Febhuwari 2024: Ukwelashwa kwe-Tumor-infiltrating lymphocyte (TIL). Ukwelashwa kuyindlela engaba khona esebenzisa amasosha omzimba ukulwa nezimila eziqinile. Le ndawo yokwelapha e-China ithuthuka ngokushesha ngenxa yokukhula kwezimali kwezwe ekwelapheni amaseli kanye namabhizinisi okuhlela izakhi zofuzo, naphezu kokuba lincane kakhulu. Ukwelashwa kwe-TIL e-China kuhlangabezana nezinkinga ezifana nengqalasizinda enganele, ukungabibikho kwezivumelwano ezimisiwe, kanye nokuqonda okunganele kokukhethwa kweziguli nezinhlanganisela zokwelashwa okufanele. Ukuvela kwe-chimeric antigen receptor (CAR)-T ukwelashwa kwamaseli e-China ikhuthaze indawo ekahle yokuthuthukiswa kokwelashwa kwe-TIL, ikhuthaza ukubambisana phakathi kwezikhungo namafemu azimele.
Inqubekelaphambili kanye nokusetshenziswa
UDkt. Steven Rosenberg welaphe ngempumelelo izifo zamagundane ngama-TIL e-autologous ngasekupheleni kwawo-1980, lapho eqala ukuthuthuka. Ukwelashwa kwe-TIL. Kusukela lapho, ukwelashwa kwe-TIL kuthuthuke kakhulu, okubonisa ukusebenza kahle okukhulu kumathumba athile aqinile, ikakhulukazi i-melanoma, umdlavuza womlomo wesibeletho, nomdlavuza we-colorectal.
Ungahle uthande ukufunda: I-CAR T-Cell Therapy e-China
Izilingo Zomtholampilo kanye Nenqubekelaphambili
I-Grit Biotechnology, enekomkhulu e-Shanghai, ithole amaRandi ayizigidi ezingu-60 ku-Series B yoxhaso ukuze kuthuthukiswe abantu abazongenela ukhetho lwe-TIL, ngokugcizelela kakhulu kumdlavuza we-melanoma, womlomo wesibeletho, nowamaphaphu. Le mizamo ihambisana namaphethini omhlaba wonke ekwelapheni kwe-TIL, okuvame ukuhlanganisa ukwelapha okuyinhlanganisela namanye ama-immunotherapies, njengemithi evimba amasosha omzimba.
Ucwaningo lwakamuva lugcizelele ukuthi ukwakheka nendawo yama-TIL ngaphakathi kwamathumba yizici ezibalulekile ezithinta ukubikezela kanye nemiphumela yokwelashwa. Ukuqonda ubudlelwano obuyinkimbinkimbi phakathi kwama-TIL kanye ne-tumor microenvironment kubalulekile ukuze kuthuthukiswe ukwelashwa kwe-TIL okuklanyelwe izinhlobo ezithile zesimila kanye nokucwengwa kwezigaba zesiguli.
Amacebo Esikhathi Esizayo
Kunezici eziningana ezinkulu ezidinga ukunakwa ukuze kusetshenziswe ngokugcwele amandla we Ukwelashwa kwe-TIL e-China.
Ukumisa: Ukuma kuhlanganisa ukudala izivumelwano ezingaguquki zokuhlukaniswa kwe-TIL, ukukhula, nokulethwa ukuze kuvunyelwe ukuqhathanisa okulula phakathi kwezifundo zomtholampilo kanye nokuthuthukisa ukuqonda kwemiphumela yocwaningo.
Ukukhetha Kwesiguli: Ukwakha amaphaneli ama-biomarker aqinile ukuze ukhethe iziguli ezingazuza ekwelashweni kwe-TIL kubalulekile ekwabiweni kwezinsiza ezifanele kanye nokukhulisa ukusebenza kahle kokwelashwa.
Ukusebenzisana: Ukukhuthaza ukubambisana phakathi kwezikhungo zemfundo, izibhedlela, kanye nozakwethu bezimboni kuzothuthukisa ukuqanjwa kabusha futhi kusheshise ukuhunyushwa kokwelashwa okusha kwe-TIL ekwenzeni umtholampilo.
Imfundo: Ukunikeza izinhlelo zokuqeqesha ezenziwe ngokwezifiso kanye nezinsiza zemfundo zochwepheshe bezokunakekelwa kwezempilo abazibandakanya kuzo Ukwelashwa kwe-TIL izothuthukisa izinqubo ezingcono kakhulu futhi ikhulise ukuqwashisa ngentuthuko yamanje endaweni.
Ungahle uthande ukufunda: I-CAR T Cell therapy ye-myeloma eminingi e-China
Ukugxila okwengeziwe ocwaningweni nasemfundweni e-China kuzosekela ukuthuthukiswa kokwelashwa kwe-TIL kwamathumba aqinile ngokugqugquzela ukuqamba okusha nokudala izindlela zokwelapha eziphephile nezisebenzayo.
Siyini isimo samanje se-tumor infiltrating lymphocyte therapy e-China?
Ukwelashwa kwe-tumor-infiltrating lymphocyte (TIL) kusesezingeni eliphezulu e-China. Ngokusho kwamahemuhemu akamuva, i-US Food and Drug Administration ingase inikeze imvume yokuqasha ukwelashwa kwe-TIL ukwelapha eminye imidlavuza. Inesithembiso esihle sokwelapha imidlavuza eqinile. Ukusebenzisa amaseli e-chimeric antigen receptor (CAR)-T ekwelapheni kuye kwasheshisa ukukhula kokwelashwa kwe-TIL e-China, okwenza kube lula ngezinkampani ezisebenza ekwelapheni kwamaseli nokuhlela izakhi zofuzo ukwenza kahle.
Izici ezibalulekile zokwelashwa kwe-TIL e-China yilezi:
• Ingqalasizinda enomkhawulo kanye nemithethonqubo echaziwe
• Gxila kumdlavuza we-melanoma, womlomo wesibeletho, nowomdlavuza wesikhumba
• Ukusebenzisana nezinhlangano zamazwe ngamazwe kanye nezinkampani ezizimele
• Izinhlelo zemfundo zochwepheshe bezokwelapha
Nakuba ukwelashwa kwe-TIL kubonise impumelelo emangalisayo ezinhlotsheni ezithile zesimila, ukuqaliswa kwakho kuhlala kunzima ngenxa yezici ezifana nezivuno eziphansi ze-TIL, ukuphikelela okungekuhle kwe-TIL ngemva kokumnika, kanye nezinselele zokuthuthukisa izivumelwano ezingaguquki.
Amathuba wesikhathi esizayo wokwelashwa kwe-TIL e-China ahlanganisa:
• Amasu okuhlukaniswa kwe-TIL asezingeni, ukunwetshwa, kanye nokuphatha
• Ukukhethwa kwesiguli okuthuthukisiwe nezinhlanganisela zokwelapha
• Ukubambisana okuthuthukisiwe phakathi kwezifundiswa, izibhedlela, nozakwethu bemboni
• Izinsiza zemfundo ezandisiwe zabahlinzeki bezempilo
Lezi zinyathelo zihlose ukukhulisa ukusetshenziswa kokwelashwa kwe-TIL e-China, ekugcineni kuholele ekwelashweni kwesimila esiqinile esiphephile nesisebenzayo.
Yiziphi izinhlobo ezivame kakhulu zomdlavuza ezilashwa ngokwelashwa kwe-TIL?
Izinhlobo ezivame kakhulu zomdlavuza ezilashwa nge-tumor-infiltrating lymphocyte (TIL) therapy yilezi:
I-melanoma: Ukwelashwa kwe-TIL kuphumelela ekwelapheni i-melanoma, uhlobo lomdlavuza wesikhumba.
Umdlavuza womlomo wesibeletho: Ukwelashwa kwe-TIL kubonise imiphumela ethembisayo ezigulini ezinomdlavuza womlomo wesibeletho, okuholela ekunciphiseni kwesimila kanye nokwanda kwamazinga okusinda.
Umdlavuza we-colorectal: Ukwelashwa kwe-TIL kubonise impumelelo yokuqala ezigulini ezinomdlavuza we-colorectal, okuphakamisa ukuthi kungenzeka kube nalolu hlobo lomdlavuza.
Nakuba ukwelashwa kwe-TIL kusesezigabeni zakho zokuqala e-China, ucwaningo oluqhubekayo kanye nezifundo zomtholampilo ziphenya ukuthi zisebenza kanjani kumathumba amaningi aqinile, okubonisa ukuguquguquka kwawo kanye nesithembiso sokusetshenziswa kabanzi esikhathini esizayo.
Izindleko zokwelashwa kwe-TIL e-China
Ukwelashwa kwe-TIL kusezigabeni zokuvivinywa njengamanje, futhi sekukonke izindleko zokwelashwa kwe-TIL e-China zingaba phakathi kuka-$60,000 no-$125,000 USD. Izindleko zokwelashwa kwamaseli e-CAR T e-China iphakathi kuka-$45,000 no-$80,000 USD. Izindleko zokwelashwa kwe-TIL zingahluka kuye ngohlelo oluthile lokwelapha, isibhedlela, nezinye izici. Kunconywa ukuthi uthintane nomhlinzeki wezempilo noma isibhedlela e-China ukuze uthole ulwazi olwengeziwe ngezindleko zokwelashwa kwe-TIL.
