Drug for thrombocytopenia

Share This Post

Dova Pharmaceuticals said that the US Food and Drug Administration (FDA) approved its subsidiary AkaRx’s new drug Doptelet (avatrombopag) tablets for treating low platelet counts (thrombocytopenia) in adults with chronic liver disease (CLD) who are going to have surgery for cancer or a tooth. It is worth mentioning that this is the third new drug approved by the FDA within a week and the first drug currently approved for this purpose.

Platelets are colorless cells produced in the bone marrow that help form blood clots in blood vessels and prevent bleeding. Cancer chemotherapy usually causes thrombocytopenia.

Doptelet (avatrombopag) is the second generation, once-daily oral thrombopoietin (TPO) receptor agonist. Doptelet can mimic the effect of TPO, it is the main regulator of normal platelet production. The drug has received priority review qualifications to treat thrombocytopenia in adults with CLD who will undergo surgery.

Doptelet’s safety and effectiveness were verified in two trials (ADAPT-1 and ADAPT-2). These studies included a total of 435 patients with chronic liver disease and severe thrombocytopenia, who will undergo surgery that usually requires platelet transfusions. These trials evaluated the effect of oral doptelet at two dose levels compared to placebo for 5 days of treatment. The results showed that compared with the placebo group, a higher percentage of patients in the two-dose level Doptelet group had increased platelet counts and did not need to receive platelet transfusion or any rescue treatment on the day of surgery and within 7 days after treatment. The most common side effects of Doptelet are fever, stomach (abdominal) pain, nausea, headache, fatigue, and swelling of hands and feet (edema).

“Patients with low platelet counts and chronic liver disease requiring surgery have an increased risk of bleeding,” said Dr. Richard Pazdur, director of the Center for Excellence in Oncology and the acting director of the Office of Hematology and Oncology Products at the FDA Center for Drug Evaluation and Research. Increase the platelet count. This drug may reduce or eliminate the need for platelet transfusion, (platelet transfusion) may increase the risk of infection and other adverse reactions.

Website |  + posts

Subscribe To Our Newsletter

Get updates and never miss a blog from Cancerfax

More To Explore

Gene Therapy for Gaucher’s Disease in China
AI & Technology

Gene Therapy for Gaucher’s Disease in China

Gene therapy for Gaucher’s disease in China offers a potential cure by correcting the faulty GBA gene. Using viral vectors or CRISPR, this treatment could eliminate lifelong enzyme therapy. Costs range from
300
,
000

300,000–400,000 USD, covering infusion and monitoring. China leads in clinical trials and advanced care. Contact us on WhatsApp +852 6428 1793 to explore treatment options and eligibility today!

Gene Therapy for Wilson's Disease in China
Biotech Innovations

Gene Therapy for Wilson’s Disease in China

Gene therapy for Wilson’s disease in China offers a groundbreaking cure by correcting the faulty ATP7B gene. With advanced viral vector and CRISPR-based treatments, patients can potentially avoid lifelong medications. The cost ranges from
250
,
000
–250,000–300,000 USD, covering therapy and follow-up care. China leads in clinical trials and affordable gene therapies. Contact us on WhatsApp +852 6428 1793 to explore treatment options and eligibility today!

Need help? Our team is ready to assist you.

We wish a speedy recovery of your dear and near one.

Start chat
We Are Online! Chat With Us!
Scan the code
Hello,

CancerFax is the most trusted online platform dedicated to connecting individuals facing advanced-stage cancer with groundbreaking cell therapies.

Send your medical reports and get a free analysis.

🌟 Join us in the fight against cancer! 🌟

Привет,

CancerFax — это самая надежная онлайн-платформа, призванная предоставить людям, столкнувшимся с раком на поздних стадиях, доступ к революционным клеточным методам лечения.

Отправьте свои медицинские заключения и получите бесплатный анализ.

🌟 Присоединяйтесь к нам в борьбе с раком! 🌟