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I-Oricell inyusa u-$45M USD owengeziwe ukuze inwebise ukwelashwa kwayo kwe-CAR T-Cell iye e-United States

I-Oricell Therapeutics
U-Oricell wenza inqwaba yemithi yokwelapha ye-CAR-T kanye nama-antibody amathumba aqinile. Ocwaningweni lweSigaba I okwethulwe kwa-ASCO, iqembu leziguli ezine-myeloma eminingi engazweli ekwelashweni libe nesilinganiso sokuphendula esiyi-100% kanye nempendulo eqinile engu-60% ku-CAR-T ka-Oricell eqondiswe ku-GPRC5D.

Yabelana ngalokhu okuthunyelwe

23 Mashi 2023: Izindlela zokwelapha i-preclinical kanye nesigaba sokuqala somdlavuza ezithuthukiswa yi-Shanghai biotech Oricell bathole enye imali eyizigidi ezingama-45 zamaRandi, kumemezele inkampani ngoLwesibili.

Ngemva kokuboniswa e-ASCO ngonyaka odlule ngokwelashwa kwe-CAR-T eqondiswe yi-GPRC5D ye-myeloma eminingi, u-Oricell ukhulise uchungechunge lwe-B oluyizigidi ezingu-$ 120 ngoJulayi. Abatshalizimali abasha i-Qiming Venture Partners kanye ne-C&D Emerging Industry Equity Investment elandelwa abatshalizimali abakhona i-RTW Investments kanye neQatar Investment Authority ihole ekunyusweni kwakamuva, okuwukukhula kwalowo mzuliswano.

Inkampani ye-biotech yathi izimali ezisanda kutholwa zizosetshenziselwa ikakhulukazi ucwaningo lwezokwelapha e-US.

U-Oricell usebenza eziningana Izindlela zokwelapha ze-CAR-T and solid tumour antibody candidates. A group of patients with treatment-resistant i-myeloma eminingi responded to Oricell’s GPRC5D-directed CAR-T with a 100% overall response rate and 60% stringent complete response in the Phase I trial that was presented at ASCO.

Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell eChina

Ikakhulukazi, u-Oricell waqokomisa iqembu leziguli ezinhlanu ezazivele zithole i-BCMA I-CAR-T yokwelapha. Ngokusho kwenkampani, impendulo eyodwa engaphelele, "izimpendulo ezinhle kakhulu eziyingxenye," kanye nezimpendulo ezimbili eziqinile zonke zamukelwe. Futhi ngokulandela okumaphakathi okusuka ezinsukwini ezingama-35 kuye kwezingama-281, zonke bezingenanqubekela phambili ngosuku lokuvala e-ASCO.

Ngokusho kuka-Oricell, okwamanje osesigabeni sokuvumela i-IND, inethemba lokwelula ukuhlolwa kokwelashwa kwayo kwe-CAR-T eqondiswe yi-GPRC5D ukuya e-US.

Ngaphezu kwalokho, i-Oricell inokwelashwa kweseli ye-CAR-T eqondiswe yi-GPC3 ebizwa ngokuthi i-Ori-C101, ecwaninga nge-advanced hepatocellular carcinoma.

Ukwelashwa kwe-CAR T-Cell is among the breakthrough treatments for certain types of blood cancers. There are more than 750 ongoing izivivinyo zokwelashwa in CAR T-Cell therapy in China at present. Patients who wish to enroll can contact the ICancerFax inombolo yosizo yesiguli ku-WhatsApp +91 96 1588 1588 noma nge-imeyili ku info@cancerfax.com.

I-CAR T-Cell Therapy e-China: Ukuguqula Ukwelashwa Komdlavuza

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Ukwelashwa kwe-CAR T-Cell

I-CAR T Cell Therapy Esekelwe Kubantu: Ukuphumelela kanye Nezinselele

Ukwelashwa kwe-CAR T-cell okusekelwe kumuntu kuguqula ukwelashwa komdlavuza ngokushintsha izakhi zofuzo amaseli omzimba esiguli ukuze aqondise futhi abhubhise amaseli omdlavuza. Ngokusebenzisa amandla esimiso somzimba sokuzivikela ezifweni, lezi zindlela zokwelapha zinikeza ukwelashwa okunamandla futhi okuqondene nomuntu okungahle kube nokuxolelwa okuhlala isikhathi eside ezinhlotsheni ezihlukahlukene zomdlavuza.

admin Kwangathi 4, 2024
Ukuqonda I-Cytokine Release Syndrome: Izimbangela, Izimpawu, Nokwelashwa
Ukwelashwa kwe-CAR T-Cell

Ukuqonda I-Cytokine Release Syndrome: Izimbangela, Izimpawu, Nokwelashwa

I-Cytokine Release Syndrome (CRS) iwukusabela kwamasosha omzimba okuvame ukubangelwa izindlela zokwelapha ezithile ezifana ne-immunotherapy noma i-CAR-T cell therapy. Kuhilela ukukhululwa ngokweqile kwama-cytokines, okubangela izimpawu ezisukela kumkhuhlane nokukhathala kuya ezinkingeni ezingase zibeke ukuphila engozini njengokulimala kwesitho. Ukuphatha kudinga ukuqapha ngokucophelela kanye namasu okungenelela.

Alysha Mendossa April 29, 2024

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