Brukinsa zanubrutinib

Disemba 2021: I-BRUKINSA (Zanubrutrinib) isidakamizwa esivela kudokotela I-BeiGene Ltd. I-BRUKINSA isetshenziselwa ukwelapha abantu abadala abane-Mantle cell lymphoma (MCL), i-macroglobulinemia ka-Waldenström (WM) kanye ne-marginal zone lymphoma (MZL) abaye baba okungenani eyodwa ngaphambi umdlavuza ukwelashwa. I-macroglobulinemia ka-Waldenström iwuhlobo lwe-macroglobulinemia ebangelwa i-Waldenström's (WM). Iziguli zingakwazi thenga i-Brukinsa online.

Uma ithathwa ngenani eliphelele lansuku zonke eligunyaziwe le-320 mg, i-BRUKINSA® (zanubrutinib) itholakale ivimbela amaphesenti angu-100 we-BTK kumaseli egazi kanye namaphesenti angu-94 kuya kumaphesenti angu-100 e-BTK kuma-lymph nodes. Umthelela wokuvimbela ngokuphelele i-BTK emiphumeleni yokwelashwa usazonqunywa.

I-BRUKINSA iwukwelashwa kwabantu abaye baba nokwelashwa okungenani okukodwa kwangaphambili kwe-mantle cell lymphoma (MCL).

Ukugunyazwa kwe-BRUKINSA bekusekelwe esilinganisweni sokuphendula. Lokhu kusetshenziswa kusahlolwa ukuze kubonakale ukuthi akunayo yini inzuzo yomtholampilo. I-BRUKINSA akwaziwa ukuthi iphephile noma iyasebenza ezinganeni.

Iphrotheni ye-Bruton's tyrosine kinase (BTK) ihlotshaniswe ne-MCL.

Kungani i-BTK inhibitor iwusizo ekwelapheni i-mantle cell lymphoma (MCL)?

I-MCL ibangelwa ama-B cell abulalayo ayanda futhi asakazeke ngokushesha.
I-BTK (i-Bruton's tyrosine kinase) iphrotheni esiza amaseli B ayingozi ukuthi akhule futhi asakazeke ngokuthumela amasignali kuwo.
Ukuvinjwa kwe-BTK kungasiza ukuvimbela lokhu kusayina.
Umthelela wokuvimbela ngokuphelele i-BTK emiphumeleni yokwelashwa usazonqunywa.

I-Brukinsa isebenza kahle kangakanani?

Ezifundweni ezi-2 zomtholampilo, Iziguli ze-118 abane-MCL bathole i-BRUKINSA ngemva kokungenani ukwelashwa oku-1 kwangaphambilini. Kuzo zombili izifundo zomtholampilo, iziguli ezingama-84% ziphendule ekwelashweni, okwaziwa ngokuthi izinga lokuphendula lilonke futhi cishe ama-80% aqhubeka nokuphendula unyaka noma ngaphezulu. 

Yimiphi imiphumela emibi engaba khona yeBrukinsa?

I-BRUKINSA ingase ibangele imiphumela emibi kakhulu, okuhlanganisa:

Ukuphefumula inkinga yokopha eyingozi engaholela ekufeni. Uma futhi uthatha umuthi onciphisa igazi, ingozi yakho yokopha ingase ikhule. Uma unezimpawu noma izimpawu zokopha, tshela udokotela wakho, okuhlanganisa:

• igazi ezindleleni zakho noma ezindle ezimnyama (kubukeka njengetiyela)
• umchamo obomvana noma onsundu
• ukopha okungalindelekile, noma ukopha okukhulu noma ongakwazi ukukulawula
• hlanza igazi noma ukuhlanza okubukeka njengezindawo zekhofi
• khwehlela igazi noma amahlule egazi
• ukulimala okwandayo
• isiyezi
• ebuthakathakeni
• ukudideka
• izinguquko enkulumeni yakho
• ikhanda elibuhlungu elihlala isikhathi eside.

Izifo lokho kungaba kubi futhi kungaholela ekufeni. Tshela umhlinzeki wakho wezempilo ngokushesha uma unomkhuhlane, ukugodola, noma izimpawu ezinjengomkhuhlane.

• Ukwehla kokubalwa kwamaseli egazi. Ukuncipha kwenani legazi (amangqamuzana amhlophe egazi, amaplatelet, namaseli abomvu egazi) kuvamile nge-BRUKINSA, kodwa futhi kungaba nzima. Umhlinzeki wakho wokunakekelwa kwezempilo kufanele enze ukuhlolwa kwegazi ngesikhathi sokwelashwa nge-BRUKINSA ukuze ahlole izibalo zakho zegazi.
• Umdlavuza wesibili oyinhloko. Sekwenzeke imidlavuza emisha kubantu ngesikhathi belashwa nge-BRUKINSA, okuhlanganisa nomdlavuza wesikhumba. Sebenzisa isivikelo elangeni uma ungaphandle elangeni.
• Izinkinga zesigqi senhliziyo (i-atrial fibrillation kanye ne-atrial flutter). Tshela umhlinzeki wakho wokunakekelwa kwezempilo uma unesinye salezi zimpawu noma izimpawu ezilandelayo:
  
  • ukushaya kwenhliziyo yakho kuyashesha noma akuvamile
  • uzizwe unekhanda elilula noma unesiyezi
  • quleka (faint)
  • ukuphelelwa umoya
  • Ukungaphatheki kahle kwesifuba

I-Brukinsa ithathwa kanjani?

Umthamo onconyiwe we-BRUKINSA ngu-320 mg nsuku zonke, okungamaphilisi amane angama-80-mg. Udokotela wakho angancoma ukuthatha i-BRUKINSA: kabili ngosuku noma kanye ngosuku.

Amaphilisi e-BRUKINSA kufanele aphuzwe egcwele ngamanzi—angavuli, awaphuki, noma awahlafune. I-BRUKINSA ingathathwa ngokudla noma ngaphandle kokudla.

Umthamo wakho nohlelo lungashintshwa noma luphazamiseke ngodokotela wakho ukuze uhlangabezane nezidingo zakho zokwelashwa ngakunye okuhlanganisa nokuphatha imiphumela engemihle.

Imvume 

Ukuvunyelwa kusukela ngoDisemba 2021.

I-BRUKINSA ivunyelwe kulezi zinkomba nezifunda ezilandelayo:

• Ukwelashwa kwe-mantle cell lymphoma (MCL) ezigulini zabantu abadala ezithole okungenani ukwelashwa okukodwa kwangaphambili (i-United States, Novemba 2019)^a;
• Okokwelashwa kwe-MCL ezigulini zabantu abadala ezithole okungenani ukwelashwa okukodwa kwangaphambili (China, June 2020) ^b;
• Ukwelashwa kwe-lymphocytic leukemia (CLL) noma i-lymphocytic lymphoma encane (SLL) ezigulini ezikhulile ezithole okungenani ukwelashwa okukodwa kwangaphambili (China, June 2020) ^b;
• Okokwelashwa kwe-MCL ebuyele emuva noma ehlanekezelwe (United Arab Emirates, February 2021);
• Okokwelashwa kwe-Waldenström's macroglobulinemia (WM) ezigulini zabantu abadala (Canada, March 2021);
• Okokwelashwa kweziguli ezikhulile ezine-WM ezithole okungenani ukwelashwa okukodwa kwangaphambili (China, Juni 2021)^b;
• Okokwelashwa kwe-MCL ezigulini zabantu abadala ezithole okungenani ukwelashwa okukodwa kwangaphambili (Canada, July 2021);
• Okokwelashwa kwe-MCL ezigulini zabantu abadala ezithole okungenani ukwelashwa okukodwa kwangaphambili (eChile, Julayi 2021);
• Okokwelashwa kweziguli ezikhulile ezine-MCL ezithole okungenani ukwelashwa okukodwa kwangaphambilini (i-Brazil, Agasti 2021);
• Okokwelashwa kweziguli zabantu abadala nge-WM (United States, Agasti 2021);
• Okokwelashwa kweziguli ezikhulile ezine-marginal zone lymphoma (MZL) ezithole okungenani uhlobo olulodwa olusekelwe ku-CD20 (United States, September 2021)*;
• Okokwelashwa kweziguli zabantu abadala ezine-MCL ezithole okungenani ukwelashwa okukodwa kwangaphambilini (eSingapore, Okthoba 2021);
• Okokwelashwa kwe-MCL ezigulini ezithole okungenani ukwelashwa okukodwa kwangaphambili (Israel, October 2021);
• Okokwelashwa kweziguli zabantu abadala abane-WM ezithole okungenani ukwelashwa okukodwa kwangaphambili, noma ukwelashwa komugqa wokuqala ezigulini ezingafaneleki i-chemo-immunotherapy (Australia, October 2021);
• Okokwelashwa kweziguli ezikhulile ezine-MCL ezithole okungenani ukwelashwa okukodwa kwangaphambili (Australia, October 2021);
• Okokwelashwa kweziguli ezikhulile ezine-MCL ezithole okungenani ukwelashwa okukodwa kwangaphambilini (eRussia, Okthoba 2021);
• Okokwelashwa kwe-mantle cell lymphoma (MCL) ezigulini ezikhulile ezithole okungenani ukwelashwa okukodwa kwangaphambili (Saudi Arabia, November 2021); futhi
• Okokwelashwa kweziguli ezikhulile ezine-WM ezithole okungenani ukwelashwa okukodwa kwangaphambili noma ukwelashwa komugqa wokuqala kweziguli ezingafaneleki i-chemo-immunotherapy (European Union, November 2021).

Intengo yaseBrukinsa eNdiya

The izindleko ze-Brukinsa oral capsule 80 mg iphakathi $ 3500-4000 ukuze uthole ama-capsules angu-120, kuye ngekhemisi olivakashelayo.

Ngingayithenga i-Brukinsa ku-inthanethi?

Yebo, ungathenga iBrukinsa online. Amakhemisi amaningi aku-inthanethi ayithengisa ku-inthanethi kodwa ngemiyalelo evumelekile kuphela.

Ukuze uthole olunye ulwazi sicela ushayele, umlayezo noma WhatsApp +91 961588 1588.

Sicela uchofoze lapha ukuze uthole imininingwane ye-Brukinsa.