World Cancer Day 2022

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4th Feb 2022: In India, cancer can have serious social and economic effects, typically resulting in family destitution and societal injustice. In this demographically young country, reported age-adjusted cancer incidence rates are still fairly low. In a population of 1.3 billion people, slightly more than 1 million new instances of cancer are detected each year. In age-adjusted terms, this reflects around a fourth of the male and female incidence seen in Western Europe. Cancer, on the other hand, was responsible for an estimated 600000–700000 fatalities in India in 2012.

World cancer day 2022

According to the IHME study’s Global Burden of Disease Study 2019 analysis, the picture is not particularly different globally. In 2019, the number of new cancer cases surpassed 23 million, up from 18.7 million in 2010. In 2019, there were 10 million cancer deaths, up from 8.29 million in 2010. These results show a 20.9 percent and a 26.3 percent increase, respectively.
In both developing and developed countries, cancer is a leading cause of morbidity and mortality. The majority of the population in many low- and middle-income nations, including India, does not have access to a well-organized and well-regulated cancer care system. When a person is diagnosed with cancer, they are often forced to spend a lot of money on their own health. Such expenses can push entire families into poverty and, when paired with a lack of what are considered acceptable services, can jeopardize social stability. It can be easily said that cancer treatment in India is still in a nascent stage and huge development is required in this field.
There are two major problems cancer patients and their family members face when someone is diagnosed with cancer. One is, where will they get the best and most appropriate treatment, and two, how much money will be required for treatment? Second is the most important question, as the general population in India is still devoid of health insurance. We at CancerFax addresses both these problems. We help cancer patients find most appropriate and economical cancer treatment in India and abroad. CancerFax is working with more than 100 top cancer hospitals in 10 countries like Dana-Farber, Mayo Clinic, Boston Children’s Hospital, Sheba, Asan, Apollo, BLK, Artemis to name a few.

World cancer day-article

CAR T-Cell therapy is a breakthrough treatment for some kinds of lymphoma, leukemia and multiple myeloma. CancerFax helps patients enroll for CAR T-Cell therapy treatment in the USA, Israel and China. Many patients who had previously relapsed blood tumors had no evidence of cancer after CAR T-Cell therapy. It has also aided in the rehabilitation of patients who have previously failed to respond to most traditional cancer therapies. There are more than 300 ongoing clinical trials in the world’s leading cancer centers on this therapy. CAR T-Cell therapy in India is available as clinical trials now. I hope it will be available for commercial treatment very soon.

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Targeting FGFR4 and CD276 with CAR T-cells demonstrates a strong antitumor impact against children rhabdomyosarcoma
CAR T-Cell therapy

Targeting FGFR4 and CD276 with CAR T-cells demonstrates a strong antitumor impact against children rhabdomyosarcoma

Chimeric antigen receptor (CAR) T-cells that specifically target Fibroblast Growth Factor Receptor 4 (FGFR4), a surface tyrosine receptor that is extensively expressed in rhabdomyosarcoma (RMS), are now undergoing clinical research. However, the effectiveness of these CAR T-cells may be hindered by tumor heterogeneity and inadequate activation. In this study, we present a method to enhance the co-stimulatory and targeting characteristics of a FGFR4 CAR through an optimization process. We substituted the hinge and transmembrane domain of CD8 as well as the 4-1BB co-stimulatory domain with the corresponding domains of CD28. The CARs produced exhibit heightened anti-tumor efficacy in multiple RMS xenograft models, with the exception of the RMS559 cell line, which is known for its aggressive nature.

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