Tananka pointed out: “These data initially show the relationship between TLL1 / Tll1 expression and hepatic stellate cell activation or hepatic fibrosis progression in animals or in vitro and in humans (the model is non-alcoholic steatohepatitis-related liver cancer). It may be able to clarify a new mechanism of liver fibrosis or canceration. After the patient received radical treatment for hepatitis C virus and obtained SVR, TLL1 SNP-related experiments may be used to identify people at risk of liver cancer. If TLL1 SNP is compared with The combination of age, degree of fibrosis, high alpha-fetoprotein level and other significant risk factors can help clinically predict the risk of liver cancer after SVR. No interferon oral treatment plan combined with direct-acting antiviral drug therapy , Is becoming the standard anti-hepatitis C virus therapy in developed countries. However, further research is still needed to assess whether TLL1 mutations are related to the occurrence of liver cancer after treatment with interferon-free SVR.
Niraparib and abiraterone acetate plus prednisone is approved by FDA for BRCA-mutated metastatic castration-resistant prostate cancer
The Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined by an FDA-approved test.