June 2022: MALAYSIAN Genomics Resource Centre Bhd (MGRC) hopes to make its chimeric antigen receptor (CAR) T-Cell therapy treatment available in Malaysia for under RM200,000 i.e around $ 45000 USD, which is a fraction of the cost of therapy in Europe and the United States. Hope the CAR T-Cell therapy in Malaysia will bring cheers to thousands of patients who are hoping to get this breakthrough treatment.
Image: CAR T Cell therapy is been developed for some types of solid tumors too
According to Malaysian Genomics CEO Sasha Nordin, the company has teamed with China’s ICARTAB Biomedical Co Ltd, which is developing the technology exclusively for solid malignancies, despite the fact that similar treatments for liquid or blood diseases are already available in Western countries.
“Improving access to innovative items is part of our mandate.” We were able to reach an agreement that allows us to make it available to patients in Southeast Asia for a fraction of the price.
In an interview with The Malaysian Reserve yesterday, he said, “We are working on making it available for less than RM200,000 versus US$400,000 (RM1.61 million) at minimum in Europe and the US.”
MGRC will be the official distributor of CAR T-Cell treatment in Singapore, Brunei, Indonesia, Thailand, Vietnam, Cambodia, and Laos, in addition to Malaysia.
According to Sasha Omar, the company presently has medicines for six of the region’s top ten malignancies, including liver, pancreatic, mesothelioma, oesophagus, brain, and stomach tumours. He claims that CAR T-cell immunotherapy for solid cancer is not a mass-produced therapeutic.
Every treatment in the therapy is unique to the patient since it includes extracting the patient’s cells and allowing the patient’s T-cell, an important white blood cell in the immune system, to recognise the tumour.
The T-cell will then be reinfused into the patient’s body to detect and fight the malignant cell, preventing it from spreading further.
“Every time we meet a patient, we have to go through a qualification process to evaluate if they are a good candidate for CAR T-Cell therapy.” If they meet all of the criteria, we will produce T-cells exclusively for that patient.
“That is why we believe it is critical to make it considerably more affordable.” We can control the pricing a little better by fitting our own lab,” he said.
Sasha Omar stated that the company’s new laboratory will be operational by the end of March this year, and that activities will resume as soon as possible to accommodate the demand for the therapy.
The new 12,000 sq ft area will be in Kota Damansara, with the laboratory taking up around 7,000 sq ft of the space and the office structure taking up the remaining space.
New advanced drugs, such as CAR-T (chimeric antigen receptor T-cell), are life-changing medications for people who have exhausted their possible treatment options. These cutting-edge treatments are provided in non-traditional ways, including long, complicated, and highly organized series of activities inside the healthcare provider’s facilities. Providers will benefit from these treatments in a variety of ways, from enhancing their reputation as cutting-edge organisations to providing high-profit-generating programmes. However, delivering these latest advanced treatments poses significant financial and operating challenges if not carefully assessed and prepared.
CAR T-Cell therapy is a form of immunotherapy that uses specially modified T-cells which are part of our immune system to fight cancer. A sample of patients T cells are collected from the blood, then it is modified to produce special structures called chimeric antigen receptors (CAR) on their surface. When these modified CAR cells are re infused in the patient, these new cells attack the specific antigen and kills the tumor cells.
CAR T-cell therapy takes help from body’s own immune system to attack and kill cancer cells. This is done by removing some specified cells from the blood of the patient, modifying them in the lab and re-injecting them into the patient. CAR T-cell therapy has produced very encouraging results in Non-Hodgkin lymphoma and thus approved by FDA.
At present FDA has approved CAR T-Cell therapy for some forms of aggressive and refractory Non-Hodgkin lymphoma, Myeloma and relapsed and refractory acute lymphoblastic leukemia. Patient need to send full medical reports to ascertain the use of CAR T-Cell therapy for his treatment.
1. Patients with CD19+ B-cell Lymphoma(At least 2 prior combination chemotherapy regimens)
2. To be aged 3 to 75 years
3. ECOG score ≤2
4. Women of childbearing potential must have a urine pregnancy test taken and proven negative prior to the treatment. All patients agree to use reliable methods of contraception during the trial period and until follow-up for the last time.
1. Intracranial hypertension or unconsciousness
2. Respiratory failure
3. Disseminated intravascular coagulation
4. Hematosepsis or Uncontrolled active infection
5. Uncontrolled diabetes
1. Examination & test: one week
2. Pre-treatment & T-Cell Collection: one week
3. T-Cell preparation & return: two-three weeks
4. 1st Effectiveness analysis: three weeks
5. 2nd Effectiveness analysis: three weeks
Cost of CAR T-Cell therapy in Malaysia will be approximately between $ 45000 – 50,000 USD. For details on eligibility criteria and cost estimate please send your medical reports to info@cancerfax.com with your name and age as subject.
Also read this : CAR T Cell therapy in India
The common side effects of CAR T-cell therapy include:
CAR T-cell therapy for the treatment of lymphoma and other blood cancers has shown promising outcomes. Since CAR T-cell treatment, many patients who had previously relapsed blood tumours had promising results and no evidence of cancer. It has also aided in the rehabilitation of patients who have previously failed to respond to most traditional cancer therapies.
However, longer-term studies for a larger patient population are needed to validate the efficacy of this treatment. Large-scale experiments would also aid in determining the likelihood of side effects and the right ways to deal with them.
How can I take treatment in Malaysia ?
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