Ucwaningo oluvela eNyuvesi yaseCincinnati School of Medicine ku-Annual Cancer Symposium on Surgical Oncology e-Chicago ngoMashi 24, 2018 lubonise ukuthi i-adjuvant noma ukwelashwa okwengeziwe ngemva kokuhlinzwa kabusha kwezinhlobo ezingavamile zamathumba amathumbu akuthuthukisi izinga lokusinda kweziguli. Lokhu okutholakele kunikeza imininingwane ejulile ngezinketho zokwelapha zalezi zinhlobo zeziguli ezinomdlavuza, futhi kungase kungasadingi ukwelashwa okunqunyiwe kwe-adjuvant, ukugcina izinga lempilo, nokonga imali.
Kulolu cwaningo, abacwaningi basebenzise idatha yesimila yesigaba I kuya ku-III iziguli ezine-ampula esuswe ngokuhlinzwa kusukela ngo-1998 kuya ku-2006 (iziguli ezingu-5,298) ku-National Cancer Database ye-American College of Surgeons ukuqhathanisa ukuhlinzwa kuphela (3,785), ukuhlinzwa kanye Neziguli. nge-chemotherapy eyengeziwe (316) nalabo abahlinzwa kanye nokwelashwa ngamakhemikhali okwengeziwe kanye ne-radiotherapy (1,197) bahlaziywa ukuze baphile.
29% (1,513) of patients who underwent surgical resection of ampullary izicubu received adjuvant therapy. Adjuvant therapy is more commonly used in patients with stage III, lymph node tumors, and positive surgical margins. However, there was no significant difference in stage-specific survival rates among patients with stage I, II, or III receiving any treatment. Similarly, patients with lymph node tumors and positive surgical margins received no adjuvant survival benefit. This national analysis showed that even for patients with aggressive disease, the adjuvant treatment of surgically removed ampullary tumors did not show any survival benefit.
Ngakho-ke, kungakhathaliseki ukuthi hlobo luni lomdlavuza, noma yimuphi umdlavuza oye wathuthuka, kuyadingeka ukuhlola ama-subtypes omdlavuza kanye nokwehluka kwawo ezingeni lamaselula. Kuphela ngokuhlolwa kofuzo lapho singakwazi khona ukunquma izinguquko ezingeni lamangqamuzana eziguli futhi siqondise ukwelashwa okunembe kakhudlwana. Ukuhlaziywa kwe-atlas ye-multi-platform yase-United States (inkampani egunyaziwe yezidakamizwa eziqondisa umdlavuza e-United States) ayikwazi nje ukuhlaziya izakhi zofuzo zomshayeli womdlavuza ezingeni lofuzo, kodwa futhi ihlanganise i-RNA nokutholwa kwamaprotheni ukuze ihlaziye izindlela zamangqamuzana ezinamazinga amaningi, ngokuphelele. hlola izici zesimila, futhi uqondise ngokuphelele imithi yezimpawu. Ulwazi oluningiliziwe lungaboniswa ku-Global Oncologist Network.
