Abaphenyi ku- I-Memorial Sloan Kettering Cancer Center kanye neMassachusetts Institute of Technology benze uhlelo olusha olunezinyathelo ezintathu olusebenzisa izidakamizwa zenuzi ukukhomba nokuqeda umdlavuza we-colorectal. Abacwaningi bathole isilinganiso sokwelapha esingu-100% kumodeli yegundane futhi abazange babe nemithelela enobuthi ehlobene nokwelashwa . Umbiko wocwaningo ushicilelwe ku-November Journal of Nuclear Medicine.
Kuze kube manje, i-radioimmunotherapy (ukwelashwa okuhlosiwe) kusetshenziswa ama-radionuclide aqondiswe ku-antibody ukwelapha izimila eziqinile inamandla alinganiselwe. “Lolu wucwaningo lwamanoveli. Kuyimisebe yesibili engeyona enobuthi ezicutshini ezijwayelekile zomzimba womuntu ekwelapheni umthamo wesimila. ” Steven m. U-Larson noDkt. Sarah Cheal bachaza, “Impumelelo yemodeli yesimila segundane ivela eqenjini Ikhwalithi eyingqayizivele yama-reagents athuthukisiwe, ngakolunye uhlangothi, isukela ezindleleni zokuzilolonga ezincishisiwe, okuhlanganisa indlela yokwelapha yokwelapha engadluliselwa kalula iziguli. “Le ndlela isebenzisa umuthi owodwa ukuhlola nokwelapha izifo. Umuthi uqale uthole amangqamuzana omdlavuza bese uwabhubhisa ukuze amaseli anempilo angalimali. Ngale ndlela, imiphumela engemihle iyancishiswa futhi izinga lempilo yesiguli liyathuthukiswa.
In this study, glycoprotein A33 (GPA33) was used to recognize A33 tumor antigen. DOTA-pretargeted radioimmunotherapy (PRIT) was tested on a mouse model. For randomly selected test mice, SPECT / CT imaging was used to monitor the treatment response, and the radiation absorbed dose of the tumor was calculated. The tested mice responded well. None of the evaluated mice showed signs of cancer under the microscope, and no significant radiation damage was seen in key organs including bone marrow and kidney.
Izinga lokwelapha elingu-100% kumodeli yegundane liwukuthola okwamukelekayo, okubonisa ukuthi i-anti-GPA33-DOTA-PRIT izoba uhlobo olusebenzayo lwe-radioimmunotherapy ku-GPA33-positive colorectal regimen.
Ngokusho kwe-CDC, umdlavuza we-colorectal ungumdlavuza wesithathu ovame kakhulu othinta amadoda nabesifazane. E-United States, cishe kunamacala amasha ayi-140,000 unyaka ngamunye nokufa kwabantu abangama-50,000.
U-Larson no-Cheal bakholelwa ukuthi uma impumelelo yomtholampilo ifinyelelwa, lokhu kwelashwa kwezikhali zenuzi kunganwetshwa nakwamanye umdlavuza. Uhlelo luklanywe njengohlelo “lokuxhumanisa nokudlala” olungamukela izinhlobonhlobo zamasosha omzimba ngokumelene nama-antigen wesimila somuntu, futhi ngokomgomo lusebenza kuzo zonke izimila eziqinile neziwuketshezi emzimbeni womuntu. Bangeze ngokuthi “umkhakha we-oncology, ikakhulukazi izimila ezihlukahlukene eziqinile ezihlanganisa ikholoni, ibele, amanyikwe, i-melanoma, amaphaphu nommizo, kunesidingo esikhulu sokwelashwa kwezifo ezithuthukile.”
