Scientists at the University of California, San Francisco have discovered a common genetic driver of aggressive meningioma, which can help clinicians detect this dangerous cancer earlier and find new treatments for these difficult-to-treat tumors. A research team led by Dr. David Raleigh found that increased gene activity called FOXM1 seems to be responsible for the aggressive growth, and these tumors frequently relapse.
To investigate the factors that may lead to aggressive meningioma, Raleigh’s team collected 280 human meningioma samples from 1990 to 2015. Using a range of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these o'smalari and patients’ clinical outcomes. Finally, a gene called FOXM1 was found to be the core of the growth of invasive meningioma, and also an indicator of the subsequent adverse clinical outcomes, including death.
Tadqiqotchilar, shuningdek, agressiv meningiomalarning tarqalishi va hujayralararo signalizatsiya yo'llarining faollashishi o'rtasida Wnt deb nomlangan yangi aloqani kashf etdilar, bu odatda embrion rivojlanishi va to'qima hosil bo'lishida rol o'ynaydi. FOXM1 tomonidan ishlab chiqarilgan oqsil Wnt yo'li bo'ylab signallarni uzatishi mumkinligini hisobga olsak, yangi ma'lumotlar FOXM1 va Wnt yo'llarining kooperativ ishi meningiomalarning keyingi tarqalishiga olib kelishi mumkinligini ko'rsatadi. Gipermetilatsiya agressiv meningioma hosil bo'lishining dastlabki qo'zg'atuvchisi bo'lishi mumkin.
Raleighning aytishicha, kelajakda olib boriladigan ishlar meningioma o'sishini ta'minlash uchun qaysi FOXM1 genlarini faollashtirishi va ushbu maqsadlarni klinik davolash usullari bilan bloklashi kerak. Ushbu yo'lda miya shishi patogenezini iloji boricha tezroq to'xtatish va saraton bilan kasallangan bemorlarning ko'pchiligiga foyda keltiradigan dorilar bo'ladi degan umiddamiz.
