Brittiläiset tutkijat aloittavat lapsuuden kasvainten geenitestauksen. Brittiläiset tutkijat toivovat, että geenitestaus antaa nuoremmille potilaille uudempia ja yksilöllisempiä hoitoja, jotka lisäävät heidän selviytymistään. Uusi testi analysoi 81 erilaista syövän geneettistä muutosta.
Scientists say the test will lead to “a higher level of playing field” and accelerate children’s access to important new drug treatments. The test was performed at the Royal Marsden National Health System Hospital in London and will be tested on 400 children from all over the UK over the next two years.
The test has been implemented with genetic funding from the National Institutes of Health (NIHR) foundation and the Syöpä Institute. A charity called Christopher has provided more than £ 300,000 in funding to develop the test. The organization was founded by a couple whose children died of invasive aivokasvaimet kuuden vuoden iässä.
This is a real first step towards personalized syövän hoitoon for children,” said Christopher’s parents, Karen and Kevin Capel. Christopher got a generic kasvain. Hopefully, in the future, children will know exactly what type of tumor they have.” “We almost feel that the treatment for the child is not to kill the cancer, but to kill our child.”
“He used to be a healthy, happy, very athletic 4-year-old kid. But he became unable to speak or even eat on his own, and lost weight. “In the year he was diagnosed, he was unable to grow into a child of his age. We tried to keep him from other children.”
Pahanlaatuiset kasvaimet ovat hyvin harvinaisia lapsilla, potilaspopulaatioita ei ole paljon, ja kliinisiä tutkimuksia for pharmaceutical companies will lack motivation. This means that children will miss the opportunity to receive targeted treatments for cancer cells without damaging healthy cells with innovative therapies.
Professor Louis Chesler, who is leading the genetic testing research, said: “Children often don’t have equal access to the most advanced and potentially beneficial cancer treatments.” “The cost of developing gene-targeted drugs is very high. They tend to Test it on adults first so that more people can get treatment and the results can be seen faster. ”
"Tämä testi on uskomaton edistysaskel, koska se tunnistaa hyvin selvästi kaikki kasvaimen geneettiset muutokset." "Geenitestaus antaa lääkäreille erittäin tehokkaan työkalun - auttaa heitä valitsemaan lapsilleen oikean lääkkeen ja tekemään parhaansa. Näiden lääkkeiden tehokkuus voi olla mahdollista määrittää nopeasti. ”
Children’s tumors are usually genetically simpler than adult tumors, so eventually these drugs may be more effective in children.” The goal of geenitestaus is to give scientists and doctors detailed genes for childhood tumors within a few weeks of diagnosis. information.
Genetic testing gives doctors strong evidence to use kohdennetut terapiat for younger patients, potentially preventing these patients from experiencing the side effects associated with traditional chemotherapy and radiation therapy.
Jack Daly, 14, from Wokingham, was diagnosed with a brain tumor when he was 7 and is now a brain tumor perhe. Radiotherapy helped save his life, but left him with sequelae. “My athletic ability is not very good,” Jack said. “I have to get someone to help me dress and undress at school.” “My balance is not good-I am awkward and often fall. I worked hard at school, where I found friendship.” Jack and his mother, Helen, use their donations to make ends meet in Capels-hoping that geenitestaus will make a huge difference in the quality of life of future children.
"Ihmiset eivät todellakaan näe ongelmaa, koska Jack on toipunut syövästä. Hänen ei tarvitse olla pyörätuolissa. Hänen ei tarvitse käyttää sidettä ”, Helen sanoi.
"Jos olet koskaan nähnyt Jackia, hän näyttää normaalilta teini-ikäiseltä pojalta. Mutta mitä et näe, on hoidon aiheuttama aivokudosvaurio. "
Tämän artikkelin lähde-URL: http://www.bbc.com/news/health-35918744
