CAR T-Cell Therapy

Pazasi pane mamwe emhedzisiro yeCAR T-Cell therapy.

1. Cytokine release syndrome (CRS): Iyo yakanyanya kupararira uye ingangove yakakosha mhedzisiro yeCAR T-sero kurapwa ndeye cytokine release syndrome (CRS). Zviratidzo zvakaita sefuruu, zvinosanganisira fivha, kupera simba, kutemwa nemusoro, uye kurwadziwa kwemhasuru, zvinounzwa nekugadziridzwa kweT cell 'kugadzirwa kwemacytokines. Mumamiriro ezvinhu akanyanyisa, CRS inogona kukonzera kupisa kwakanyanya, hypotension, kutadza kwenhengo, uye kunyange mhedzisiro inouraya. 
2. Neurological Toxicity: Vamwe varwere vanogona kukudziridza mhedzisiro yetsinga, iyo inogona kusimuka mukuomarara kubva kune zvishoma zvakakomba zviratidzo senge kuvhiringidzika kunyoro uye kuvhiringidzika kune zvakakomba zvakanyanya senge pfari, delirium, uye encephalopathy. Mushure meCAR T-cell infusion, neurological toxicity inowanzoitika mukati mevhiki yekutanga. 
3. Cytopenias: CAR T-sero kurapwa kunogona kukonzera kuderera kwemasero eropa, akadai seanemia (yakaderera masero matsvuku eropa), neutropenia (yakaderera masero eropa eropa), uye thrombocytopenia (yakaderera platelet count). Utachiona, kubuda ropa, uye kupera simba ndedzimwe njodzi dzinogona kuwedzerwa neiyo cytopenias. 
4. Zvirwere: Iyo CAR T-cell kurapa kudzvanyirira kwemasero ane hutano ekudzivirira muviri kunowedzera njodzi yehutachiona, hutachiona, uye fungal utachiona. Kuti udzivise kutapukirwa, varwere vangangoda kutariswa zvakanyanya uye kupihwa mishonga yekudzivirira.
5. Tumor Lysis Syndrome (TLS): Mushure meCAR T-cell therapy, zvinokwanisika mune mamwe mamiriro ezvinhu kuti huwandu hwakawanda hwemukati hubudiswe muropa nekuda kwekukurumidza kuuraya kwebundu maseru. Izvi zvinogona kukonzera kusagadzikana kwemetabolism, senge yakawandisa potassium, uric acid, uye phosphate mazinga, izvo zvinogona kukuvadza itsvo uye kukonzera mamwe matambudziko. 
6. Hypogammaglobulinemia: CAR T-sero kurapwa ine mukana wekudzikisa antibody synthesis, izvo zvinogona kukonzera hypogammaglobulinemia. Izvi zvinogona kuita kuti utachiona hunoramba huchidzokororwa huwedzere uye zvinodaidzira kuenderera mberi kwemishonga yekutsiva masoja ekudzivirira chirwere. 
7. Organ toxicity: CAR T-cell therapy ine mukana wekukuvadza nhengo dzakati wandei dzinosanganisira moyo, mapapu, chiropa, neitsvo. Izvi zvinogona kutungamira kune zvisina kujairika renal basa bvunzo, nyaya dzekufema, nyaya dzemoyo, uye kusakwana kwechiropa basa bvunzo.
8. Hemophagocytic lymphohistiocytosis (HLH): Chirwere chisingawanzoitiki asi zvichida chinouraya chinouraya chinonzi hemophagocytic lymphohistiocytosis (HLH) chinogona kukura semugumisiro weCAR T-cell therapy. Inosanganisira kuwandisa kwemasero ekudzivirira muviri, izvo zvinokonzera kukanganisa kwakakomba kwenhengo uye kuzvimba.
9. Hypotension uye Fluid Retention: Nekuda kweiyo cytokines iyo CAR T masero anoburitsa, vamwe varwere vanogona kukura yakaderera yeropa (hypotension) uye kuchengetwa kwemvura. Kugadzirisa zviratidzo izvi, matanho ekutsigira anosanganisira intravenous fluid uye mishonga inogona kudiwa.
10. Secondary Malignancies: Mishumo yezvirwere zvechipiri zviri kubuda zvichitevera CAR T-cell therapy iripo, zvisinei nekushaikwa kwavo. Tsvagiridzo iri kuitwa parizvino pamusoro pekugona kwechipiri hutsinye uye njodzi dzenguva refu.

Zvakakosha kuyeuka kuti havasi murwere wese achava nemigumisiro iyi, uye kuti nhanho yemunhu wega wega inosiyana. Kuti uderedze uye uderedze zvinokonzeresa zvinokonzeresa izvi, timu yekurapa inoongorora varwere nguva isati yasvika, panguva, uye mushure meCAR T-cell therapy.