Drug toxicity testing for liver cancer patients

Share This Post

Poietis worked with pharmaceutical company Servier to develop a 4D bioprinted liver model that can better predict the liver toxicity of drugs. 

Hepatotoxicity testing is one of the key tests conducted during preclinical trials using study drugs. Bruno Brisson, co-founder of Poietis, said, “The role of the liver is to degrade substances that are toxic to the body into non-toxic products, but sometimes excessive toxicity can cause important liver lesions.” Animal models of human hepatocytes and cell culture are usually used To predict toxicity, but because they cannot fully replicate the processes that occur in the liver of a real human, their accuracy is limited.

Using Poietis’ bioprinting technology, you can better perform tests to predict liver toxicity. Using the company’s laser-assisted bioprinting technology, the liver model contains different types of human liver cells and immune cells, which can be distributed in three dimensions with high precision. Brisson further explained, “Most of the in vitro liver models used for drug analysis are generated using two-dimensional monolayer cell tissue, but this new three-dimensional model better simulates the complex liver multicellular tissue structure. Drug toxicity testing is of great significance. The model will be validated by testing a group of compounds that can or cannot induce liver toxicity. Brisson is expected to complete it within 18 months.

 

Subscribe To Our Newsletter

Get updates and never miss a blog from Cancerfax

More To Explore

LungVax lung cancer vaccine
Lung cancer

LungVax: Lung cancer vaccine

LungVax is an innovative lung cancer vaccine designed to stimulate the immune system to target and destroy cancer cells. It is engineered to enhance the body’s natural defense mechanisms against tumor growth, offering a novel approach to lung cancer treatment. LungVax aims to prevent recurrence in high-risk patients and improve survival rates, marking a promising development in immunotherapy for one of the deadliest forms of cancer.

Need help? Our team is ready to assist you.

We wish a speedy recovery of your dear and near one.

Start chat
We Are Online! Chat With Us!
Scan the code
Hello,

Welcome to CancerFax !

CancerFax is a pioneering platform dedicated to connecting individuals facing advanced-stage cancer with groundbreaking cell therapies like CAR T-Cell therapy, Gene therapy, TIL therapy, and clinical trials worldwide.

Let us know what we can do for you.

1) CAR T-Cell therapy
2) Gene therapy
3) Gamma-Delta T Cell therapy
4) TIL therapy
5) NK Cell therapy