Strategy for cervical cancer screening

Since the 1960s, due to the popularity of screening, cervical cancer deaths have declined significantly. In the United States, cervical cancer is the 18th most common cause of cancer deaths. It is expected that there will be 13,240 new cases in 2018, including 4,170 deaths. Most deaths from cervical cancer occur in people who are not adequately screened. Women in low-income communities, women of color, and women living in remote or rural areas make up these deaths related to cervical cancer.

The United States Preventive Services Task Force (USPSTF) provides new recommendations for cervical cancer screening and provides women with more testing options. The biggest change is that women between the ages of 30-65 can choose to completely abandon cervical smears. New evidence shows that human papillomavirus (HPV) is sexually transmitted and almost all cervical cancer is caused by HPV. HPV causes changes in cervical cells, which can lead to cervical cancer. Women aged 30-65 years can choose to have an HPV test every five years to screen for cervical cancer, instead of having a cervical smear every three years. Avoid unnecessary tests. Thus avoiding additional costs and more follow-up problems. This is the first time that a separate HPV test is recommended to screen for cervical cancer, and this test is recommended regardless of sexual history. But Bruder predicts that Pap smears will not be replaced soon.

In the past, the recommendation for women of this age group was a cervical smear, also known as exfoliative cytology, a cervical smear every three years or combined with an HPV test every five years (co-testing). Women can still choose to use this method to screen for cervical cancer. For women aged 21-29, it is still recommended to have a Pap smear every three years. It is not recommended for women under 21 years of age because cervical cancer under the age of 21 is rare. Similarly, women who are adequately screened for cervical cancer over the age of 65 do not need to be tested. Those who are over 65 years old and have had 3 cervical smears or 2 joint examinations have no adverse results, nor have they had any adverse results in the past 10 years, and they no longer need to undergo cervical cancer screening, even if they have a new sex partner . The new guidelines are only for women who do not have any bad test results. People who have been diagnosed with highly premalignant lesions or cervical cancer should consult their doctor to discuss their detection methods.

Susan Hau is a distinguished researcher in the field of cancer cell therapy, with a particular focus on T cell-based approaches and cancer vaccines. Her work spans several innovative treatment modalities, including CAR T-cell therapy, TIL (Tumor-Infiltrating Lymphocyte) therapy, and NK (Natural Killer) cell therapy.

Hau's expertise lies in cancer cell biology, where she has made significant contributions to understanding the complex interactions between immune cells and tumors.

Her research aims to enhance the efficacy of immunotherapies by manipulating the tumor microenvironment and exploring novel ways to activate and direct immune responses against cancer cells.

Throughout her career, Hau has collaborated with leading professors and researchers in the field of cancer treatment, both in the United States and China.

These international experiences have broadened her perspective and contributed to her innovative approach to cancer therapy development.

Hau's work is particularly focused on addressing the challenges of treating advanced and metastatic cancers. She has been involved in clinical trials evaluating the safety and efficacy of various immunotherapy approaches, including the promising Gamma Delta T cell therapy.

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  • April 26th, 2020

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