Ucwaningo olusha lubonisa ukuthi ku iziguli ezine isibindi noma isibindi esibusayo umdlavuza we-metastatic colorectal , ukwengezwa kokwelashwa okukhethekile kwemisebe yangaphakathi ekwelapheni ngamakhemikhali komugqa wokuqala we-mFOLFOX6 kuphumela ekwenyukeni okukhulu kokusinda kweziguli ezinezimila eziyinhloko kwesokudla.
I-SIRT, esetshenziswe eYurophu kusukela ngo-2003, iyinhlangano i-radiotherapy yangaphakathi usebenzisa Ama-microspheres we-Y-90 resin (ububanzi obuphakathi kwama-microns angama-20 no-60) kuhanjiswa emthanjeni we-hepatic kusetshenziswa i-catheter . Ama-microsphere akhipha imisebe ye-Beta afakwa ngokukhethekile kuma-microvessel azungeze isimila, okunciphisa imiphumela yesistimu.
Izifundo zomhlaba wonke ze-SIRFLOX, FOXFIRE kanye ne-FOXFIRE zihloselwe ukuhlola ukusebenza kahle nokuphepha kwe-SIRT kanye nomugqa wokuqala we-oxaliplatin chemotherapy ye-mCRC engasahleki.
Ezigulini ezingama-554 ezathola ukwelashwa ngamakhemikhali kanye ne-SIRT kanye neziguli ezingama-549 ezathola ukwelashwa ngamakhemikhali kuphela, imiphumela yabonisa ukuthi isikhathi esimaphakathi sokusinda kwesimila esingakwesokunxele seziguli ze-mCRC ku-chemotherapy kanye neqembu le-SIRT kwakuyizinyanga ezingama-24.6, uma kuqhathaniswa nezinyanga ezingama-26.6 eqenjini le-chemotherapy kuphela. , kodwa i-SIRT chemotherapy Ukusinda okumaphakathi kweziguli ze-mCRC ezinamathumba ahlangene kwakuyizinyanga ezingu-22 eqenjini kanye nezinyanga ezingu-17.1 eqenjini le-chemotherapy kuphela, okwakuyizinyanga ezingu-5 ubude.
Esithangamini sabezindaba, uDkt. Harpreet Wasan utshele i-Imperial College Health Care NHS Trust e-UK ukuthi umbono uwukuthi umdlavuza oseceleni kwesokudla awugcini nje ngokuba mkhulu […] kodwa umelana kakhulu ne-chemotherapy. Bangase bazwele kakhulu ekwelapheni ngemisebe, okunendlela yokusebenza ehluke ngokuphelele.
UDkt Wasan wanezela ukuthi ukuntuleka kwemiphumela emihle ekuhlaziyeni jikelele kungase kube ngenxa yokufakwa kweziguli ezinomdlavuza we-metastatic ngaphandle kwesibindi. Uthe: “Nakuba i-SIRT ikwazi ukulawula izifo zesibindi, ayikwazi ukulawula izifo ngaphandle kwesibindi.”
