Nonalcoholic fatty liver disease (NAFLD) is a very common disease. To better understand the link between NAFLD and hepatocellular carcinoma (HCC) risk, researchers at Baylor College of Medicine conducted a large Retrospective study published in “Gastroenterology”.
In this study, the research team studied groups from the Veterans Health Administration and followed up for about 11 years. The study included 296,707 patients known to have NAFLD and 296,707 patients without NAFLD. Among NAFLD patients, 490 have HCC, and their risk of developing HCC is much higher than those without NAFLD.
Dr. Fasiha Kanwal, professor and chief of medicine, and colleagues found that NAFLD patients with liver cirrhosis have the highest incidence of HCC each year. The risk of HCC increases with age, and the elderly Spanish with liver cirrhosis is HCC High-risk groups.
“This study provides valuable and powerful information on which of the millions of NAFLD patients are at risk for HCC. This information is an important step forward in our understanding of the disease. For researchers, clinical Doctors and patients have important reference value, ” said Dr. Hashem EI-Serag, professor of gastroenterology at Baylor Medicine and senior author of the paper . Moreover, the results of this study also provide guidance for monitoring and risk adjustment for people at increased risk of liver cancer, such as patients with cirrhosis or diabetes.
Susan Hau is a distinguished researcher in the field of cancer cell therapy, with a particular focus on T cell-based approaches and cancer vaccines. Her work spans several innovative treatment modalities, including CAR T-cell therapy, TIL (Tumor-Infiltrating Lymphocyte) therapy, and NK (Natural Killer) cell therapy.
Hau's expertise lies in cancer cell biology, where she has made significant contributions to understanding the complex interactions between immune cells and tumors.
Her research aims to enhance the efficacy of immunotherapies by manipulating the tumor microenvironment and exploring novel ways to activate and direct immune responses against cancer cells.
Throughout her career, Hau has collaborated with leading professors and researchers in the field of cancer treatment, both in the United States and China.
These international experiences have broadened her perspective and contributed to her innovative approach to cancer therapy development.
Hau's work is particularly focused on addressing the challenges of treating advanced and metastatic cancers. She has been involved in clinical trials evaluating the safety and efficacy of various immunotherapy approaches, including the promising Gamma Delta T cell therapy.
