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I-killer cell immunotherapy ingaphatha umdlavuza osezingeni eliphakeme we-pancreatic

Yabelana ngalokhu okuthunyelwe

Abacwaningi eNyuvesi yaseNew South Wales eSydney kanye neCalifornia Institute of Biomedicine (CALIBR) baye babonisa ukuthi “amangqamuzana abulalayo akhuliswe ngokukhethekile” angasetshenziswa ukwelapha umdlavuza we-pancreatic. Ocwaningweni, ithimba lithole amangqamuzana omdlavuza we-pancreatic ezigulini ezinomdlavuza we-pancreatic osezingeni eliphezulu futhi lawafakela amagundane. Bese uguqula amasosha omzimba esiguli ukuze abone ngokuqondile futhi aqede amangqamuzana omdlavuza, yingakho ebizwa nangokuthi amaseli abulalayo akhuliswe ngokukhethekile noma amaseli e-CAR-T. Ngemva kokuba la maseli e-CAR-T ejovwe emagundeni, akwazi ukuthola wonke amangqamuzana omdlavuza emzimbeni, anamathela kuwo ngokusebenzisa izimpawu ezingaphezulu, bese ebhubhisa amangqamuzana omdlavuza. Umphumela wokwelapha uphawuleka kakhulu, futhi amangqamuzana omdlavuza kumagundane ayanyamalala ngokuphelele, kuhlanganise namangqamuzana omdlavuza asakazekele esibindini nasemaphashini. Lolu cwaningo oluyingqophamlando lusanda kushicilelwa kujenali yezemfundo ephezulu i-Gut.

Abacwaningi abakhombisanga nje kuphela ukusebenza kwe-CAR-T immunotherapy entsha yomdlavuza we-pancreatic. Ngesikhathi esifanayo, kwasungulwa ubuchwepheshe obusha obuzobasiza ukulawula ngokugcwele ukusebenza kwamaseli e-CAR-T. Lisebenzisa lokho okubizwa ngokuthi “amaseli e-CAR-T ashintshayo,” ithimba lasebenzisa lo mqondo omusha kumdlavuza we-pancreatic okokuqala futhi lahlukanisa ukuqashelwa okuhlosiwe komdlavuza kanye nokubulawa kwamangqamuzana omdlavuza okwalandela kwaba yizinqubo ezimbili ezihlukene. UDkt. Alexandra Aicher, umbhali ohambisana naye we-University of New South Wales School of Medicine, uthe ukwelapha ngamaseli e-CAR-T kunamandla kakhulu kodwa kudinga ukuxhashazwa ngokucophelela.

Ithimba manje lithemba ukuletha lolu hlelo lokwelapha oluthembisayo emtholampilo futhi lifuna uxhaso lwezimali ukuze lithuthuke. USolwazi uChris Heeschen, umbhali oholayo we-University of New South Wales School of Medicine, uthe isinyathelo esilandelayo ukuhlanganisa amaseli e-CAR-T nokwelashwa ukuze amaseli e-CAR-T afinyelele kumangqamuzana omdlavuza kalula.

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