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Remestemcel-L-rknd is approved by the USFDA for steroid-refractory acute graft versus host disease in pediatric patients

On December 18, 2024, the Food and Drug Administration sanctioned remestemcel-L-rknd (Ryoncil, Mesoblast, Inc.), an allogeneic bone marrow-derived mesenchymal stromal cell (MSC) therapy, for steroid-r...

Enhancing Cancer Outcomes: The Critical Role of Early CAR T-Cell Therapy

Cancer remains one of the most challenging diseases to treat, requiring innovative and effective therapies. One of the most promising advancements in cancer treatment is Chimeric Antigen Receptor (CA...

Obecabtagene autoleucel for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia

On November 8, 2024, the Food and Drug Administration sanctioned obecabtagene autoleucel (Aucatzyl, Autolus Inc.), a CD19-targeted genetically engineered autologous CAR T cell therapy, for people with...

Latest therapies in the treatment of hematological malignancies

 IntroductionHematological malignancies, such as leukemias, lymphomas, and multiple myeloma, are a heterogeneous group of cancers that arise in the bone marrow and lymphatic system. Conventional trea...

Bridging The Gaps In CAR T Cell therapy

 CAR T Cell therapyChimeric Antigen Receptor (CAR) T-cell therapy is a revolutionary therapeutic strategy in hematologic malignancy treatment, recording high remission rates in therapy-refractory cas...

Personalized T-Cell therapies in the treatment of hematological malignancies

 IntroductionCancer is still one of the most difficult diseases to cure, and conventional treatments such as chemotherapy, radiation, and surgery have yielded limited success and severe side effects....

Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

 CAR immune Cell therapyChimeric Antigen Receptor (CAR) immune cell therapy has transformed the treatment of cancer, especially for hematological cancers. Its effectiveness notwithstanding, it still ...

How to prevent infections in patients receiving CD19-targeted chimeric antigen receptor T cells for B-cell malignancies?

 CAR T Cell therapyChimeric Antigen Receptor (CAR) T-cell therapy has changed the face of treating B-cell malignancies, and it has provided hope to those with relapsed or refractory disease. Through ...

Donor T cells for CAR T cell therapy

 CAR T Cell therapyChimeric Antigen Receptor (CAR) T cell therapy has transformed cancer treatment by genetically modifying a patient's own T cells to target and destroy cancer cells. Although this a...

Strategies to optimize chimeric antigen receptor T-cell therapy in hematologic malignancies: Experience from China

 CAR T Cell therapyChimeric Antigen Receptor (CAR) T-cell therapy has changed the course of treatment for numerous hematologic malignancies like leukemia, lymphoma, and multiple myeloma. China is at ...

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