CAR-T therapy is a novel form of cancer treatment using the immune system to eradicate cancer cells. Where other therapies have failed, it has occasionally been able to heal patients. This blog will highlight all that you need to know about this procedure. Read on to
find out more!
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The immune system protects the body from infection and cancer. It is made up of billions of cells that are classified into many categories.
Lymphocytes are a type of white blood cell that make up a significant part of the immune system. Lymphocytes are divided into three categories.
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Immune cells or antibodies can be made in the lab under strict circumstances and then given to cancer patients as a treatment. Several forms of immunotherapy have been licensed for use or are being studied in clinical studies to see how successful they are in treating specific cancers.
A type of treatment in which a patient’s T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. CAR T-cell therapy is used to treat certain blood cancers, and it is being studied in the treatment of other types of cancer. Also called chimeric antigen receptor T-cell therapy. (Source: https://www.cancer.gov/)
CAR T-cell therapy, or chimeric antigen receptor treatment, is a new type of immunotherapy that uses specially engineered T cells to more precisely target cancer cells. The immune system is made up of cells and organs that work together to keep the body safe from infection and cancer. T cells are one type of cell that hunts down and kills aberrant cells, including cancer cells. Because cancer cells can sometimes elude the immune system, it is necessary to retrain the immune system to recognise and fight cancer cells. CAR T-cell therapy is a novel way of training the immune system to fight cancer.
After a sample of a patient’s T cells is taken from the blood, the cells are re-engineered to have specific structures on their surface called chimeric antigen receptors (CARs). The receptors on these CAR T cells may aid the T cells in identifying and attacking cancer cells throughout the body when they are reinjected into the patient.
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CAR T-cell therapy is now licensed by the FDA as the standard of care for certain types of relapsed or refractory non-Hodgkin lymphoma, multiple myeloma, and pediatric relapsed acute lymphoblastic leukaemia (ALL), and is being tested in additional types of blood cancer.
CAR T-Cell therapy is a form of immunotherapy that uses specially modified T-cells which are part of our immune system to fight cancer. A sample of patients T cells are collected from the blood, then it is modified to produce special structures called chimeric antigen receptors (CAR) on their surface. When these modified CAR cells are re infused in the patient, these new cells attack the specific antigen and kills the tumor cells.
CAR T-cell therapy takes help from body’s own immune system to attack and kill cancer cells. This is done by removing some specified cells from the blood of the patient, modifying them in the lab and re-injecting them into the patient. CAR T-cell therapy has produced very encouraging results in Non-Hodgkin lymphoma and thus approved by FDA.
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At present FDA has approved CAR T-Cell therapy for some forms of aggressive and refractory Non-Hodgkin lymphoma and relapsed and refractory acute lymphoblastic leukemia. Patient need to send full medical reports to ascertain the use of CAR T-Cell therapy for his treatment.
1. Patients with CD19+ B-cell Lymphoma(At least 2 prior combination chemotherapy regimens)
2. To be aged 3 to 75 years
3. ECOG score ≤2
4. Women of childbearing potential must have a urine pregnancy test taken and proven negative prior to the treatment. All patients agree to use reliable methods of contraception during the trial period and until follow-up for the last time.
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1. Intracranial hypertension or unconsciousness
2. Respiratory failure
3. Disseminated intravascular coagulation
4. Hematosepsis or Uncontrolled active infection
5. Uncontrolled diabetes.
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1. Examination & test: one week
2. Pre-treatment & T-Cell Collection: one week
3. T-Cell preparation & return: two-three weeks
4. 1st Effectiveness analysis: three weeks
5. 2nd Effectiveness analysis: three weeks
The common side effects of CAR T-cell therapy include:
CAR T-cell therapy continues to be available to patients who are participating in a clinical trial for indications or cancers other than the FDA approved indications. Trial protocols vary. Depending on the clinical trial, care may be provided in either a hospital setting or an intensive outpatient treatment center with experience administering cellular immunotherapy. Patients may have to stay at the treatment facility and may need to plan to stay close by before, during or following treatment. Some trial protocols require patients to confirm the availability of a caregiver before they can enroll in the trial.
CAR T-cell therapy for the treatment of lymphoma and other blood cancers has shown promising outcomes. Since CAR T-cell treatment, many patients who had previously relapsed blood tumours had promising results and no evidence of cancer. It has also aided in the rehabilitation of patients who have previously failed to respond to most traditional cancer therapies.
However, longer-term studies for a larger patient population are needed to validate the efficacy of this treatment. Large-scale experiments would also aid in determining the likelihood of side effects and the right ways to deal with them.
China is a world leader of CAR-T cell therapy & BMT. Till now there are more than 300 CAR-T cell clinical trials in progress. China’s CAR-T treatment is the most budget one around the world. Because the CAR-T cell preparation is free now ! The patients only have to pay for the treatment & services. Total cost of treatment will be around $60,000 -$80,000.
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Patient can call +91 96 1588 1588 or email to firstname.lastname@example.org with patient details and medical reports and we shall arrange for second opinion, treatment plan and estimate of expenses.