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Tips to reduce the risk of cancer

To reduce the risk of cancer, adopt a healthy lifestyle. Start by maintaining a balanced diet rich in fruits, vegetables, and whole grains while limiting processed foods and sugary drinks. Stay physically active and maintain a healthy weight. Avoid smoking and limit alcohol consumption. Protect yourself from the sun's harmful UV rays, and get vaccinated against viruses like HPV and Hepatitis B. Regular screenings and early detection are also crucial for prevention.

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Tips to reduce the risk of cancer

Although the exact cause of cancer is still unknown and a lot of research has been conducted to unearth this area, the lifestyle choices one makes do determine the consequences to a great extent. Here are some very simple lifestyle modifications that will make a big difference.

  • Say no to tobacco. Smoking and the use of tobacco have been linked to many types of cancer. Even if one does not use tobacco, its exposure can also result in cancer. One of the best decisions one can make is to avoid tobacco or smoking. This reduces the chances of catching cancer to a large extent.
  • Eat plenty of fruits and vegetables and have healthy food habits.
  • Avoid obesity.
  • Use alcohol in moderation.
  • Limited processed meat.
  • Be physically active and maintain a healthy body weight.
  • Protect yourself from the sun.
  • Get yourself immunized against Hepatitis B and HPV.
  • Practice safe sex.
  • Don’t share needles.
  • Get yourself medically checked every year after the age of 45.

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Targeting FGFR4 and CD276 with CAR T-cells demonstrates a strong antitumor impact against children rhabdomyosarcoma
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Targeting FGFR4 and CD276 with CAR T-cells demonstrates a strong antitumor impact against children rhabdomyosarcoma

Chimeric antigen receptor (CAR) T-cells that specifically target Fibroblast Growth Factor Receptor 4 (FGFR4), a surface tyrosine receptor that is extensively expressed in rhabdomyosarcoma (RMS), are now undergoing clinical research. However, the effectiveness of these CAR T-cells may be hindered by tumor heterogeneity and inadequate activation. In this study, we present a method to enhance the co-stimulatory and targeting characteristics of a FGFR4 CAR through an optimization process. We substituted the hinge and transmembrane domain of CD8 as well as the 4-1BB co-stimulatory domain with the corresponding domains of CD28. The CARs produced exhibit heightened anti-tumor efficacy in multiple RMS xenograft models, with the exception of the RMS559 cell line, which is known for its aggressive nature.

Susan Hau July 24, 2024

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