kanker Pancreatic
Pancreatic cancer is a malignant tumor of the digestive tract that is highly malignant and difficult to diagnose and treat. About 90% is ductal adenocarcinoma that originates in the ductal epithelium. Its morbidity and mortality rates have increased significantly in recent years. The 5-year survival rate is <1%, which is one of the malignant tumors with the worst prognosis. The early diagnosis rate of kanker pancreatic is not high, the surgical mortality is high, and the cure rate is very low. The incidence of this disease is higher in males than in females , with a male to female ratio of 1.5 to 2: 1. Male patients are much more common than premenopausal women. Postmenopausal women have similar incidences as men.
Saha anu résiko tinggi pikeun kanker pankreas?
Kusabab kanker pankréas lolobana jalma tengah-yuswa jeung manula, maranéhanana mindeng boga sajarah roko, jadi maranéhanana kudu merhatikeun kaluar roko, merhatikeun husus ka ngarugikeun tina haseup kadua leungeun, jeung ngurangan jumlah tempat saperti catur. jeung kamar kartu. Geus dipikanyaho yén nginum beurat ogé ngaruksak pankréas, sarta perhatian kudu dibikeun ka restraining nginum, perlakuan timely of pankreatitis akut jeung kronis sarta panyakit saluran biliary, sarta H. pylori jalma positif ogé kudu dirawat dina waktu.
Ngembangkeun kabiasaan tuang séhat, tuang kirang gajih tinggi, kalori tinggi, asep sareng asak goreng sareng tuang acar, tuang opat suku (sapi, domba, babi), tuang dua suku (hayam, bebek, soang)), Legless (lauk sareng udang) tuangeun, tuang langkung bijil kasar, sayuran sareng buah-buahan, utamina tuang brokoli, sayuran salib (sayuran hejo), anu ngandung zat isothiocyanate, tiasa nyegah zat kimia anu nyababkeun Tatu DNA sareng sagala rupa tumor.
Taat kana latihan fisik sedeng, kagiatan aérobik outdoor di panonpoé bisa ngamajukeun awak pikeun ngahasilkeun protéin mengikat. Protéin beungkeutan gaduh pangaruh anti-oksidasi sareng anti-tumor.
Salaku tambahan, téh héjo ogé ngandung bahan antioksidan sareng kedah dikonsumsi sacara rutin.
Grup anu résiko tinggi:
1. Umur langkung ti 40 taun, kalayan ngarareunah beuteung luhur henteu spésipik.
2. Sejarah kulawarga kanker pankreas.
3. Diabetes ngadadak, utamana diabetes atypical, heubeul leuwih 60 taun, kurangna sajarah kulawarga, euweuh obesitas, sarta gancang ngamekarkeun résistansi insulin. 40% pasien kanker pankréas didiagnosis kalayan diabetes.
4. Pankreatitis kronis pasién. Ayeuna, pancreatitis kronis mangrupikeun lesi anu precancerous penting dina sajumlah leutik pasien, khususna pancreatitis kulawarga kronis sareng pancreatitis palsu kronis.
5. Mixoma papillary intraductal ogé lesion precancerous.
6. Anu gaduh polyposis adenomatous kulawarga.
7. Sing saha anu ngalaman gastrectomy distal pikeun lesi entéh, utamina anu langkung ti 20 taun saatos dioperasi.
8. Roko jangka panjang, nginum beurat, sareng kakeunaan jangka panjang bahan kimia ngabahayakeun. The risk factors for pancreatic cancer are complex, with endogenous (family history, genetic mutation) and exogenous (environment, diet and other factors). A study published in the journal Nature in 2010 pointed out that normal pancreatic ductal epithelial cells gradually evolve into cancer. It takes 9 years from genetic mutation to the formation of a real tumor cell, 8 years from the development of a tumor cell to a cell mass with metastatic ability, and the death from tumor discovery to tumor is less than 2 years. Therefore, the adverse factors that cause cell malignancy should be avoided as much as possible to prevent the occurrence of pancreatic cancer.
1. ngaroko: Ayeuna diakuan salaku faktor résiko tinggi pikeun kanker pankreas. Panilitian parantos nunjukkeun yén babandingan résiko roko pasién kanker pankreas ka anu sanés perokok nyaéta 1.6-3.1: 1. Panilitian parantos nunjukkeun yén karsinogen dina daun bako tiasa nyababkeun kanker épitél saluran pancreatic.
2. Diét henteu séhat: Yayasan Panilitian Kanker Dunya sareng American Cancer Institute nyimpulkeun hubungan antara diét sareng kanker pankreas. Dipercaya yén pangan beunghar daging beureum (babi, sapi, domba), gajih tinggi sareng énergi tinggi tiasa ningkatkeun résiko kanker pankreas, sareng asupan diet anu beunghar sayuran sareng buah tiasa nyegah 33% dugi 50% pankreas kanker Morbidity.
3. Faktor genetik: Kajadian kanker pankreas nyaéta 3-13 kali tibatan jalma-jalma anu gaduh riwayat kulawarga dibandingkeun sareng anu teu gaduh riwayat kulawarga. Dilaporkeun yén hiji jalma dina kulawarga ngagaduhan panyakit, sareng résiko kanker pankreas diantara anggota kulawarga anu sanés nyaéta 4 kali tina populasi umum Upami 2 jalmi gering, éta bakal naék janten 12 kali, sareng 3 urang tiasa dugi ka 40 kali. Sababaraha panaliti parantos mendakan sababaraha kulawarga kanker pankreas indung sareng putri, bapa sareng putra, dulur, sareng incu.
4. Lesi kronis tina pankréas: Épisode anu teras-terasan tina pankreatitis kronis, batu saluran pankreas atanapi pancreatitis ngitung gaduh kacenderungan janten kanker, sareng tiasa dianggap salaku lesion precancerous. Perhatian kedah dibayar pikeun pengobatan panyakit primér sareng tindak lanjut kedah dilaksanakeun sacara raket. Serangan ogé aya hubunganana sareng panyakit awak manusa nyalira, sapertos panyakit pankreas kronis sareng panyakit lisan.
5. Diabétes: Panilitian mendakan yén pasién diabetik dua kali langkung dipikaresep ngagaduhan kanker pankreas salaku populasi normal. Kajadian diabetes di penderita kanker pankreas ampir dua kali tina populasi normal. Ku alatan éta, penderita tanpa riwayat kulawarga diabetes ujug-ujug mendakan yén aranjeunna kedah dipariksa sacara ati-ati pikeun ngaluarkeun kanker pankreas.
6. Tumor pankreas jinak: Sapertos organ anu sanés, pankréas ogé ngagaduhan seueur tumor jinak. Contona: cystadenoma serous atanapi mucous, tumor pseudopapillary padet, papilloma mucous intraductal, sareng sajabana, anu ogé tiasa dirobih janten kanker pankreas, khususna papilloma mucinous sareng papilloma mucad intraductal.
7. Panyakit lisan: Studies have shown that dental caries and other oral inflammatory diseases can also increase the incidence of pancreatic kanker.
8. Anu sanésna: Pasien poliposis adénomatous kulawarga, lesi jinak anu ngalaman gastrectomy distal, panyakit saluran biliary, reseksi bedah hampru, sareng Helicobacter pylori positip ogé bakal ningkatkeun résiko kanker pankreas.
