Mayo clinic trials triple negative breast cancer vaccine

Share This Post

Mayo Clinic

Researchers at the Mayo Clinic Florida campus received a five-year federal grant totaling $ 13 million to test vaccines designed to prevent the recurrence of triple-negative breast cancer. Triple-negative breast cancer is a type of highly malignant breast cancer, and there is currently no targeted treatment.

280 patients will participate in this clinical trial, which began in early 2016.

The funding is a breakthrough award from the U.S. Department of Defense’s Breast Cancer Research Project and will be used to fund a nationwide phase II clinical trial to test the folate receptor alpha vaccine to prevent this highly malignant tumor from recurring after treatment.

A phase I clinical trial involving 22 patients previously led by Keith Knutson, PhD in immunology, found the vaccine safe. It does not induce autoimmunity.

The vaccine was designed by Dr. Knutson and was initially tested by the Mayo Clinic Rochester campus researchers for safety testing and the ability to stimulate the immune system.

It takes advantage of the characteristics of triple negative breast cancer that require folic acid intake. Dr. Knutson said that because of this need, these tumors synthesize a large amount of folate receptor alpha, which is used to latch folic acid into the tumor’s microenvironment.

There is evidence that some patients can naturally develop an immune response to these receptors. But cancer is too strong for this weak immune response,” Dr. Knutson said.

The purpose of the vaccine is to promote the immune system to respond quickly to cancer cell receptors during the early stages of tumor recurrence.

He said, “We believe that the vaccine will provide a stronger and lasting immune response to the recipient, which will in turn improve the body’s ability to obtain folic acid by cutting off the tumor and directly or indirectly kill the tumor.”

To apply for breast cancer clinical trials call +91 96 1588 1588 or write to cancerfax@gmail.com.
Website |  + posts

Susan Hau is a distinguished researcher in the field of cancer cell therapy, with a particular focus on T cell-based approaches and cancer vaccines. Her work spans several innovative treatment modalities, including CAR T-cell therapy, TIL (Tumor-Infiltrating Lymphocyte) therapy, and NK (Natural Killer) cell therapy.

Hau's expertise lies in cancer cell biology, where she has made significant contributions to understanding the complex interactions between immune cells and tumors.

Her research aims to enhance the efficacy of immunotherapies by manipulating the tumor microenvironment and exploring novel ways to activate and direct immune responses against cancer cells.

Throughout her career, Hau has collaborated with leading professors and researchers in the field of cancer treatment, both in the United States and China.

These international experiences have broadened her perspective and contributed to her innovative approach to cancer therapy development.

Hau's work is particularly focused on addressing the challenges of treating advanced and metastatic cancers. She has been involved in clinical trials evaluating the safety and efficacy of various immunotherapy approaches, including the promising Gamma Delta T cell therapy.

Subscribe To Our Newsletter

Get updates and never miss a blog from Cancerfax

More To Explore

Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment
CAR T-Cell therapy

Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment

CAR T cell therapy has transformed cancer treatment, especially in hematological malignancies. Treatment of solid tumors remains challenging due to their immunosuppressive tumor microenvironment. Combination with chemotherapy, immune checkpoint inhibitors, oncolytic viruses, and improved genetic engineering holds promise. Multimodal approaches enhance immune cell infiltration and persistence, raising efficacy. Evolving personalized methods will be instrumental in overcoming solid tumor resistance and improving patient outcomes.

How to prevent infections in patients receiving CD19-targeted chimeric antigen receptor T cells for B-cell malignancies
CAR T-Cell therapy

How to prevent infections in patients receiving CD19-targeted chimeric antigen receptor T cells for B-cell malignancies?

CAR T-cell therapy revolutionized cancer therapy, offering incredible success in the management of B-cell malignancies, but it is associated with severe infection risks secondary to immunosuppression. Preventive measures are pre-infusion screening, vaccination, and antimicrobial prophylaxis. Post-infusion, close surveillance for infection and cytokine release syndrome management are key. Long-term care includes the treatment of hypogammaglobulinemia, revaccination, and patient education. The approach ensures improved outcomes and reduces infection-related complications in patients receiving CD19-targeted CAR T-cell therapy.

Need help? Our team is ready to assist you.

We wish a speedy recovery of your dear and near one.

Start chat
We Are Online! Chat With Us!
Scan the code
Hello,

CancerFax is the most trusted online platform dedicated to connecting individuals facing advanced-stage cancer with groundbreaking cell therapies.

Send your medical reports and get a free analysis.

🌟 Join us in the fight against cancer! 🌟

Привет,

CancerFax — это самая надежная онлайн-платформа, призванная предоставить людям, столкнувшимся с раком на поздних стадиях, доступ к революционным клеточным методам лечения.

Отправьте свои медицинские заключения и получите бесплатный анализ.

🌟 Присоединяйтесь к нам в борьбе с раком! 🌟