer treatment thanks to its sizable patient population, a supportive regulatory framework, and cooperative research activities. China’s position as a global leader in CAR T-cell treatment is set to grow with ongoing research and innovation, giving cancer patients there and around the world hope.


What is the scope of CAR-T Cell Therapy in China?

The use of chimeric antigen receptor (CAR) T-cell treatments in the treatment of hematological malignancies has been incredibly effective. The application of CAR T-cell treatments has grown in China over the past nine years. 

The first CAR T cell clinical studies started in 2013, and by 2017 there were more CAR T cell clinical trials than ever before. Soon after, China announced that it would provide a total of US$237 billion in funding for cell therapy businesses in 2021, which represented a huge increase in the number of clinical trials and fundamental research projects involving CAR T cells.

Strong government support, money inflow, high patient demand, a distinctive healthcare system, and the efforts of Chinese doctors and scientists all contributed to this significant surge in activity in China.

Why choose China for CAR T-Cell therapy?

CAR T Cell therapy clinical trials in China

Clinical trials and advance research

With more 350 ongoing clinical trials on CAR T-Cell therapy, China has achieved great strides. Innovative CAR T-cell therapies have been actively developed and tested by Chinese researchers and medical institutes, with a focus on both solid tumours and haematological malignancies. In terms of CAR T cell therapy developments, China has been in the vanguard, and there are numerous cutting-edge clinical trials happening there. Because of this, patients looking to access the most recent developments in CAR T cell therapy may find China to be an appealing alternative.. 

Low cost CAR T Cell therapy in China

Cost and availability

CAR T-Cell therapy cost in China is significantly lower than that in countries like US, UK, Australia, Japan, Korea and Singapore. CAR T-Cell therapy in China may cost just $ 60,000 USD. China has a comparatively high availability of CAR T cell therapy. There may be shorter treatment wait periods now that more medical facilities in China have received regulatory authorization to provide CAR T cell therapy. In addition, CAR T cell therapy is frequently less expensive in China than it is in other places, like the United States. This element may be especially important for people looking for affordable treatment choices. 

Expert oncologists in China

Expertise and experience

Due to its participation in multiple clinical trials and therapies, China has developed a significant amount of knowledge and experience in providing CAR T cell therapy. Chinese medical experts have improved their knowledge of CAR T cell therapy-related problems and their ability to manage them in order to improve patient outcomes. China offers high-quality healthcare thanks to its vast patient population, supportive infrastructure, and collected knowledge in CAR T cell therapy. 

US companies collaboration with Chinese companies for CAR T Cell therapy production

Companies in US collaborating with Chinese companies

In recent years, American businesses have begun collaborating with their Chinese counterparts to develop CAR T cell medicines. For ex. In 2015, WuXi AppTec, a Chinese contract research organisation (CRO), and Juno Therapeutics, a US-based biopharmaceutical business, partnered strategically. Chinese biopharmaceutical company Cellular Biomedicine Group worked with US biopharmaceutical company Celgene, which is now a division of Bristol-Myers Squibb. A global partnership and licence deal was made between Janssen Biotech, a pharmaceutical firm owned by Johnson & Johnson, and Legend Biotech, a business with operations in both China and the US.

How to apply for CAR T-Cell therapy in China?

Send your medical reports to or WhatsApp them to +1-213 789-56-55. Send following reports for opinion and estimate:

1) Medical summary

2) Latest blood reports

3) Biopsy

4) Latest PET Scan

5) Bone marrow biopsy (If available)

6) Any other relevant reports and scans

Once our team receives your medical reports, we analyze them and send it to hospitals that are performing CAR T-Cell therapy with that type of cancer and marker. We send reports to the concerned specialist and get his opinion. We also get estimate from the hospital on complete treatment. This helps you in planning for the entire treatment duration. 

Once you decide to visit for the treatment, we arrange for medical visa letter and other necessary documents from the hospital. We also help and guide you in applying for medical visa to the Chinese embassy. Once visa is ready we help and guide you in preparing for travel and flight tickets. We also arrange for your hotel and guest house, if required in China. Upon arrival in the city of treatment our representative will welcome you at the airport.

Our representative will arrange for doctor appointment and complete the necessary registration formalities for you. He will also help you with your hospital admission and other local help and support that are required. After the treatment is over we will arrange for your follow up consultation with the treating doctor.

Top hospitals for CAR T-Cell therapy in China

Peking University third hospital for Cilta cel therapy

Peking University Cancer Hospital

The innovative immunotherapy method known as CAR T-cell therapy has showed exceptional promise in the treatment of a variety of malignancies. Beijing, China’s Peking University Cancer Hospital has become a global leader in the development of CAR T-cell treatment. With the help of their multidisciplinary team, which consists of oncologists, immunologists, and geneticists, personalized cancer treatment has advanced significantly. Peking University Cancer Hospital has obtained outstanding outcomes in patients with haematological malignancies by altering patients’ own T cells to express chimeric antigen receptors (CARs). This cutting-edge treatment gives cancer patients fresh hope while revolutionizing the field of oncology and raising survival rates.



Shanghai Changzheng Hospital

A prominent medical centre in Shanghai, China called Shanghai Changzheng Hospital has actively contributed to the development of CAR T-cell therapy. The creation and use of this ground-breaking cancer treatment have benefited greatly from their committed team of specialists and cutting-edge facilities. Changzheng Hospital has achieved outstanding results in the treatment of haematological malignancies, including leukaemia and lymphoma, by genetically altering patient T cells to express CARs. They are at the forefront of CAR T-cell treatment in China thanks to their dedication to research, clinical studies, and patient care. Shanghai Changzheng Hospital is making progress in this ground-breaking area and giving cancer patients and their families new hope.


Lu Daopei hospital beijing china

Lu-Daopei Hospital

Beijing, China’s Lu Daopei Hospital has significantly advanced the field of CAR T-cell treatment. Lu Daopei Hospital, which places a high priority on cancer treatment and research, has been at the forefront of applying CAR T-cell therapy to treat haematological malignancies. Oncologists, immunologists, and geneticists on their team have been committed to completing clinical trials and creating patient-specific CAR T-cell therapy. Lu Daopei Hospital has seen encouraging improvements in patient outcomes and survival rates because to their knowledge and cutting-edge facilities. Their work continues to influence how cancer is treated, opening up fresh opportunities for patients who are in need of hope. Till date they claim to have done more than 1000 CAR T-Cell therapy infusions.

First Affiliated Hospital of Zhengzhou University - Zhengzhou

First Affiliated Hospital of Zhengzhou University


In the field of CAR T-cell treatment, the First Affiliated Hospital of Zhengzhou University, situated in Zhengzhou, China, has become a well-known organisation. The hospital has made tremendous progress in maximising the potential of CAR T-cell therapy for patients by placing a major emphasis on cutting-edge cancer treatments. Oncologists, immunologists, geneticists, and other members of their interdisciplinary medical staff have all taken an active part in studies and clinical trials. The facility has treated haematological malignancies with impressive success thanks to the use of CAR T-cell therapy. As personalised cancer therapy develops, The First Affiliated Hospital of Zhengzhou University is in the forefront, giving patients fresh hope and a better quality of life.


Top doctor’s for CAR T-Cell therapy in China

Take expert second opinion on CAR T-Cell therapy infusion from best researchers in China. 

Peihua Peggy Lu Hematologist Lu Daopei Hospital Beijing China

Dr. Peihua (Peggy) Lu (MD)


Profile: Clinical professor and medical executive president of Lu Daopei hospital in China. She has had many awards which including National Cancer Institute individual fellowship award, physician scientist award (K011) from National Cancer institute.

Dr. Zhang Longji (MD, PhD)

Cell therapy & Immunology

Profile: Dr. Zhang was professor at the University of Florida School of Medicine, used to be a senior professor of immunology at the Moffitt Cancer Center in Florida, the United Nations Nuclear Energy Commission (IAEA) AIDS cancer research expert consultant, and the US Food and Drug Administration (FDA) gene cell therapy expert consultant.


Dr. Ye Zhenlong (MD, PhD)

Immune Cell therapy

Profile: Engaged in tumor immune cell therapy research and development and inspection and testing for 8 years, participated in the publication of 15 SCI papers in internationally renowned journals, participated in the compilation of 1 Chinese and English books; applied for 9 national invention patents. 


What is the cost of CAR T-Cell therapy in China?

Cost of CAR T-Cell therapy in China starts from $ 45,000 USD and can reach up to $ 80,000 USD depending upon the type and extent of disease and its burden on the body. It is crucial to keep in mind that this estimate is only a general approximation and that specific circumstances may change. The precise type of CAR-T therapy, the intricacy of the procedure, hospital costs, supportive care, and additional diagnostic testing are all variables that can affect price. To control the costs related to CAR-T cell therapy, it is advised for patients to speak with healthcare professionals and look into insurance coverage or financial help programmes.

What is CAR T-Cell therapy?

CAR-T-Cell- therapy in China

Chimeric antigen receptor T-cell therapy, often known as CAR T-cell therapy, is a ground-breaking immunotherapy that has completely changed the way that cancer is treated. It gives patients with certain cancers hope that were previously seen as incurable or with few therapeutic alternatives.

The treatment entails using a patient’s own immune cells—more specifically, T cells—and lab-modifying them to improve their capacity to detect and destroy cancer cells. To do this, the T cells are given a chimeric antigen receptor (CAR), which gives them the ability to target particular proteins, or antigens, on the surface of cancer cells.

T cells from the patient are first removed, and they are then genetically modified to express the CAR. In the laboratory, these altered cells are multiplied to produce a sizable population of CAR T cells, which are then put back into the patient’s bloodstream.

How it works CAR T Cell therapy in China

As soon as they are inside the body, CAR T cells find cancer cells that express the desired antigen, attach to them, and trigger a potent immune response. The CAR T cells that have been activated proliferate and conduct a focused attack on the cancer cells, killing them.


How does CAR T-Cell therapy work?

How CAR T Cell therapy works in Singapore

When used to treat some blood malignancies like acute lymphoblastic leukaemia (ALL) and specific forms of lymphoma, CAR T-cell therapy has shown exceptional results. It has produced notable response rates and in some patients, even long-lasting remissions.

CAR T-cell therapy, however, is a sophisticated and unique therapeutic method that might have risks and adverse effects. Cytokine release syndrome (CRS), a widespread immunological reaction that can result in flu-like symptoms and, in extreme situations, organ failure, may be experienced by certain people. There have also been reports of neurological adverse effects, however they are frequently curable.

Despite these difficulties, CAR T-cell therapy is a significant advancement in the fight against cancer and shows great potential for the future. Current studies are focused on enhancing its efficacy and safety profile as well as extending its uses to different cancer types. CAR T-cell therapy has the ability to change the face of cancer treatment and give patients everywhere new hope with further advancements.

This type of therapy involves modifying the patient’s T cells, an immune cell type, in the lab so they will bind to and kill cancer cells. A tube transports blood from a vein in the patient’s arm to an apheresis device (not shown), which extracts white blood cells, including T cells, and returns the remaining blood to the patient.
The T cells are then genetically modified in the lab to contain the gene for a unique receptor known as a chimeric antigen receptor (CAR). The CAR T cells are multiplied in a lab before being infused into the patient in large numbers. The antigen on the cancer cells can be recognized by CAR T cells, which then kill the cancer cells.


The CAR-T therapy procedure, which takes a few weeks, involves multiple steps:

T cells are extracted from your blood using a tube that is placed into an arm vein. This takes a couple of hours.

T cells are transported to a facility where they undergo genetic modification to become CAR-T cells. Two to three weeks pass throughout this.

CAR-T cells are reintroduced into your bloodstream through a drip. This requires several hours.

CAR-T cells target and eliminate cancer cells throughout the body. After receiving CAR-T therapy, you will be closely watched.

What type of cancer cells can be treated with CAR-T Cell Therapy? 

Only patients with adult B-cell non-lymphoma Hodgkin’s or pediatric acute lymphoblastic leukemia who have already tried two unsuccessful conventional therapies can currently use CAR T-cell therapy products that have received FDA approval. However, CAR T-cell therapy is now being tested in clinical studies as a first or second-line treatment for adult lymphoma and pediatric acute lymphoblastic leukemia. Recently, some of the studies have shown remarkable successes in cases of solid tumors too like glioblastoma, gliomas, liver cancer, lung cancer, GI cancer, pancreatic cancer and oral cancers.

To conclude

This represents a significant advancement in the management of leukemia and B-cell lymphoma. Additionally, it gives hope to those whose lives had previously been predicted to last only six months. Now that we have identified mechanisms of resistance and created more techniques to combat them, the future appears to be much more promising.

Get in touch with our highly experienced healthcare providers here at CancerFax for a free consultation to work out a suitable care plan for your healthcare needs. Please send your medical reports to or WhatsApp to +1 213 789 56 55.

What are the advantages of CAR-T Cell Therapy?

The main benefit is that CAR T-cell therapy only requires a single infusion and often only requires two weeks of inpatient care. Patients with non-Hodgkin lymphoma and pediatric leukemia who have just been diagnosed, on the other hand, typically need chemotherapy for at least six months or more.

The advantages of CAR T-cell therapy, which is actually a living medication, can persist for many years. If and when a relapse occurs, the cells will still be able to identify and target cancer cells because they can survive in the body for an extended period of time. 

Although the information is still developing, 42% of adult lymphoma patients who underwent CD19 CAR T-cell treatment were still in remission after 15 months. And after six months, two-thirds of patients with pediatric acute lymphoblastic leukemia were still in remission. Unfortunately, these patients had exceedingly aggressive tumors that weren’t successfully treated using traditional standards of care.

What type of patients would be good recipients of the CAR-T Cell Therapy?

Patients between the age of 3 Years to 70 Years have been tried with CAR T-Cell therapy for different type of blood cancers and has been found to be very effective. Many centers have claimed success rates of more than 80%. The optimum candidate for CAR T-cell therapy at this time is a juvenile with acute lymphoblastic leukemia or an adult with severe B-cell lymphoma who has already had two lines of ineffective therapy. 

Before the end of 2017, there was no accepted standard of care for patients who had already gone through two lines of therapy without experiencing remission. The only FDA-approved treatment that has so far proven to be significantly beneficial for these patients is CAR T-cell therapy.

How effective is CAR-T Cell therapy?

CAR T-cell therapy has been very effective in treating some types of blood cancer, like acute lymphoblastic leukaemia (ALL) and non-Hodgkin lymphoma. In clinical trials, the response rates have been very good, and a lot of patients have gone into full remission. In some cases, people who had tried every other medicine had long-lasting remissions or even possible cures.

One of the best things about CAR T-cell treatment is that it targets the right cells. The CAR receptors that have been added to the T cells can find specific marks on cancer cells. This makes it possible to give targeted treatment. This targeted method hurts healthy cells as little as possible and lowers the risk of side effects that come with traditional treatments like chemotherapy.

But it’s important to keep in mind that CAR T-cell therapy is still a new area that is still changing. Researchers and doctors are working hard to solve problems like the high cost, the possibility of serious side effects, and the fact that it only works for some types of cancer.

In the end, CAR T-cell therapy has shown to be a very successful way to treat some types of blood cancer. Even though it is a promising and powerful method, more study and clinical trials are needed to improve it and find new ways to use it. CAR T-cell therapy could change how cancer is treated and make things better for people all over the world if it keeps getting better.

Inclusion & exclusion criteria

Inclusion criteria for CAR T-cell therapy:

1. Patients with CD19+ B-cell Lymphoma(At least 2 prior combination chemotherapy regimens)

2. To be aged 3 to 75 years

3. ECOG score ≤2

4. Women of childbearing potential must have a urine pregnancy test taken and proven negative prior to the treatment. All patients agree to use reliable methods of contraception during the trial period and until follow-up for the last time.

Exclusion criteria for CAR T-cell therapy:

1. Intracranial hypertension or unconsciousness

2. Respiratory failure

3. Disseminated intravascular coagulation

4. Hematosepsis or Uncontrolled active infection

5. Uncontrolled diabetes.

CAR T-Cell therapies approved by USFDA

B-cell precursor acute lymphoblastic leukemia, relapsed or refractory diffuse large B-cell lymphoma

Complete response rate (CR): >90%

Target: CD19

Price: $475,000

Approval time: August 30, 2017

Relapsed or refractory diffuse large B-cell lymphoma, relapsed or refractory follicular cell lymphoma

Non-Hodgkin’s lymphoma Complete response rate (CR): 51%

Target: CD19

Price: $373,000

Approval time: 2017 October 18

Relapsed or refractory diffuse large B-cell lymphoma

Mantle cell lymphoma Complete response rate (CR): 67%

Target: CD19

Price: $373,000

Approved time: October 18, 2017

Relapsed or refractory diffuse large B-cell lymphoma

Complete response rate (CR): 54%

Target: CD19
Price: $410,300

Approved time: October 18, 2017

Relapsed or Refractory Multiple Myeloma 

Complete response rate: 28%

Target: CD19
Price: $419,500
Approved: October 18, 2017

What are the side effects of CAR-T Cell therapy?

Below mentioned are some of the side-effects of CAR T-Cell therapy.

  1. Cytokine release syndrome (CRS): The most prevalent and possibly significant side effect of CAR T-cell treatment is cytokine release syndrome (CRS). The flu-like symptoms, including fever, exhaustion, headaches, and muscle pain, are brought on by the modified T cells’ production of cytokines. In extreme circumstances, CRS may result in a high temperature, hypotension, organ failure, and even potentially fatal consequences. 
  2. Neurological Toxicity: Some patients may develop neurological side effects, which can range in severity from less serious signs like mild confusion and disorientation to more serious ones like seizures, delirium, and encephalopathy. After CAR T-cell infusion, neurological toxicity frequently happens during the first week. 
  3. Cytopenias: CAR T-cell treatment can result in low blood cell counts, such as anaemia (low red blood cell count), neutropenia (low white blood cell count), and thrombocytopenia (low platelet count). Infections, bleeding, and exhaustion are among risks that can be exacerbated by these cytopenias. 
  4. Infections: The CAR T-cell therapy’s suppression of healthy immune cells increases the risk of bacterial, viral, and fungal infections. In order to prevent infections, patients may need to be closely watched and given preventive medication.
  5. Tumour Lysis Syndrome (TLS): After CAR T-cell therapy, it’s possible in some circumstances for substantial amounts of cell contents to be released into the bloodstream due to the rapid killing of tumour cells. This may result in metabolic abnormalities, such as excessive potassium, uric acid, and phosphate levels, which may damage the kidneys and cause other problems. 
  6. Hypogammaglobulinemia: CAR T-cell treatment has the potential to decrease antibody synthesis, which could result in hypogammaglobulinemia. This might make recurrent infections more likely and call for continuing antibody replacement medication. 
  7. Organ Toxicity: CAR T-cell therapy has the potential to harm a number of organs, including the heart, lungs, liver, and kidneys. This may lead to abnormal renal function tests, respiratory issues, heart issues, and abnormal liver function tests.
  8. Hemophagocytic lymphohistiocytosis (HLH): A rare but possibly fatal immunological disease called hemophagocytic lymphohistiocytosis (HLH) can develop as a result of CAR T-cell therapy. It involves the overactivation of immune cells, which causes serious organ damage and inflammation.
  9. Hypotension and Fluid Retention: As a result of the cytokines that CAR T cells release, some patients may develop low blood pressure (hypotension) and fluid retention. To address these symptoms, supportive measures including intravenous fluids and drugs could be required.
  10. Secondary Malignancies: Reports of secondary malignancies emerging following CAR T-cell therapy exist, notwithstanding their rarity. Research is currently being done on the potential for secondary malignancies and long-term hazards.

It’s important to remember that not every patient will have these side effects, and that each person’s level of sensitivity will differ. In order to minimize and minimize these potential adverse effects, the medical team closely examines patients before, during, and after CAR T-cell therapy.

Time frame

Check below the total time frame required for complete the CAR T-Cell therapy process. Although time frame depends a lot on the distance of lab from the hospital that prepared the CAR’s.

  1. Examination & test: one week
  2. Pre-treatment & T-Cell Collection: one week
  3. T-Cell preparation & return: two-three weeks
  4. 1st Effectiveness analysis: three weeks
  5. 2nd Effectiveness analysis: three weeks.

Total time frame: 10-12 Weeks

Video on CAR T-Cell therapy in China?

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