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Isethulo sokwelashwa kwamaseli e-CAR T, ukusetshenziswa kanye nokuvunyelwa

I-CAR T-Cell Therapy

Izindlela zesimanje ze-immunotherapy, njengokwelashwa kwe-CAR T-cell, zishintshe ngokuphelele indlela umdlavuza welashwa ngayo. Kubandakanya ukushintsha ngokofuzo amaseli T esiguli ukuze aveze ama-CAR, noma ama-chimeric antigen receptors, akwazi ukubona amaseli omdlavuza kuphela.

Lawa maseli aphinde afakwe esigulini, futhi lawa maseli e-CAR T ashintshiwe angakhomba futhi aqede amangqamuzana omdlavuza. Ngamazinga aphezulu okuphendula kanye nokukhululwa okuhlala isikhathi eside, ukwelashwa kwe-CAR T-cell kubonise ukusebenza kahle okungavamile ekwelapheni izinhlobo ezithile zezifo ezibulalayo zegazi, njenge-leukemia, i-lymphoma, kanye i-myeloma eminingi. 

Kuyini ukwelashwa kwe-CAR T-Cell?

Ukwelashwa kwe-CAR-T-Cell eChina

I-Chimeric antigen receptor T-cell therapy, ngokuvamile eyaziwa ngokuthi Ukwelashwa kwe-CAR T-cell, i-immunotherapy ephula phansi eye yashintsha ngokuphelele indlela leyo umdlavuza uyalashwa. Inikeza iziguli ezinomdlavuza othile ithemba ebekade libhekwa njengengelapheki noma kunezinye izindlela zokwelapha ezimbalwa.

Ukwelashwa kubandakanya ukusebenzisa amangqamuzana omzimba esiguli, ikakhulukazi, ama-T cell, kanye nokuwashintsha ilebhu ukuze kuthuthukiswe amandla awo okuthola nokubhubhisa amaseli omdlavuza. Ukwenza lokhu, ama-T cell anikezwa i-chimeric antigen receptor (CAR), ewanikeza amandla okukhomba amaprotheni athile, noma ama-antigen, ebusweni bamaseli omdlavuza.

Ama-T cell esiguli aqale akhishwe, bese eshintshwa izakhi zofuzo ukuze aveze i-CAR. Elabhorethri, la mangqamuzana ashintshiwe ayaphindaphindeka ukuze akhiqize inani elikhulu lamaseli e-CAR T, abese ebuyiselwa egazini lesiguli.

 

Isebenza kanjani ukwelashwa kwamaseli e-CAR T eChina

 

Ngokushesha nje lapho engaphakathi emzimbeni, amaseli e-CAR T athola amangqamuzana omdlavuza aveza i-antigen oyifunayo, anamathisele kuwo, futhi aqalise ukusabela okunamandla kokuzivikela komzimba. Amaseli e-CAR T acushiwe ayanda futhi ahlasele amangqamuzana omdlavuza, awabulale.

 

Isebenza kanjani ukwelashwa kwe-CAR T-Cell?

Isebenza kanjani i-CAR T Cell therapy eSingapore

Lapho isetshenziselwa ukwelapha izifo ezithile zegazi njenge I-acute lymphoblastic leukemia (YONKE) kanye nezinhlobo ezithile ze i-lymphoma, Ukwelashwa kwe-CAR T-cell kubonise imiphumela engavamile. Ikhiqize izilinganiso zokusabela eziphawulekayo futhi, kwezinye iziguli, ngisho nokukhululwa okuhlala isikhathi eside.

I-CAR T-cell therapy, nokho, iyindlela yokwelapha eyinkimbinkimbi neyingqayizivele engase ibe nezingozi nemiphumela emibi. I-Cytokine release syndrome (CRS), ukusabela okusakazekile kwe-immunology okungase kubangele izimpawu ezifana nomkhuhlane futhi, ezimweni ezimbi kakhulu, ukwehluleka kwezitho zomzimba, kungase kutholwe abantu abathile. Kubuye kube nemibiko yemiphumela emibi yezinzwa; nokho, ziyelapheka njalo.

Naphezu kwalobu bunzima, ukwelashwa kwe-CAR T-cell kuyintuthuko ebalulekile ekulweni nomdlavuza futhi kukhombisa amandla amakhulu ekusasa. Ucwaningo lwamanje lugxile ekuthuthukiseni ukusebenza kahle kwayo kanye nephrofayili yokuphepha kanye nokwelula ukusetshenziswa kwayo ezindaweni ezahlukene. izinhlobo zomdlavuza. I-CAR T-cell therapy inamandla okushintsha ubuso bokwelashwa komdlavuza futhi inikeze iziguli yonke indawo ithemba elisha ngentuthuko eyengeziwe.

Lolu hlobo lokwelapha lubandakanya ukulungisa ama-T cell esiguli, uhlobo lwamangqamuzana omzimba omzimba, elebhu ukuze abophe futhi abulale amangqamuzana omdlavuza. Ishubhu lithutha igazi lisuka emthanjeni osengalweni yesiguli liye emshinini obizwa ngokuthi i-apheresis (ongabonisiwe), okhipha amangqamuzana amhlophe egazi, kuhlanganise nama-T cell, bese ubuyisela igazi elisele esigulini.
 
Amaseli e-T abe eseshintshwa ngofuzo elebhu ukuze aqukathe ufuzo lwesamukeli esiyingqayizivele eyaziwa ngokuthi i-chimeric antigen receptor (CAR). Amaseli e-CAR T aphindaphindeka elebhu ngaphambi kokuthi afakwe esigulini ngamanani amakhulu. I-antigen emangqamuzaneni omdlavuza ingabonwa ngamaseli e-CAR T, abese ebulala amangqamuzana omdlavuza.
 

Inqubo

Inqubo yokwelapha i-CAR-T, ethatha amasonto ambalwa, ibandakanya izinyathelo eziningi:

Ama-T cell akhishwa egazini lakho kusetshenziswa ishubhu elifakwa emthanjeni wengalo. Lokhu kuthatha amahora ambalwa.

Ama-T cell athuthelwa endaweni, lapho enza khona ukuguqulwa kofuzo ukuze abe amaseli e-CAR-T. Amasonto amabili kuya kwamathathu adlula kulokhu.

Amangqamuzana e-CAR-T abuyiselwa egazini lakho nge-drip. Lokhu kudinga amahora ambalwa.

Amaseli e-CAR-T aqondisa futhi aqede amangqamuzana omdlavuza kuwo wonke umzimba. Ngemva kokuthola ukwelashwa kwe-CAR-T, uzobhekwa eduze.

Hlobo luni lwamaseli omdlavuza olungelashwa nge-CAR-T Cell Therapy? 

Iziguli ezinabantu abadala kuphela I-B-cell non-lymphoma Hodgkin's noma i-acute lymphoblastic leukemia yezingane asebezame izindlela zokwelapha ezimbili ezingaphumelelanga okwamanje bangasebenzisa imikhiqizo yokwelapha ye-CAR T-cell ethole imvume ye-FDA. Kodwa-ke, ukwelashwa kwe-CAR T-cell manje kuyahlolwa ezifundweni zomtholampilo njengokwelashwa komugqa wokuqala noma wesibili we-lymphoma yabantu abadala kanye ne-acute lymphoblastic leukemia yezingane. Muva nje, ezinye zezifundo zibonise impumelelo emangalisayo ezimeni eziqinile izicubu kakhulu i-glioblastoma, ama-gliomas, umdlavuza wesibindi, umdlavuza wamaphaphu, umdlavuza we-GI, umdlavuza we-pancreatic kanye nomdlavuza womlomo.

Ukuphetha

Lokhu kubonisa intuthuko enkulu ekulawuleni i-leukemia kanye ne-B-cell lymphoma. Ukwengeza, kunikeza ithemba kulabo okwabikezelwa ukuthi ukuphila kwabo kuzohlala izinyanga eziyisithupha kuphela. Manje njengoba sesihlonze izindlela zokumelana futhi sakha amasu amaningi okulwa nazo, ikusasa libonakala lithembisa kakhulu.

Thintana nabahlinzeki bethu bezempilo abanolwazi olunzulu lapha ku ICancerFax ukuze uthole ukubonisana kwamahhala ukuze wenze uhlelo lokunakekelwa olufanele lwezidingo zakho zezempilo. Sicela uthumele imibiko yakho yezokwelashwa ku-info@cancerfax.com noma ku-WhatsApp + 1 213 789 56 55.

Ukwelashwa komdlavuza e-United States of America

Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell eNdiya

Yiziphi izinzuzo ze-CAR-T Cell Therapy?

Inzuzo eyinhloko ukuthi ukwelashwa kwe-CAR T-cell kudinga kuphela ukumnika okukodwa futhi ngokuvamile kudinga kuphela amasonto amabili okunakekelwa kwesiguli. Iziguli nge i-non-Hodgkin lymphoma kanye ne-leukemia yezingane ezisanda kutholwa, ngakolunye uhlangothi, ngokuvamile zidinga ukwelashwa ngamakhemikhali okungenani izinyanga eziyisithupha noma ngaphezulu.

Izinzuzo zokwelashwa kwe-CAR T-cell, empeleni okuwumuthi ophilayo, zingaphikelela iminyaka eminingi. Uma futhi kwenzeka ukuphindeka, amaseli asazokwazi ukukhomba futhi aqondise amaseli omdlavuza ngoba angaphila emzimbeni isikhathi eside. 

Nakuba ulwazi lusathuthuka, u-42% weziguli ze-lymphoma zabantu abadala ezathola ukwelashwa kwe-CD19 CAR T-cell zazisenoshwele ngemva kwezinyanga eziyi-15. Futhi ngemva kwezinyanga eziyisithupha, izingxenye ezimbili kwezintathu zeziguli ezine-acute lymphoblastic leukemia zazisaxole. Ngeshwa, lezi ziguli zinezimila ezinolaka kakhulu ezingazange zilashwe ngempumelelo kusetshenziswa izindinganiso zendabuko zokunakekela.

Hlobo luni lweziguli ezingaba ngabamukeli abahle be-CAR-T Cell Therapy?

Iziguli ezineminyaka ephakathi kwemi-3 kuya kwengama-70 zizanywe nge-CAR T-Cell therapy ezinhlobonhlobo ze umdlavuza wegazi futhi kutholakale ukuthi iyasebenza kakhulu. Izikhungo eziningi ziye zafuna amanani empumelelo angaphezu kuka-80%. Umuntu ongcono kakhulu wokwelashwa kwe-CAR T-cell ngalesi sikhathi yingane ene-acute lymphoblastic leukemia noma umuntu omdala one-B-cell lymphoma enamandla osevele enemigqa emibili yokwelapha okungasebenzi. 

Ngaphambi kokuphela kuka-2017, lalingekho izinga elamukelekayo lokunakekela ezigulini esezidlule emigqeni emibili yokwelashwa ngaphandle kokuthola ukuxolelwa. Okuwukuphela kwendlela yokwelapha egunyazwe i-FDA kuze kube manje osekufakazele ukuthi kunenzuzo enkulu kulezi ziguli ukwelapha nge-CAR T-cell.

Kusebenza kahle kangakanani ukwelashwa kwamaseli e-CAR-T?

Ukwelashwa kwe-CAR T-cell kube yimpumelelo kakhulu ekwelapheni ezinye izinhlobo zomdlavuza wegazi, njenge-acute lymphoblastic leukemia (ALL) kanye ne-non-Hodgkin lymphoma. Ezivivinyweni zemitholampilo, amazinga okuphendula abe mahle kakhulu, futhi iziguli eziningi ziye zangena ekwelashweni okuphelele. Kwezinye izimo, abantu ababezame yonke eminye imithi baba nokukhululwa okuhlala isikhathi eside noma ngisho nokwelashwa okungenzeka.

Enye yezinto ezinhle kakhulu ngokwelashwa kwe-CAR T-cell ukuthi iqondise kumaseli afanele. Ama-receptor e-CAR angezwe kuma-T cell angathola amamaki athile kumaseli omdlavuza. Lokhu kwenza kube nokwenzeka ukunikeza ukwelashwa okuhlosiwe. Le ndlela ehlosiwe ilimaza amaseli anempilo kancane ngangokunokwenzeka futhi yehlisa ubungozi bemiphumela engemihle eza nokwelashwa kwendabuko okufana nokwelapha ngamakhemikhali.

Kodwa kubalulekile ukukhumbula ukuthi ukwelashwa kwe-CAR T-cell kuseyindawo entsha esashintsha. Abacwaningi nodokotela basebenza kanzima ukuxazulula izinkinga ezifana nezindleko eziphezulu, amathuba okuba nemiphumela emibi kakhulu, kanye neqiniso lokuthi kusebenza kuphela ezinhlotsheni ezithile zomdlavuza.

Ekugcineni, ukwelashwa kwe-CAR T-cell kubonise ukuthi kuyindlela ephumelela kakhulu yokwelapha ezinye izinhlobo zomdlavuza wegazi. Noma kuyindlela ethembisayo nenamandla, ucwaningo olwengeziwe nezivivinyo zomtholampilo ziyadingeka ukuze kuthuthukiswe futhi kutholwe izindlela ezintsha zokuyisebenzisa. Ukwelashwa kwe-CAR T-cell kungashintsha indlela umdlavuza welashwa ngayo futhi kwenze izinto zibe ngcono kubantu emhlabeni wonke uma uqhubeka nokuba ngcono.

Ukwelashwa komdlavuza e-United States of America

Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell kwa-Israyeli

Imibandela yokufakwa nokukhipha

Indlela yokufakwa yokwelashwa kwe-CAR T-cell:

1. Iziguli ezine-CD19 + B-cell Lymphoma (Okungenani ukuhlanganiswa kwangaphambili okungu-2 imiphumela emibi yokwelashwa ngamakhemikhali izinhlobo)

2.Ukuba neminyaka eyi-3 kuye kwengama-75

3. Isilinganiso se-ECOG ≤2

4. Abesifazane abanamandla okuthola izingane kumele babe nomchamo ukukhulelwa ukuhlolwa okwenziwe kwatholakala ukuthi une-negative ngaphambi kokwelashwa. Zonke iziguli ziyavuma ukusebenzisa izindlela ezithembekile zokuvimbela inzalo ngesikhathi sesilingo kuze kube kulandelwa okokugcina.

Imibandela yokungafakwa yokwelashwa kwe-CAR T-cell:

1.Ukuphakama komfutho wegazi ophakeme noma ukuquleka

2. Ukwehluleka kokuphefumula

3. Kusatshalaliswe i-coagulation ye-intravascular

4. I-Hematosepsis noma ukutheleleka okusebenzayo okungalawulwa

5. Okungalawulwa isifo sikashukela

Izindlela zokwelapha ze-CAR T-Cell zigunyazwe yi-USFDA

I-B-cell precursor acute lymphoblastic leukemia, ebuyele emuva noma i-refractory isakaza i-B-cell lymphoma enkulu

Izinga lokuphendula eliphelele (CR): >90%

Ithagethi: CD19

Price: $ 475,000

Isikhathi sokugunyaza: Agasti 30, 2017

I-B-cell lymphoma enkulu ebuyele emuva noma ephikisayo, ebuyele emuva noma ephikisayo ye-follicular cell lymphoma.

Izinga lokuphendula eliphelele le-Non-Hodgkin's lymphoma (CR): 51%

Ithagethi: CD19

Price: $ 373,000

Isikhathi sokugunyazwa: 2017 Okthoba 18

I-B-cell lymphoma ebuyiselwe emuva noma ephikisayo

I-Mantle cell lymphoma Izinga lokuphendula eliphelele (CR): 67%

Ithagethi: CD19

Price: $ 373,000

Isikhathi esivunyelwe: Okthoba 18, 2017

I-B-cell lymphoma ebuyiselwe emuva noma ephikisayo

Izinga lokuphendula eliphelele (CR): 54%

Ithagethi: CD19
Price: $ 410,300

Isikhathi esivunyelwe: Okthoba 18, 2017

I-Myeloma Ephindaphindekayo noma Ephikisayo 

Izinga lokuphendula eliphelele: 28%

Ithagethi: CD19
Price: $ 419,500
Kuvunyelwe: Okthoba 18, 2017

Iyini imiphumela emibi yokwelashwa kwe-CAR-T Cell?

Okubalulwe ngezansi eminye yemiphumela emibi yokwelashwa kwe-CAR T-Cell.

  1. I-Cytokine release syndrome (CRS): Umthelela oseceleni ovame kakhulu futhi okungenzeka ubaluleke kakhulu wokwelashwa kwe-CAR T-cell i-cytokine release syndrome (CRS). Izimpawu ezinjengomkhuhlane, okuhlanganisa imfiva, ukukhathala, ikhanda elibuhlungu, nobuhlungu bemisipha, zibangelwa ukukhiqizwa kwama-T cell ashintshiwe ama-cytokines. Ezimweni ezimbi kakhulu, i-CRS ingase ibangele izinga lokushisa eliphezulu, i-hypotension, ukwehluleka kwezitho, ngisho nemiphumela engase ibulale. 
  2. Ubuthi Bezinzwa: Ezinye iziguli zingase zibe nemiphumela engemihle yemizwa, engase ihluke kakhulu kusukela kuzimpawu ezingathí sina njengokudideka okuncane kanye nokudideka kuye kwezibucayi kakhulu njengokuquleka, ukudangala, kanye ne-encephalopathy. Ngemuva kokujova i-CAR T-cell, ubuthi bezinzwa buvame ukwenzeka phakathi nesonto lokuqala. 
  3. I-Cytopenias: Ukwelashwa kwe-CAR T-cell kungabangela ukubala okuphansi kwamangqamuzana egazi, njenge-anemia (isibalo esiphansi samangqamuzana egazi abomvu), i-neutropenia (isibalo esiphansi samangqamuzana egazi amhlophe), kanye ne-thrombocytopenia (isibalo esiphansi seplatelet). Ukutheleleka, ukopha, nokukhathala kuphakathi kwezingozi ezingabhebhethekiswa yilezi cytopenias. 
  4. Amagciwane: Ukucindezela kwe-CAR T-cell therapy kwamangqamuzana omzimba anempilo kwandisa ingozi yokutheleleka ngamagciwane, igciwane, kanye nesikhunta. Ukuze kuvinjwe izifo, iziguli kungase kudingeke ukuthi zibhekwe ngeso elibukhali futhi zinikezwe imithi yokuzivikela.
  5. I-Tumor Lysis Syndrome (TLS): Ngemva kokwelashwa kwe-CAR T-cell, kwezinye izimo kuyenzeka ukuthi amanani amakhulu wokuqukethwe kweseli akhishelwe egazini ngenxa yokubulawa ngokushesha kwamaseli esimila. Lokhu kungase kubangele ukuphazamiseka kwezinqubo ze-metabolic, okufana namazinga e-potassium eningi, i-uric acid, ne-phosphate, okungase kulimaze izinso futhi kubangele nezinye izinkinga. 
  6. I-Hypogammaglobulinemia: Ukwelashwa kwe-CAR T-cell kunamandla okunciphisa ukwakheka kwe-antibody, okungase kubangele i-hypogammaglobulinemia. Lokhu kungase kwenze izifo eziphindelelayo zibe nokwenzeka kakhulu futhi kubize ukuqhubeka kwemithi yokubuyisela amasosha omzimba. 
  7. Ubuthi Bomzimba: I-CAR T-cell therapy inamandla okulimaza izitho eziningi, okuhlanganisa inhliziyo, amaphaphu, isibindi, nezinso. Lokhu kungase kuholele ekuhlolweni kokusebenza okungavamile kwezinso, izinkinga zokuphefumula, izinkinga zenhliziyo, nokuhlolwa kokusebenza okungavamile kwesibindi.
  8. I-Hemophagocytic lymphohistiocytosis (HLH): Isifo esingandile kodwa esibulalayo esibizwa ngokuthi i-hemophagocytic lymphohistiocytosis (HLH) singakhula ngenxa yokwelashwa kwe-CAR T-cell. Kuhilela ukusebenza ngokweqile kwamangqamuzana omzimba omzimba, okubangela ukulimala okukhulu kwezitho nokuvuvukala.
  9. I-Hypotension kanye nokugcinwa koketshezi: Njengomphumela wama-cytokines akhishwa amaseli e-CAR T, ezinye iziguli zingase zibe nomfutho wegazi ophansi (hypotension) nokugcinwa koketshezi. Ukubhekana nalezi zimpawu, kungase kudingeke izinyathelo ezisekelayo ezihlanganisa uketshezi olufakwa emthanjeni nezidakamizwa.
  10. Izifo Zesibili: Imibiko yezifo zesibili ezibulalayo ezivela ngemva kokwelashwa kwe-CAR T-cell ikhona, kungakhathaliseki ukuthi inqabile. Njengamanje ucwaningo luyenziwa mayelana namathuba ezifo zesibili kanye nezingozi zesikhathi eside.

Kubalulekile ukukhumbula ukuthi akusona sonke isiguli esizoba nale miphumela engemihle, nokuthi izinga lomuntu ngamunye lokuzwela lizohluka. Ukuze kuncishiswe futhi kuncishiswe le miphumela emibi engaba khona, ithimba lezokwelapha lihlolisisa iziguli ngaphambi, phakathi, nangemuva kokwelashwa kwe-CAR T-cell.

Ukwelashwa komdlavuza e-United States of America

Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell eChina

Ubude besikhathi

Bheka ngezansi kwengqikithi yesikhathi esidingekayo ukuze uqedele inqubo yokwelapha ye-CAR T-Cell. Nakuba isikhathi sincike kakhulu ebangeni lelebhu esuka esibhedlela elungise i-CAR.

  1. Ukuhlolwa nokuhlolwa: isonto elilodwa
  2. Ukwelashwa kwangaphambili & Ukuqoqwa kwe-T-Cell: isonto elilodwa
  3. Ukulungiswa kwe-T-Cell nokubuyisela: amasonto amabili-amathathu
  4. Ukuhlaziywa kwe-1st Ukusebenza kahle: amaviki amathathu
  5. Ukuhlaziywa kwe-2nd Ukusebenza kahle: amaviki amathathu.

Isikhathi esiphelele: 10-12 Amaviki

Izindleko Ukwelashwa kwe-CAR T-Cell

Ukwelashwa kwe-CAR T cell kuyindlela entsha nenamandla yokwelapha ezinye izinhlobo zomdlavuza, ikakhulukazi umdlavuza wegazi njenge-leukemia ne-lymphoma. Kodwa kuyaziwa nangokubiza. Izindleko zokwelashwa kwe-CAR T cell zincike ezintweni eziningi, njengohlobo lokwelapha olusetshenziswayo, uhlobo lomdlavuza olashwayo, nohlelo lokunakekelwa kwezempilo lwezwe.

Ngokuvamile, ukwelashwa kwe-CAR T cell kuyinqubo eyinkimbinkimbi ehilela ukuthatha amangqamuzana omzimba esiguli, ukuwashintsha elebhu ukuze aveze ama-chimeric antigen receptors (CARs), bese uwabuyisela esigulini ukuze aqondise futhi abulale amangqamuzana omdlavuza. . Kusukela ekuqoqeni amangqamuzana kuya ekuwabuyiseleni esigulini, yonke le nqubo idinga izikhungo ezikhethekile, ochwepheshe bezokwelapha abanekhono, nobuchwepheshe obusezingeni eliphezulu, konke okwenezela ezindlekweni. 

Ukwelashwa kwe-CAR T cell kungabiza noma kuphi ukusuka emashumini ezinkulungwane zamaRandi kuya ezigidini zamaRandi ukwelashwa ngakunye. Lokhu akubandakanyi kuphela izindleko zokwelashwa ngokwako, kodwa nezindleko zokuhlolwa kwangaphambi kokwelashwa, ukulaliswa esibhedlela, ukulandelela, kanye nokubhekana nanoma yimiphi imiphumela emibi engase ibe khona. Futhi, ezinye iziguli zingase zidinge ngaphezu komthamo owodwa wokwelashwa kwamaseli e-CAR T, okunganezela ezindlekweni eziphelele.

Ngisho noma izindleko eziphezulu zokwelashwa kwe-CAR T cell zenza kube nzima ukuthi iziguli nezinhlelo zokunakekelwa kwezempilo zikhokhele, kubalulekile ukukhumbula ukuthi ukucwaninga okuqhubekayo kanye nenqubekela phambili kulo mkhakha kusebenzela ukwenza lokhu kwelashwa kube lula ukukuthola futhi kungabizi kakhulu. Abantu basebenzela ukwenza lula inqubo yokukhiqiza, ukunciphisa izindleko, futhi babheke ezinye izindlela zokukhokha ukuze benze lokhu kwelashwa okuyisisekelo kufinyeleleke kakhudlwana futhi kunikeze abantu abaningi ukufinyelela kukho.

 

Izindleko zokwelashwa kwe-CAR T-Cell emazweni ahlukene:

 

I-USA - $ 500,000 - 700,000 USD

I-Israel - $ 75,000 - 100,000 USD

I-China - $ 60,000 - 80,000 USD

I-UK - $ 500,000 - 700,000 USD

I-Singapore - $ 500,000 - 700,000 USD

I-Australia - $ 500,000 - 700,000 USD

INingizimu-Korea - $ 500,000 - 700,000 USD

Japan - $ 500,000 - 700,000 USD

 

Ukwelashwa komdlavuza e-United States of America

Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell eNingizimu-Korea

Isiqophi: Ukwelashwa kwe-CAR T-Cell

U-Emily Whitehead – Isiguli sokuqala ukuthola ukwelashwa kwe-CAR T-Cell

 
Ukwelashwa komdlavuza kwesigaba sokugcina u-Emily
 
I-CAR T Ukwelashwa kwamaseli esigabeni sokugcina sokwelashwa komdlavuza
 

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Okwakamuva kumdlavuza

I-CAR T Cell Therapy Esekelwe Kubantu: Ukuphumelela Nezinselele

I-CAR T Cell Therapy Esekelwe Kubantu: Ukuphumelela kanye Nezinselele

Kwangathi 4, 2024 Awekho amazwana

Ukwelashwa kwe-CAR T-cell okusekelwe kumuntu kuguqula ukwelashwa komdlavuza ngokushintsha izakhi zofuzo amaseli omzimba esiguli ukuze aqondise futhi abhubhise amaseli omdlavuza. Ngokusebenzisa amandla esimiso somzimba sokuzivikela ezifweni, lezi zindlela zokwelapha zinikeza ukwelashwa okunamandla futhi okuqondene nomuntu okungahle kube nokuxolelwa okuhlala isikhathi eside ezinhlotsheni ezihlukahlukene zomdlavuza.

Funda kabanzi "
Ukuqonda I-Cytokine Release Syndrome: Izimbangela, Izimpawu, Nokwelashwa

Ukuqonda I-Cytokine Release Syndrome: Izimbangela, Izimpawu, Nokwelashwa

April 29, 2024 Awekho amazwana

I-Cytokine Release Syndrome (CRS) iwukusabela kwamasosha omzimba okuvame ukubangelwa izindlela zokwelapha ezithile ezifana ne-immunotherapy noma i-CAR-T cell therapy. Kuhilela ukukhululwa ngokweqile kwama-cytokines, okubangela izimpawu ezisukela kumkhuhlane nokukhathala kuya ezinkingeni ezingase zibeke ukuphila engozini njengokulimala kwesitho. Ukuphatha kudinga ukuqapha ngokucophelela kanye namasu okungenelela.

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Iqhaza labezimo eziphuthumayo empumelelweni yokwelashwa kwe-CAR T Cell

Iqhaza labezimo eziphuthumayo empumelelweni yokwelashwa kwe-CAR T Cell

April 29, 2024 Awekho amazwana

Abezimo eziphuthumayo badlala indima ebalulekile empumelelweni yokwelashwa kwe-CAR T-cell ngokuqinisekisa ukunakekelwa kwesiguli okungenamthungo kuyo yonke inqubo yokwelashwa. Banikeza ukwesekwa okubalulekile ngesikhathi sokuthutha, ukuqapha izimpawu ezibalulekile zeziguli, nokuphatha ukungenelela kwezokwelapha eziphuthumayo uma izinkinga ziphakama. Ukusabela kwabo okusheshayo kanye nokunakekelwa kochwepheshe kunomthelela ekuphepheni okuphelele nasekusebenzeni ngempumelelo kokwelashwa, kusiza uguquko olushelelayo phakathi kwezilungiselelo zokunakekelwa kwezempilo kanye nokwenza ngcono imiphumela yesiguli endaweni eyinselele yezindlela zokwelapha ezithuthukisiwe zamaselula.

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Indlela Ukwelapha Okuhlosiwe Kuyiguqula Kanjani Ukwelashwa Komdlavuza Okuthuthukile

Ngabe Ukwelashwa Okuhlosiwe Kuguqula Kangakanani Ukwelashwa Komdlavuza Okuthuthukile?

April 25, 2024 Awekho amazwana

Emkhakheni we-oncology, ukuvela kokwelashwa okuhlosiwe kuye kwaguqula isimo sokwelashwa komdlavuza oseqophelweni eliphezulu. Ngokungafani ne-chemotherapy evamile, eqondisa kabanzi amangqamuzana ahlukanisa ngokushesha, ukwelashwa okuhlosiwe kuhloswe ukuhlasela amangqamuzana omdlavuza ngokukhetha kuyilapho kunciphisa umonakalo kumaseli avamile. Le ndlela enembayo yenziwa yenzeke ngokuhlonza izinguquko ezithile zamangqamuzana noma ama-biomarker ahlukile kumaseli omdlavuza. Ngokuqonda amaphrofayili amangqamuzana ezimila, izazi ze-oncologists zingakwazi ukuhlanganisa izindlela zokwelapha ezisebenza kahle kakhulu futhi ezinobuthi obuncane. Kulesi sihloko, sihlolisisa izimiso, izinhlelo zokusebenza, kanye nentuthuko yokwelapha okuhlosiwe kumdlavuza othuthukile.

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Siku-inthanethi! Xoxa Nathi!
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ICancerFax iyinkundla yokuphayona ezinikele ekuxhumaniseni abantu ababhekene nomdlavuza oseqophelweni eliphezulu ngemithi yokwelapha yamangqamuzana efana ne-CAR T-Cell therapy, ukwelashwa kwe-TIL, nezivivinyo zomtholampilo emhlabeni wonke.

Sazise ukuthi yini esingakwenzela yona.

1) Ukwelashwa komdlavuza phesheya?
2) Ukwelashwa kwe-CAR T-Cell
3) Umuthi wokugomela umdlavuza
4) Ukubonisana ngevidiyo eku-inthanethi
5) Ukwelashwa kweProton