I-CAR T-Cell Therapy E-Malaysia

I-MALAYSIAN Genomics Resource Center Bhd (MGRC) uthemba ukwenza i-chimeric antigen receptor yayo (CAR) Ukwelashwa kwe-T-Cell Ukwelashwa okutholakala e-Malaysia ngaphansi kuka-RM200,000 okungukuthi cishe u-$45,000 USD, okuyingxenyana yezindleko zokwelapha e-Europe nase-United States. Ngethemba ukuthi ukwelashwa kwe-CAR T-Cell e-Malaysia kuzoletha injabulo ezinkulungwaneni zeziguli ezinethemba lokuthola lokhu kwelashwa okuphumelelayo.

Isithombe: I-CAR T Ukwelashwa kwamaseli kusungulwe ezinye izinhlobo zamathumba aqinile

Ngokusho kukaSasha Nordin oyisikhulu esiphezulu seMalaysian Genomics, le nkampani ibambisene nenkampani yaseChina i-ICARTAB Biomedical Co Ltd, ethuthukisa lobu buchwepheshe ukuze bathole izifo ezibulalayo eziqinile, naphezu kweqiniso lokuthi izindlela zokwelapha ezifanayo zezifo eziwuketshezi noma zegazi seziyatholakala emazweni aseNtshonalanga.

"Ukuthuthukisa ukufinyelela ezintweni ezintsha kuyingxenye yesibopho sethu." Sikwazile ukufinyelela esivumelwaneni esisivumela ukuthi siyenze itholakale ezigulini eziseNingizimu-mpumalanga ye-Asia ngengxenye yentengo.

Engxoxweni abe nayo ne-Malaysian Reserve izolo, uthe, “Sisebenzela ukuthi itholakale ngemali engaphansi kuka-R200,000 uma iqhathaniswa no-US$400,000 (RM1.61 million) okungenani e-Europe nase-US.”

I-MGRC izoba ngumsabalalisi osemthethweni wokwelashwa kwe-CAR T-Cell eSingapore, Brunei, Indonesia, Thailand, Vietnam, Cambodia, naseLaos, ngaphezu kweMalaysia.

Ngokuka-Sasha Omar, inkampani njengamanje inemithi yezifo eziyisithupha kweziyishumi eziphambili esifundeni, okuhlanganisa isibindi, i-pancreatic, i-mesothelioma, i-oesophagus, ubuchopho, nezimila zesisu. Uthi i-CAR T-cell immunotherapy yomdlavuza oqinile akuyona indlela yokwelapha ekhiqizwa ngobuningi.

Yonke imithi yokwelapha iyingqayizivele esigulini njengoba ihlanganisa ukukhipha amangqamuzana esiguli kanye nokuvumela i-T-cell yesiguli, ingqamuzana elimhlophe legazi elibalulekile esimisweni sokuzivikela ezifweni, ukuba libone isimila.

I-T-cell izobe isibuyiselwa emzimbeni wesiguli ukuze ibone futhi ilwe nengqamuzana eliyingozi, ivimbele ukuthi lingasakazeki ngokuqhubekayo.

“Ngaso sonke isikhathi uma sihlangana nesiguli, kufanele sidlule ohlelweni lweziqu ukuze sihlole ukuthi sikulungele yini ukuthola i-CAR T-Cell therapy.” Uma ehlangabezana nazo zonke izimfuneko, sizokhiqiza ama-T-cell aleso siguli kuphela.

"Kungakho sikholelwa ukuthi kubalulekile ukulenza lithengeke kakhulu." Singakwazi ukulawula amanani kangcono ngokufaka elebhu yethu,” kusho yena.

USasha Omar uthe ilabhorethri entsha yenkampani izosebenza ekupheleni kukaMashi kulo nyaka, nokuthi imisebenzi izophinda iqale ngokushesha ukuze kuhlangatshezwane nesidingo sokwelashwa.

Indawo entsha engu-12,000 sq ft izoba se-Kota Damansara, nelabhorethri ithatha indawo engaba ngu-7,000 sq ft kanye nesakhiwo sehhovisi sithatha indawo esele.

Izidakamizwa ezisanda kwakhiwa, njenge-CAR-T (chimeric antigen receptor T-cell), ziyimithi eshintsha impilo yabantu asebesebenzise izindlela zabo zokwelapha ezingase zibe khona. Lezi zindlela zokwelapha ezisezingeni eliphezulu zihlinzekwa ngezindlela okungezona ezendabuko, okuhlanganisa uchungechunge olude, oluyinkimbinkimbi, noluhlelwe kakhulu lwemisebenzi ngaphakathi kwezikhungo zomhlinzeki wezempilo. Abahlinzeki bazozuza kulokhu kwelashwa ngezindlela ezihlukahlukene, kusukela ekuthuthukiseni isithunzi sabo njengenhlangano esezingeni eliphezulu ukuya ekuhlinzekeni ngezinhlelo ezikhiqiza inzuzo ephezulu. Kodwa-ke, ukuletha lokhu kwelashwa kwakamuva okuthuthukile kubangela izinselele ezinkulu zezezimali nokusebenza uma kungahlolisiswa futhi kulungiselelwe ngokucophelela.

Kuyini ukwelashwa kwe-CAR T-Cell (Chimeric antigen receptors)?

Ukwelashwa kwe-CAR T-Cell kuwuhlobo lwe-immunotherapy olusebenzisa ama-T-cell aguqulwe ngokukhethekile ayingxenye yohlelo lwethu lokuzivikela ezifweni silwe nomdlavuza. Isampula yeziguli T amaseli aqoqwa egazini, bese eguqulwa ukuze akhiqize izakhiwo ezikhethekile ezibizwa nge-chimeric antigen receptors (CAR) ebusweni bazo. Lapho la maseli e-CAR ashintshiwe ebuyiselwa esigulini, lawa maseli amasha ahlasela i-antigen ethile futhi abulale amaseli wesimila.

Isebenza kanjani ukwelashwa kwe-CAR T-Cell?

Ukwelashwa kwe-CAR T-cell kuthatha usizo kumasosha omzimba uqobo ukuze kuhlasele futhi kubulale amangqamuzana omdlavuza. Lokhu kwenziwa ngokususa amanye amaseli abekiwe egazini lesiguli, uwaguqule elebhu bese uwajova kabusha esigulini. Ukwelashwa kwe-CAR T-cell kukhiqize imiphumela ekhuthazayo kakhulu kwi-Non-Hodgkin lymphoma futhi ngenxa yalokho yamukelwa FDA.

Amakhandidethi alungile okwelashwa kwe-CAR T-Cell 

Okwamanje FDA igunyaze ukwelashwa kwe-CAR T-Cell kwezinye izinhlobo zolaka neziphikisayo I-Non-Hodgkin lymphoma, i-Myeloma futhi ibuyele emuva futhi iphikisa i-leukemia enamandla ye-lymphoblastic. Isiguli sidinga ukuthumela imibiko yezokwelapha ephelele ukuze siqinisekise ukusetshenziswa kokwelashwa kwe-CAR T-Cell ekwelapheni kwaso.

Indlela yokufakwa yokwelashwa kwe-CAR T-cell:

1. Iziguli ezine-CD19 + B-cell Lymphoma (Okungenani ukuhlanganiswa kwangaphambili okungu-2 imiphumela emibi yokwelashwa ngamakhemikhali izinhlobo)

2.Ukuba neminyaka eyi-3 kuye kwengama-75

3. Isilinganiso se-ECOG ≤2

4. Abesifazane abanamandla okuthola izingane kumele babe nomchamo ukukhulelwa ukuhlolwa okwenziwe kwatholakala ukuthi une-negative ngaphambi kokwelashwa. Zonke iziguli ziyavuma ukusebenzisa izindlela ezithembekile zokuvimbela inzalo ngesikhathi sesilingo kuze kube kulandelwa okokugcina.

Izindlela zokukhishwa zokwelashwa kwe-CAR T-cell:

1.Ukuphakama komfutho wegazi ophakeme noma ukuquleka

2. Ukwehluleka kokuphefumula

3. Kusatshalaliswe i-coagulation ye-intravascular

4. I-Hematosepsis noma ukutheleleka okusebenzayo okungalawulwa

5. Okungalawulwa sikashukela

Izinzuzo zokwelashwa kwe-CAR T-Cell

1. > Amacala angama-5000 CAR T enziwe ngudokotela onamakhono kakhulu.
2. Izibhedlela eChina zenze izinhlobo eziningi zama-CAR T Cell kufaka phakathi i-CD19 & CD 22 kunanoma yiliphi elinye izwe emhlabeni.
3. I-China iqhuba izivivinyo zomtholampilo ezingaphezu kwama-300 ekwelashweni kwe-CAR T Cell. Ngaphezu kwanoma yiliphi elinye izwe emhlabeni.
4. Umphumela womtholampilo we-CAR T Cell uyefana nalowo wase-USA noma elinye izwe futhi kwesinye isikhathi ungcono.

Inqubo yokwelashwa yokwelashwa kwe-CAR T-Cell

• Qedela ukuhlolwa kwesiguli
• Iqoqo le-T-cell emzimbeni
• Ama-T-cell abese enziwa elebhu
• Ama-T-Cell akhiqizwe ngofuzo abese ephindaphindwa ngokuwasebenzisa akhule elabhorethri. Lawa maseli afriziwe abese ethunyelwa ezikhungweni zokwelashwa.
• Ngaphambi kokufaka, isiguli singanikezwa i-chemotherapy ngomdlavuza waso. Lokhu kusiza ukwelashwa kusebenze ngendlela engcono.
• Kungekudala ngemuva kokulashwa ngamakhemikhali i-CAR T-Cells ifakwa inqubo efana nokufakwa kwegazi.
• Kukhona inyanga yesi-2-3 yesikhathi sokululama kwesiguli.

Isikhathi esibekiwe sokwelashwa kwe-CAR T-Cell

1. Ukuhlolwa nokuhlolwa: isonto elilodwa

2. Pre-treatment & T-Cell Collection: isonto elilodwa

3. Ukulungiswa kweT-Cell nokubuyiselwa: amasonto amabili-amathathu

4. 1st Ukusebenza ngempumelelo: amasonto amathathu

5. Ukuhlaziywa kokuphumelela kwesibili: amasonto amathathu

Izindleko zokwelashwa kwe-CAR T-Cell e-Malaysia

Izindleko zokwelashwa kwe-CAR T-Cell e-Malaysia zizoba cishe phakathi $ 45000 - 50,000 USD. Ukuze uthole imininingwane ngemibandela yokufaneleka kanye nesilinganiso sezindleko sicela uthumele imibiko yakho yezokwelapha ku info@cancerfax.com ngegama lakho neminyaka yakho njengesihloko.

Funda nalokhu: Ukwelashwa kwe-CAR T Cell eNdiya 

Imiphumela emibi yokwelashwa kwe-CAR T-Cell

Imiphumela emibi ejwayelekile yokwelashwa kwe-CAR T-cell ifaka:

• I-Cytokine release syndrome
  Kwezinye izimo, iziguli zingaba nezimpawu ezinjengomkhuhlane, umkhuhlane, ikhanda elibuhlungu, isicanucanu, ukuhlanza, izitulo ezixegayo, nobuhlungu bemisipha noma obuhlangene. Kungadala nomfutho wegazi ophansi, ubunzima bokuphefumula, nokushaya kwenhliziyo okusheshayo. Le miphumela emibi ibangelwa ukukhishwa kwama-cytokines amaseli omzimba ngesikhathi sokwelashwa kwe-CAR T-cell. Lezi zimpawu zivame ukuba mnene, kepha zingaba zimbi futhi zisongele impilo kwezinye iziguli.
• Imicimbi yezinzwa
  Imicimbi ye-neurological ingenzeka futhi ingaba yimbi kwezinye iziguli. Imicimbi enjalo ifaka i-encephalopathy (ukulimala kwengqondo nokungasebenzi kahle), ukudideka, ukukhuluma kanzima, ukukhathazeka, ukuquleka, ukozela, ukushintsha kwesimo sokwazi nokulahlekelwa ibhalansi.
• I-Neutropaenia ne-Anemia
  Ezinye iziguli zingakha i-neutropenia noma isibalo samaseli amhlophe aphansi.  Ngokufanayo, i-anemia noma ukubalwa kwamaseli abomvu aphansi kungenzeka futhi ngenxa yalokhu kwelashwa.
  Ngenhlanhla, iningi lalemiphumela emibi ivame ukuzixazululela yodwa noma ingalawulwa ngokusetshenziswa kwe-  imithi.

Luphumelela kangakanani ukwelashwa kwe-CAR T-Cell?

Ukwelashwa kwe-CAR T-cell ekwelapheni i-lymphoma namanye amagciwane egazi kubonise imiphumela ethembisayo. Kusukela ekwelashweni kwe-CAR T-cell, iziguli eziningi ezazibuye zibuyele emuva izicubu zegazi zazinemiphumela ethembisayo futhi zingenabo ubufakazi bomdlavuza. Iphinde yasiza ekuvuseleleni iziguli esezihlulekile ngaphambilini ukuphendula kuningi lokwelashwa kwendabuko komdlavuza.

Kodwa-ke, izifundo zesikhathi eside zesibalo esikhulu sesiguli ziyadingeka ukuqinisekisa ukusebenza kwalokhu kwelashwa. Ukuhlolwa okukhulu kuzosiza ekutholeni amathuba okuba nemiphumela engemihle nezindlela ezifanele zokubhekana nayo.

Izibhedlela ezihlinzeka nge-CAR T-cell therapy eMalaysia

• I-Sunway Medical Centre, eSelangor
• Columbia Asia Hospital, Kuala Lumpur

Ngingakuthola kanjani ukwelashwa e-Malaysia?

Isiguli singashayela +91 96 1588 1588 noma nge-imeyili ku cancerfax@gmail.com ngemininingwane yesiguli nemibiko yezokwelapha futhi sizohlela ukuthola umbono wesibili, uhlelo lokwelashwa kanye nokulinganiselwa kwezindleko.