Pensilvaniya universiteti tibbiyot fakulteti qoshidagi Abramson saraton markazining (ACC) tadqiqot guruhi o'simtaning issiq yoki sovuq ekanligini saraton hujayralarining o'zida joylashgan ma'lumotlarga ko'ra aniqlashini aniqladi. “Hot” tumors are often considered more sensitive to immunotherapy. In a new study published this week in Immunity, the researchers explored the role of “tumor heterogeneity”, namely the ability of tumor cells to move, replicate, metastasize and respond to treatment. These new findings can help oncologists more accurately tailor the unique shish composition of patients.
Pensilvaniya universiteti Perelman tibbiyot maktabining gastroenterologiya va hujayra va rivojlanish biologiyasi professori Ben Stangerning aytishicha, T hujayralarining o'smalarga jalb qilish darajasi o'simtaga xos genlar bilan tartibga solinadi. Shishlar o'sishi uchun ular immunitet tizimining hujumlaridan qochishlari kerak. Ikkita yo'l bor: sovuq o'smalarga yoki T hujayralarini yo'q qiladigan issiq o'smalarga aylanish, o'simta hujayralarini bemorning immunitet tizimiga zarar etkazishdan samarali himoya qilish.
In this study, researchers found that whether a tumor is hot or cold determines whether it will respond to immunoterapiya. Cold tumor cells produce a compound called CXCL1, which can instruct bone marrow cells to enter the tumor, keep T cells away from the tumor, and ultimately make the immunotherapy insensitive. In contrast, knocking out CXCL1 in cold tumors promotes T cell infiltration and sensitivity to immunotherapy.
Jamoa me'da osti bezi o'smalarining xususiyatlarini, shu jumladan ular tarkibidagi immunitet hujayralarining turlarini taqlid qiluvchi bir qator hujayra chiziqlarini yaratdi. Kelajakda bu o'simta hujayralari liniyalari o'simtaning turli xil heterojenlik holatlariga ega bo'lgan bemorlarning o'ziga xos kichik turlari uchun davolashni yanada aniqlash va optimallashtirishga yordam beradi.
