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High CR rates are overcome by CD22-directed CAR T-Cell therapy against CD19 relapse in LBCL

In February 2023, a phase 1 trial at a single institution found that it was safe and possible for people with heavily pretreated large B-cell lymphoma (LBCL) to use CD22-directed chimeric antigen rec...
large-b-cell-lymphoma

Novel treatment target for lymphoma patients who relapse after CAR-T therapy

Feb 2023: The results of the trial demonstrated that a novel chimeric antigen receptor T-cell therapy elicited a response in adults with advanced large B-cell lymphoma who had relapsed following prio...
large-b-cell-lymphoma

Lisocabtagene maraleucel is approved by FDA for second-line treatment of large B-cell lymphoma

July 2022:  Lisocabtagene maraleucel (Breyanzi, Juno Therapeutics, Inc.) has been approved by the Food and Drug Administration for adult patients with large B-cell lymphoma (LBCL) who have refractor...
large-b-cell-lymphoma

JW Therapeutics’ IND is cleared by China NMPA for CAR T-Cell therapy in large B-Cell lymphoma

China's National Medical Products Administration (NMPA) has approved JW Therapeutics' investigational new drug (IND) application for a key clinical trial of Carteyva (relmacabtagene autoleucel) in peo...
large-b-cell-lymphoma

The FDA has granted loncastuximab tesirine-lpyl accelerated approval for large B-cell lymphoma

August 2021: The FDA granted loncastuximab tesirine-lpyl (Zynlonta, ADC Therapeutics SA), a CD19-directed antibody and alkylating agent conjugate, accelerated approval for adult patients with relapsed...
large-b-cell-lymphoma

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