Kurapwa kwegomarara rezamu kwakafambira mberi nekukurumidza zvikuru mumakore mashoma apfuura uye pave nekuvandudzwa kutsva mukurapwa kwegomarara rezamu. Mukuru wekutsvagisa Dr Juha Klefstorm pa University of Helsinki uyo ari kushanda kwenguva yakareba mubasa rekutsvakurudza rine chokuita nekenza akawana kuti masero ekenza anogona kurwiswa ne "drug cocktail" iyo inosanganisira chirwere cheshuga metformin uye venetoclax, BCL-2 protein inhibitor inogona kukonzera apoptosis mumasero ekenza. . Chikwata chakaziva metformin mune scan yemishonga inogona kubatsira apoptosis -kuita chiitiko che venetoclax. Venetoclax yakagamuchirwa kurapa mamwe ma leukemias asi isati iri yekurapa kenza yemazamu.
"Mushonga uyu unokanganisa kukanganiswa kwemetabolism iyo yakawanda yeMYC inogadzira tumarara masero. Metformin uye venetoclax, kana yakapihwa pamwechete, yakauraya mazamu bundu maseru mutsika uye yakavharira kukura kwebundu muchipfuva chakashata chisikwa chekukura modhi. Zvakare, mishonga yacho yakanyatso kuuraya iyo fide yakashata yemazamu kukura tishu yakapihwa nevarwere vezamu. Ongororo dzechirwere chezamu dzakatorwa kubva mukurapwa kwakaitwa muHelsinki University Hospital,” Dr. Klefstrom anodaro.
Chero zvazvingava, vanamazvikokota vasati vamboona kuti metformin mukuwedzera kurapwa kwevenetoclax yaingochengeta mamota mukati memiganhu yakafanira chero bedzi mbeva dzine mabundu emuchipfuva akadzikwa dzichirapwa nemishonga; apo kurapwa kwakamira, mapundu akadzoka. Ongororo yacho inoratidza kuti mapundu pakutanga akatakurwa nebundu-kuuraya lymphocytes; zvisinei, mushure mekurapwa ivo vakanyangarika zvakanyanya uye mamwe masero emhondi akataurirana PD-1, chiratidzo chekuramba kupera kwesero.
Kugonesa maseru asingabatike kuti akwanise kurwisa bundu, nyanzvi dzakagadzira imwe nzira yekurapa. Kutanga, vanorova mazamu emazamu neapoptosis-actuating zvinodhaka metformin uye venetoclax kuderedza bvunzo dzebundu uye kumutsa vanouraya lymphocytes. Mushure mekunge mabundu akakosha anyatsodzingwa, mbeva dzakabva dzarapwa nemusanganiswa katatu: metformin, venetoclax uye PD-1-yakatarisana neanopikisa acting agent, iyo inoshandiswa muimmunotherapies kuchengetedza masero emhondi ane simba refu.
Kurapa kenza yemazamu - Dr Heidi Haikala
Muvambi mukuru weongororo iyi Dr Heidi Haikala anoona: venture. "Tine chivimbo pamusoro pezvatakatora uye tarisiro yekuti zvichareva mukana pachipfuva chinokuvadza chevarwere."
“Iyi inyaya isinganzwisisike yekuti vatsvagiri munyika yevadzidzi, vachishandisa mamota ane hunyanzvi uye vachishandisa ruzivo rwavo rwunoshamisa, vanogona kuwedzera mukuburitswa kwemishonga mitsva ingangowanikwa kune vanhu vane kukura kwakashata. Izvi zvinoratidzawo kutsvagisa kunoshamisa kuri kuitwa munyika diki dzakadai seFinland, ”anodaro Joel Leverson, Ph.D., Senior Scientific Director kuAbbVie uye mumwe wevagadziri vakuru mukuferefeta uku.
Tariro mumakore anotevera pachave nekumwe kusimukira mukurapwa kwe kenza yebonde.
