CAR T Cell Therapy for Blood Cancers
Introduction Blood cancers, also known as hematologic malignancies, include leukemia, lymphoma, and multiple myeloma. These cancers have their origins in either bone marrow or the lymphatic system and are characterized by..
CAR T Cell Therapy for Relapsed and Refractory Cancers
Introduction Relapsed and refractory cancers are highly challenging for treatment due to their general resistance to most standard therapies. These cases represent an area of enormous unmet need in oncology. Recently, one of the ..
CAR T Cell Therapy for Pediatric Cancer
Introduction Although relatively rare, pediatric malignancy is one of the leading causes of mortality in children worldwide. Even though traditional therapies like chemotherapy, radiation, and surgery have improved survival signi..
CAR T Cell Therapy for Solid Tumors
Introduction Although CAR T cell therapy has been highly effective in hematologic malignancies, it is an altogether different ballgame in solid tumors. Numerous peculiar difficulties make it difficult to determine whether CAR T c..
CAR T-Cell therapy for lymphoma
Introduction CAR T cell therapy has been a game-changer in the treatment of certain lymphomas, more so in patients relapsing or refractory to conventional therapies. This has been quite successful in targeting cancer cells within..
CAR T-Cell therapy for leukemia
Introduction CAR T cell therapy is the breakthrough treatment against various kinds of leukemias, particularly B-cell ALL. In this treatment, genetically modified T cells are specifically designed to target antigens on cancer cel..
Types of cancer treated with CAR T-Cell therapy
Introduction CAR T cell therapy has really taken off in harnessing the immune system to specifically destroy cancerous cells. After showing tremendous success at first in the treatment of hematologic malignancies, CAR T cell ther..
Complete mechanism of CAR T Cell therapy explained
Introduction CAR T cell therapy is a nascent cancer treatment that targets and eliminates cancerous cells by using the body's immune system. Gene modification is done for the expression of chimeric antigen receptors on T cells, w..
Gamma delta T cells: Latest option in cancer treatment
Two types of T-cells There exist two distinct categories of T cells: αβ T cells and γδ T cells. The previous statement describes a T-cell receptor (TCR) that consists of a heterodimer composed of α and β chains. The latter ..
Targeting FGFR4 and CD276 with CAR T-cells demonstrates a strong antitumor impact against children rhabdomyosarcoma
CAR T-Cell treatment Chimeric Antigen Receptor (CAR) T-cell treatments, which target antigens that are unique to cancer, have shown amazing results in curing leukemia and lymphoma that has not responded to other treatments or has..