Umdlavuza we-Pancreatic
Pancreatic cancer is a malignant tumor of the digestive tract that is highly malignant and difficult to diagnose and treat. About 90% is ductal adenocarcinoma that originates in the ductal epithelium. Its morbidity and mortality rates have increased significantly in recent years. The 5-year survival rate is <1%, which is one of the malignant tumors with the worst prognosis. The early diagnosis rate of umdlavuza pancreatic is not high, the surgical mortality is high, and the cure rate is very low. The incidence of this disease is higher in males than in females , with a male to female ratio of 1.5 to 2: 1. Male patients are much more common than premenopausal women. Postmenopausal women have similar incidences as men.
Ngubani osengozini enkulu yomdlavuza we-pancreatic?
Ngenxa yokuthi umdlavuza wama-pancreas iningi labantu abaneminyaka ephakathi kanye nasebekhulile, bavame ukuba nomlando wokubhema, ngakho-ke kufanele baqaphele ukuyeka ukubhema, baqaphele kakhulu ukulimala kwentuthu kagwayi, futhi banciphise nenani lezindawo ezifana ne-chess. kanye namagumbi amakhadi. Kuye kwaziwa ukuthi ukuphuza ngokweqile kulimaza ama-pancreas, futhi kufanele kuqashelwe ekuvimbeleni ukuphuza, ukwelashwa okufika ngesikhathi kwe-pancreatitis eyingozi futhi engapheli kanye nezifo ze-biliary tract, futhi abantu aba-H. pylori positive nabo kufanele belashwe ngesikhathi.
Thuthukisa imikhuba yokudla enempilo, udle okunamafutha amancane, okunama-kilojoule amaningi, ukudla okuthosiwe nokugosiwe nokudla okufakwe emanzini anosawoti, udle imilenze emine (izinkomo, izimvu, ingulube), udle imilenze emibili (inkukhu, idada, ihansi), Ingenalutho (inhlanzi kanye nezimfanzi) ukudla, udle okusanhlamvu okuhhadlile kakhulu, imifino nezithelo, ikakhulukazi udle i-broccoli, imifino ye-cruciferous (imifino eluhlaza), equkethe izinto ze-isothiocyanate, ingavimbela izinto zamakhemikhali ezibangelwa ukulimala kwe-DNA kanye nezicubu ezahlukahlukene.
Ukulandela ukuvivinya umzimba okusesilinganisweni, imisebenzi ye-aerobic yangaphandle elangeni ingakhuthaza umzimba ukuthi ukhiqize amaprotheni abophayo. Iprotheni ebophayo ine-anti-oxidation kanye nemiphumela yokulwa nesimila.
Ngaphezu kwalokho, itiye eliluhlaza futhi liqukethe izithako ezilwa ne-oxidant futhi kufanele lidliwe njalo.
Amaqembu asengozini enkulu:
1. Uneminyaka engaphezu kwengu-40 ubudala, nokungaphatheki kahle kwesisu okungacacisiwe.
2. Umlando womndeni womdlavuza wepancreatic.
3. Isifo sikashukela esingazelelwe, ikakhulukazi isifo sikashukela se-atypical, ngaphezu kweminyaka engu-60 ubudala, ukungabi nomlando womndeni, akukho ukukhuluphala, futhi ukuthuthukisa ngokushesha ukumelana ne-insulin. I-40% yeziguli ezinomdlavuza we-pancreatic zitholakala ukuthi zinesifo sikashukela.
4. I-pancreatitis engapheli iziguli. Njengamanje, i-pancreatitis engapheli iyisilonda esibalulekile esingaphambi kokuguliswa enanini elincane leziguli, ikakhulukazi i-pancreatitis yomndeni engalapheki kanye ne-pancreatitis engapheli yokubala.
5. I-myxoma ye-Intraductal papillary futhi kuyisilonda esidonsayo.
6. Labo abane umndeni polyposis adenomatous.
7. Labo abathola i-distal gastrectomy ngezilonda ezinobungozi, ikakhulukazi labo abaneminyaka engaphezu kwengu-20 ngemuva kokuhlinzwa.
8. Ukubhema isikhathi eside, ukuphuza kakhulu, nokuchayeka isikhathi eside kumakhemikhali ayingozi. The risk factors for pancreatic cancer are complex, with endogenous (family history, genetic mutation) and exogenous (environment, diet and other factors). A study published in the journal Nature in 2010 pointed out that normal pancreatic ductal epithelial cells gradually evolve into cancer. It takes 9 years from genetic mutation to the formation of a real isisu cell, 8 years from the development of a tumor cell to a cell mass with metastatic ability, and the death from tumor discovery to tumor is less than 2 years. Therefore, the adverse factors that cause cell malignancy should be avoided as much as possible to prevent the occurrence of pancreatic cancer.
1. Ukubhema: Okwamanje ibhekwa njengengozi enkulu yomdlavuza we-pancreatic. Ucwaningo lukhombisile ukuthi isilinganiso sobungozi sokubhema iziguli ezinomdlavuza we-pancreatic kwabangabhemi ngu-1.6-3.1: 1. Ucwaningo lukhombisile ukuthi ama-carcinogens asemacembe kagwayi angadala umdlavuza we-epithelium ye-pancreatic duct.
2. Ukudla okungenampilo: IWorld Cancer Research Foundation neAmerican Cancer Institute zifingqe ubudlelwano phakathi kokudla nomdlavuza wepancreatic. Kukholakala ukuthi ukudla okunothile ngenyama ebomvu (ingulube, inyama yenkomo, iwundlu), amafutha aphezulu namandla aphezulu kungandisa ubungozi bokuba nomdlavuza wepancreatic, futhi ukudla ukudla okunomsoco wemifino nezithelo kungavimbela ama-33% kuya kuma-50% epancreatic umdlavuza Ukugula.
3. Izici zofuzo: Isigameko somdlavuza wepancreatic siphindwe izikhathi ezingama-3-13 kunabantu abanomlando womndeni uma kuqhathaniswa nalabo abangenawo umlando womndeni. Kubikwa ukuthi umuntu oyedwa emndenini unalesi sifo, futhi ingozi yokuba nomdlavuza we-pancreatic phakathi kwamanye amalungu omndeni iphindwe kane kunaleyo yomphakathi jikelele Uma abantu ababili begula, kuzokwenyuka kube yizikhathi eziyi-4, kuthi abantu abathathu bavuke Izikhathi ezingama-2. Abanye abacwaningi bahlangabezane nemindeni eminingi yomdlavuza we-pancreatic womama nendodakazi, ubaba nendodana, izingane zakubo kanye nabazukulu.
4. Izilonda ezinganyangeki zamanyikwe: Iziqephu eziphindaphindayo zepancreatitis engapheli, amatshe e-pancreatic duct noma ama-pancreatitis wokubala anokuthambekela ekubeni nomdlavuza, futhi kungathathwa njengesilonda esingaphambi kwesikhathi. Ukunakwa kufanele kunikezwe ekwelapheni izifo eziyinhloko futhi ukulandelwa kufanele kwenziwe eduze. Ukuqala kuhlobene futhi nezifo zomzimba womuntu uqobo, njengezifo ezingama-pancreatic ezingapheli nezifo zomlomo.
5. Isifo Sikashukela: Ucwaningo luthole ukuthi iziguli ezinesifo sikashukela zinamathuba aphindwe kabili okuba nomdlavuza wepancreatic kunabantu abajwayelekile. Isimo sesifo sikashukela ezigulini ezinomdlavuza we-pancreatic sicishe siphindwe kabili kunesabantu abajwayelekile. Ngakho-ke, iziguli ezingenawo umlando womndeni wesifo sikashukela ngokuzumayo zithola ukuthi kufanele zihlolwe ngokucophelela ukukhipha umdlavuza we-pancreatic.
6. Isimila sepancreatic Benign: Njengezinye izitho, amanyikwe nawo anezicubu eziningi ezinobungozi. Isibonelo: i-serous noma i-mucinous cystadenoma, isimila esiqinile se-pseudopapillary, i-intraductal mucinous papilloma, njll., Nayo engaguqulwa ibe ngumdlavuza we-pancreatic, ikakhulukazi i-mucinous papilloma kanye ne-intraductal mucinous papilloma.
7. Izifo zomlomo: Studies have shown that dental caries and other oral inflammatory diseases can also increase the incidence of pancreatic umdlavuza.
I-8. Abanye: Iziguli ezine-adenomatous polyposis yomndeni, izilonda ezinobungozi ezenziwa yi-distal gastrectomy, isifo se-biliary tract, ukuvuselelwa kwe-gallbladder, kanye ne-Helicobacter pylori positive nakho kuzokwandisa ingozi yomdlavuza we-pancreatic.
