Kukhona impumelelo yakamuva kumdlavuza wamaphaphu wamangqamuzana amancane. Uhlobo lwe ukugonywa engakwazi ukwelapha umdlavuza wamaphaphu wamangqamuzana ongewona omncane (i-NSCLC) uhlangabezane nokuvunyelwa kwemitholampilo kwesigaba 3 futhi kunomthelela omkhulu we-therapeudic ezifweni ezingezona ezincane zamaphaphu. Kuyatholakala manje emazweni ambalwa kakhulu.
As an anti-idiotype monoclonal antibody, the vaccine enables lung cancer patients to respond strongly to specific glycosylated gangliosides (NeuGcGM3) in cancer cells. Compared with the best supportive care, lung umuthi wokugomela umdlavuza ingathuthukisa izinga lokusinda leziguli ezinesiteji esiphinde sabuyela emuva futhi esithuthukile (isigaba IIIB/IV) NSCLC.
Rather than numerous warm blooded creatures, including gorillas, we can’t recognize the nearness of NeuGcGM3 gangliosides in typical human tissues and liquids. Be that as it may, NeuGcGM3 gangliosides are profoundly communicated in certain human malignant growth cells. In non-little cell lung malignancy tests, gangliosides were identified in over 90% of non-little cell lung tumors. Thusly, NeuGcGM3 ganglioside can be utilized as a ground-breaking objective for lung malignant growth antibodies.
Ngemuva kohlaka olungacabangi ukukhiqiza amasosha omzimba acacile alwa ne- i-antigen, ingakha amasosha omzimba alwa nengqayizivele ye-antigen eyinhloko, engalawula uhlaka olungazweli ngaphakathi. Ngemuva kokugonyelwa lokhu kukhula okuyingozi kwamaphaphu ukugonywa, it can advance the generation of antibodies against this antigen, assigned Ab1. These Ab1 antibodies are fit for delivering a progression of hostile to idiotypic antibodies, assigned Ab2. The idiotypes of these exceptional antibodies are fused into the antigen-restricting site of Ab1, with the goal that these extraordinary antibodies produce a particular resistant reaction to regular antigens. Hence, vaccination with Ab2 immunizer can advance the creation of Ab3 (hostile to against idiotype neutralizer), and this Ab3 counter acting agent can perceive the first antigen perceived by Ab1. Some Ab2 antibodies of this sort invigorate the safe framework to actuate defensive resistance against isisu ama-antigen.
Kuboniswe emtholampilo ukuthi isifo samaphaphu ukugonywa likhuthazelele kakhulu futhi lingcono ukwenziwa kahle. Izimpawu eziningi eziyisisekelo zenzeka endaweni yangakini (isiza sokumnika) futhi ngokuvamile zimnene futhi zibude obufushane. Akunandaba noma ngabe i-antibody inikezwa iziguli ngemuva kokuthi isimo sazo sesihlakazekile, ukukhuthazela kwabo okujwayelekile sekuthuthukile.
Njengamanje, lolu hlobo lokugoma okukhulayo kwamaphaphu alukhuthazwa eNdiya.
