The combination of two monoclonal antibodies for the treatment of lymphoma is 50% effective

Share This Post

According to a multi-center clinical trial led by researchers at the Stanford University School of Medicine, a new type of immunotherapy seems to be safe for patients with blood cancer called non-Hodgkin’s lymphoma.

The therapy combines experimental antibodies developed by researchers at Stanford University and commercially available anti-cancer antibodies to rituximab. It referred Hu5F9-G4 experimental protein antibody blockade of CD47 , of CD47 suppressed immune attack against cancer cells. The combination of two antibodies is used to treat people with two types of non-Hodgkin’s lymphoma: diffuse large B- cell lymphoma and follicular lymphoma.

In 2010 , researchers led by Irving Weissman , MD, director of the Stanford Stem Cell Biology and Regenerative Medicine Institute, showed that almost all cancer cells are covered with a protein called CD47 , which can play a ” do n’t eat me ” Signal to macrophages.

Weissman and colleagues later developed an antibody called Hu5F9-G4 that blocks the CD47 protein and encourages macrophages to engulf cancer cells. Rituximab is an antibody that has been shown to amplify the positive ” eat me ” signal. The combination of rituximab and Hu5F-G4 has previously been shown to be effective against human cancer in animal models, but this is the first published result of clinical trials of the therapy in humans.

Of the 22 patients participating in the trial , 11 patients had significantly reduced clinical cancer, and 8 patients had eliminated all signs of cancer. The other three patients in the trial did not respond to treatment and died due to disease progression. The researchers observed that the participants had only minor side effects.

Dr. Saul A. Rosenberg , a lymphoma professor , said that such a potential new immunotherapy is very exciting. This is the first time that an antibody that can activate macrophages to fight cancer is used, and it seems to be safe for use in humans.

https://medicalxpress.com/news/2018-10-anti-cd47-cancer-therapy-safe-small.html

Subscribe To Our Newsletter

Get updates and never miss a blog from Cancerfax

More To Explore

Ivosidenib is approved by FDA for myelodysplastic syndromes
MDS

Ivosidenib is approved by FDA for myelodysplastic syndromes

The Food and Drug Administration approved ivosidenib (Tibsovo, Servier Pharmaceuticals LLC) for adult patients with relapsed or refractory myelodysplastic syndromes (MDS) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation, as detected by an FDA-approved test.

Need help? Our team is ready to assist you.

We wish a speedy recovery of your dear and near one.

درمان سرطان در تركيه
Start chat
Need help with cancer treatment?
Scan the code
Hello,
Welcome to CancerFax !

CancerFax is the most trusted international patient facilitator working with top cancer hospital's in the world like MD Anderson, Dana Farber, Asan, NCC Japan, Sheba, Beijing Cancer Institute and Apollo to bring you best of therapies and drugs.

Let us know what services would you like to avail?

1) Cancer treatment in the USA, Japan, Israel, India, Korea or Singapore?
2) CAR T-Cell therapy treatment
3) Cancer vaccine
4) Online video consultation
5) Proton therapy