Category: Gastric cancer

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Satri-cel CAR T-Cell Therapy: A New Era in Gastric Cancer Treatment

CAR T Cell therapy for gastric cancer The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting introduced an important new cancer treatment: Satricabtagene autoleucel (satri-cel), a CAR T...

Pembrolizumab is approved by the USFDA for HER2 positive gastric or gastroesophageal junction adenocarcinoma expressing PD-L1 (CPS ≥1)

On March 19, 2025, the Food and Drug Administration officially approved pembrolizumab (Keytruda, Merck) to be used along with trastuzumab and chemotherapy that includes fluoropyrimidine and platinum f...

Zolbetuximab-clzb with chemotherapy is approved by the USFDA for gastric or gastroesophageal junction adenocarcinoma

 On October 18, 2024, the Food and Drug Administration sanctioned zolbetuximab-clzb (Vyloy, Astellas Pharma US, Inc.), a claudin 18.2 (CLDN18.2)-targeted cytolytic antibody, in conjunction with fluor...

Pembrolizumab with chemotherapy is approved by the USFDA for HER2-negative gastric or gastroesophageal junction adenocarcinoma

The Food and Drug Administration approved pembrolizumab (Keytruda, Merck) in combination with fluoropyrimidine- and platinum-containing chemotherapy on November 16, 2023. This approval is for the ini...

FDA revises pembrolizumab’s indication for gastric cancer

The Food and Drug Administration updated the approved use of pembrolizumab (Keytruda, Merck) in combination with trastuzumab, fluoropyrimidine, and platinum-containing chemotherapy for treating HER2...

Claudin 18.2 and its role in advanced gastric cancers

August 2022: The most apical portion of polarized epithelial and endothelial cells contains tight junctions, which are specialized membrane domains. The claudins, which are important proteins in tigh...

Nivolumab has been approved by the FDA for resected esophageal or gastroesophageal junction cancer

August 2021: The FDA has approved Nivolumab (Opdivo, Bristol-Myers Squibb Company) for patients with fully resected oesophagus or gastroesophageal junction (GEJ) cancer who have received neoadjuvant c...

Pembrolizumab receives accelerated approval from the FDA for HER2-positive gastric cancer

August 2021: Pembrolizumab (Keytruda, Merck & Co.) in combination with trastuzumab, fluoropyrimidine-, and platinum-containing chemotherapy has been granted accelerated approval by the Food and Dr...

Nivolumab in addition to chemotherapy is approved by FDA for metastatic gastric cancer and esophageal adenocarcinoma

August 2021: For advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma, the Food and Drug Administration approved nivolumab (Opdivo, Bristol-Myers Squi...

Pembrolizumab has been approved by the FDA for the treatment of esophageal or gastroesophageal junction cancer

August 2021: Pembrolizumab (Keytruda, Merck Sharp & Dohme Corp.) in combination with platinum and fluoropyrimidine-based chemotherapy has been approved by the Food and Drug Administration for pati...

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