In the United States, more than 70,000 people are diagnosed with non-Hodgkin’s lymphoma each year, which is caused by excessive proliferation of immune cells in the body’s lymph nodes. The most common is diffuse large B-cell lymphoma (DLBCL), which accounts for about 1/3 of lymphomas, and about half of these tumors are resistant to chemotherapy and immunotherapy. Lenfoma limfa to'qimasidan kelib chiqqandan so'ng, hujayra ko'payishi to'qimalarning umumiy tuzilishini yorilishiga olib keladi va hujayralar suyuqlik oqimi kabi mexanik kuchlarga ta'sir qiladi.
Tadqiqotchilar bu suyuqlik kuchlarining o'simtaga chidamliligi bilan qanday bog'liqligini o'rganishdi va limfa tomirlari va ba'zi limfa tugunlaridagi naqshlarga o'xshash inson limfomasini suyuqlik oqimiga ta'sir qiladigan "limfoma mikroreaktor" qurilmasini ishlab chiqdilar.
Jamoaning yon oqim mikroreaktori limfa tomirlari va limfa tugunlari qismlarini simulyatsiya qilish uchun suyuqlik oqimini sekinlashtiradigan tor qarshilik kanali orqali madaniyat muhiti (suyuqlik) kamerasiga ulangan hujayra madaniyati kamerasini o'z ichiga oladi. DLCBL lenfomasining turli subpopulyatsiyalarini sinovdan o'tkazishda tadqiqot guruhi hujayra yuzasida topilgan B hujayra retseptorlari molekulalarining mutatsiyalariga ko'ra tasniflangan ba'zi kichik tiplar suyuqlik kuchlariga boshqacha javob berishini aniqladi. Jamoa suyuqlik quvvati integrin-adezin va B hujayra retseptorlarining ifoda darajasini tartibga solishini aniqladi. Integrin va B hujayra retseptorlari signallari o'rtasida o'zaro shovqin mavjud bo'lib, bu ba'zi o'smalarning qarshiligini tushuntirishga yordam beradi.
What is remarkable is that the same tumor subtype responds differently to mechanical forces. If we can understand the role of biophysical stimulation, we can know why some lymphomas are sensitive to treatment, while others are refractory, then we will be able to treat more patients. It is important to understand the factors that regulate B-cell receptor signaling because this pathway is a key target for new therapeutic drugs, and several of them are in clinical trials. Batafsil ma'lumot uchun qo'ng'iroq qiling Saraton kasalligi.
