In the largest genome-wide pancreatic cancer study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute and collaborators in more than 80 other institutions worldwide have discovered mutations in five new regions of the human genome This may increase the risk of pancreatic cancer.
The discovery was published in Nature Communications on February 8, and scientists analyzed more than 11.3 million mutations in 21,536 people. These new discoveries have prompted another step in grasping the genetic changes associated with pancreatic cancer risk factors, which can better understand the pathogenesis of pancreatic cancer and guide the research of more targeted treatment methods and early detection and screening methods. Newly identified genetic variants on human chromosomes 1 (position 1p36.33), 7 (position 7p12), 8 (position 8q21.11), 17 (position 17q12), and 18 (position 18q21.32) increase pancreatic cancer risk . The presence of each copy in these genomes increases the risk of pancreatic cancer by 15-25%.
At the individual level, there is a mutation that does not completely predict cancer, because they are only associated with a modest change in risk, but when they are combined, they help to more fully understand the pathogenesis of pancreatic cancer. The researchers will continue to delve into the genetic characteristics of pancreatic cancer, and there are many genetic factors that we do not know about the risk of pancreatic cancer.
Understanding the genetic mutation mechanism of pancreatic cancer can better develop targeted drugs, which will set off a wave of pancreatic cancer treatment. There are many targeted drugs on the market for other cancers. For different types of mutant genes, targeted drugs are used to reduce side effects and improve efficacy. Therefore, it is recommended that cancer patients must pay attention to the benefit space of targeted therapy and conduct genetic testing before medication.
The large authoritative companies that can choose to carry out genetic testing for cancer are American Kerrys, American Foundation, and the domestic ones have Pansheng, Shihe Gene. The Global Oncologist Network can assist patients with genetic testing throughout the process. Patients can consult the Global Oncologist Network for consultation .
Reference : https://medicalxpress.com/news/2018-02-genetic-linked-pancreatic-cancer.html
