Tumor-infiltrating lymphocyte (TIL) kurapwa
A revolutionary approach mukurapa kenza.
Unoda kunyoresa mune iyi yekubudirira kurapwa cancer?
Tumor-infiltrating lymphocyte (TIL) kurapwa inzira inovimbisa mukurapa cancer. Zvinosanganisira kubvisa masero edziviriro, kunyanya T masero, kubva kumota yemurwere. Aya T masero anozokura owanda murabhoritari asati apinzwazve mumuviri womurwere. Chinangwa ndechekusimudzira kugona kwe immune system yekuziva nekurwisa cancer maseru nemazvo. Kurapa kweTIL kunoonekwa senzira yekugamuchira masero ekutamisa, achisimudzira mhinduro yemurwere pachezvake kurwisa bundu. Iyi yakasarudzika immunotherapy inobata mukana wekurapa akasiyana kenza uye inzvimbo inoshanda yekutsvagisa uye kukura kwekiriniki mune oncology.
Kukadzi 2024: A novel cellular immunotherapy ikozvino yapihwa kune varwere vane advanced melanoma. Inozivikanwa se TIL kurapa, iyo inomirira bundu-infiltrating lymphocyte therapy. Iyo imwe-nguva T-cell therapy jekiseni inoshandisa murwere masero ekudzivirira ekurwisa cancer. Aka ndekekutanga kurapwa kwesero kwemamota akasimba kugamuchira mvumo yeFDA.
Clinical study data inoratidza kuti mushonga wenguva imwe chete waive ne36% yekupindura mwero muvanhu vane metastatic melanoma, inova mhedzisiro yakanaka tichifunga kuti kurapa uku kwakaedzwa muvarwere vane chirwere chakawedzera mushure mekuita mhando dzakasiyana dze immunotherapy. Varwere vakawanawo mhinduro dzenguva refu, dzinogara makore anopfuura maviri.
Tumor-infiltrating lymphocyte (TIL) kurapa inzira yekucheka-kumucheto immunotherapy inoshandisa immune system yemurwere kurwisa cancer. Kurapwa kwazvino kunorongedzerwa seadoptive cell transfer (ACT), umo masero ezvirwere zvemurwere anobviswa, oshandiswa, kana kukwidziridzwa murabhoritari asati adzoserwa mumurwere kuti anange nekupedza maseru egomarara.
Iyo TIL therapy inoshanda sei?
Kurapa kweTIL kunosanganisira kuunganidza T-lymphocytes (T-cells) kubva mubundu rakavhiyiwa. Masero aya anobva awedzerwa murabhoritari kuti avandudze kugona kwavo kurwisa gomarara nekusarudza nekuwanza maT-cell ane simba zvikuru. Aya maseru anodzoserwa mumurwere nekupinzwa zvichitevera induction chemotherapy. Iwo achangochaja T-masero anoenda mumuviri wese, achirwisa nekuuraya masero emamota.
Chii chinonzi TIL therapy?
Tumor-infiltrating lymphocyte (TIL) kurapa ishanduko yemhando yeimmunotherapy inosunga immune system yemurwere kuti irwise cancer zvine mutsindo. Heino chidimbu chizere chemaitiro anobatanidzwa muTIL kurapwa zvichibva pane data rakawanikwa kubva kune akawanda masosi:
Kubviswa kweT-lymphocytes: Kurapa kweTIL kunotanga nekukohwewa kweT masero kubva mubundu rakavhiyiwa. Aya T-masero akakosha zvikamu zve immune system, kuona uye kubvisa cancer maseru.
Kuvandudza Marabhoritari: MaT-cell anotorwa anobva atakurwa kuenda kurabhoritari, uko anogadziridzwa uye anokwidziridzwa kuti avandudze kugona kwawo kurwisa cancer. Iyi nzira inosanganisira kunhonga ane simba T-masero uye nekuadzokorora kuti avake immune system ine simba.
Infusion Kudzokera mumurwere: Kana maTIL achinge anyatsowedzerwa kusvika kumabhiriyoni emasero, anodzoserwa mumurwere nekupinza. Aya ma-T-seli akaiswa ma-supercharged akarongwa kuti aone uye arwise maseru egomarara achidzivirira maseru ane hutano.
Induction Chemotherapy: Pamberi pekuiswa kweTILs, varwere vanowanzogamuchira kosi yevhiki imwe yechemotherapy kubvumira maT-seli achangobva kuunzwa kuti awedzere kubudirira mukati memuviri. Ichi chikamu chakakosha pakuwedzera kugona kwekurapa kweTIL kurapwa.
Nguva Yekurapa: Kusiyana nemamwe akawanda marapirwo egomarara anoda kuramba achitarisirwa, kurapwa kweTIL kunowanzo kupihwa kamwe chete. Nekudaro, kana varwere vakambobatsirwa neTIL kurapwa uye vachida kumwe kurapwa, kutenderera kwechipiri kwekurapa kunogona kutariswa.
TIL therapy ine kazhinji ine mwero yakaipa mhedzisiro, ine zviratidzo zvinowanzoitika zvinosanganisira fivha, kutonhora, uye kupfupika kwekufema. Izvi zvinokonzeresa zvinogara zvichinzi kune zvimwe zvikamu zvekurapa regimen kwete TIL masero ivo pachavo.
Kurapa kweTIL kunosiyana neCAR-T cell therapy pakuti inokura maTIL zvakananga kubva mubundu pane kuachinja genetically. Uyezve, zvigadzirwa zveTIL zvine polyclonal, zvinosanganisira akati wandei T-cell clones inokwanisa kunanga yakafara spectrum ye tumor antigens.
Kupfupisa, TIL kurapwa inzira inovimbisa yekurapa cancer sezvo ichishandisa nemazvo immune system yemurwere kurwisa cancer. Mushonga uyu unoshamisa une mukana wakakura wekurapa hutsinye hwakasiyana uye unopa tariro nyowani kune varwere vasina kupindura kune yechinyakare immunotherapies.
Unogona kuda kuverenga: TIL kurapwa muChina
Kufambira mberi uye Kushandiswa kweTIL kurapwa
Dr. Steven Rosenberg akabudirira kurapa mbeva yakaipa ne autologous TILs mukupera kwema1980, paakatanga kugadzira TIL therapy. Kubva ipapo, kurapa kweTIL kwakakwira zvakanyanya, kuratidza kushanda kukuru mumamota akasimba, kunyanya melanoma, cancer yecervical, uye colorectal cancer.
Grit Biotechnology, inotungamirwa kuShanghai, yakawana mari inosvika mamirioni makumi matanhatu emadhora muSeries B mari yekufambisira mberi budiriro yevanokwikwidza muTIL, ichinyanya kukoshesa melanoma, gomarara remuchibereko, uye remapapu. Kuedza uku kunoenderana nepasirese mapatani muTIL therapy, iyo inowanzobatanidza marapirwo akasanganiswa nemamwe ma immunotherapies, senge immune cheki inovharira mishonga.
Zvidzidzo zvenguva pfupi yapfuura zvakasimbisa kuti kuumbwa uye nzvimbo yeTILs mukati memamota zvinhu zvakakosha zvinokanganisa kufungidzira uye kurapwa. Kunzwisisa hukama hwakaoma pakati peTILs uye tumor microenvironment kwakakosha mukusimudzira kurapa kweTIL kunoenderana nemhando dzebundu uye kunatsa kupatsanurwa kwevarwere.
Ko TIL therapy yakasiyana sei ne immunotherapy?
Kusiyana Pakati peTIL Therapy uye Mamwe Marudzi eImmunotherapy
Tumor-infiltrating lymphocyte (TIL) therapy inomira kubva kune dzimwe nzira dzekudzivirira zvirwere nekuda kwezvimiro zvayo zvakasiyana uye maitiro. Heino misiyano yakakosha pakati peTIL kurapwa uye mamwe marudzi e immunotherapy, zvichienderana neruzivo rwakatorwa kubva kune anovimbika masosi:
1. Kunobva Sero uye Kugadziridzwa: - TIL kurapwa inzira yekuunganidza T-masero zvakananga kubva mubundu rakabviswa panguva yekuvhiyiwa. Aya maseru anozorimwa murabhoritari isina genetic manipulation, iyo inovandudza kugona kwavo kwechisikigo kunongedza maseru egomarara.
CAR-T Cell Therapy: Kusiyana neizvi, CAR-T cell therapy inorongazve T-masero emurwere murabhoritari kuti azive mapuroteni chaiwo pamasero egomarara. Aya maseru akagadziridzwa genetically anodzoserwa mumurwere kurwisa cancer maseru.
2. Mhando dzeCancer Yanangwa: Kurapwa kweTIL kwave kubatsira mukurapa mabundu akasimba senge musoro nemutsipa squamous cell carcinoma, melanoma, cancer yemapapu, uye gynecological malignancies. Inonyanya kushanda kune zvakaipa zvakapararira kune dzimwe nzvimbo dzemuviri.
CAR-T Cell Therapy: CAR-T cell therapy inowanzo shandiswa kurapa malignancies eropa senge leukemia nelymphoma nekunanga chaiwo mamaki pamasero egomarara. Kurapa kweTIL, kune rumwe rutivi, kunogona kushanda zvakanyanya kurwisa mabundu akasimba nekuti inogona kuona huwandu hwakakura hwemabundu mamaki.
3. Nzira yeMabasa: TILs dzinongoitika masero edziviriro anopinda mumamota uye anozowedzerwa murabhoritari asati adzoserwa kumuviri wemurwere. Aya maseru anonangana neakasiyana siyana ematundu antigens anoonekwa mumamota akasimba.
CAR-T Cell Therapy: CAR-T cells are designed to express chimeric antigen receptors that specifically detect antigens on cancer cells. This therapy is extremely specific to recognized antigens found in blood cancer cells.
4. Nguva Yekurapa uye Maside Effects: -TIL therapy inowanzoitwa kamwe chete, nevarwere vanogamuchira induction chemotherapy pamberi peTIL infusion. Kazhinji, mhedzisiro yeTIL kurapwa haina basa uye inowanzobva kune zvimwe zvinhu zvechirongwa chekurapa kwete masero eTIL pachawo.
CAR-T Cell Therapy: CAR-T cell therapy inogona kuita kuti infusions yakawanda uye inogona kuguma nemigumisiro yakaipa yakadai se cytokine release syndrome uye neurotoxicity nekuda kwekukurumidza kukurudzirwa kwemhinduro dzekudzivirira zvirwere.
Muchidimbu, TIL therapy uye CAR-T cell therapy ese ari maviri ekugamuchira maseru ekutamisa immunotherapies, zvisinei, iwo anosiyana zvakanyanya maererano ne immune cell sosi, mhando dzegomarara rinonangwa, maitiro echiito, uye zvine chekuita nemhedzisiro. TIL kurapa inzira inogoneka yekurapa cancer nekuda kwekushandisa kwayo kwakafara kurwisa mabundu akasimba uye kuvimba nemhinduro dzagara dziripo.
Unogona kuda kuverenga: CAR T-Cell kurapa muChina
Zvirwere zvinobatwa zvakanaka neTIL kurapwa
- Musoro & mutsipa squamous cell carcinoma
- Melanoma
- Kanza yemaperembudzi
- Kanzera dzeGenitourinary
- Zvimwe zvakashata
Kana iwe wakamboonekwa uine melanoma, kunyangwe kana melanoma yako iri metastatic kana yapararira, pane tariro. Hutsva kurapwa kurapwa kunoita kunonoka kwepamberi melanoma kupona Imwe yemarapirwo anobudirira ndeye bundu rinopinda mukati lymphocyte (TIL) immunotherapy.
Ndeapi maside-effects eTIL therapy?
Nepo tumor-infiltrating lymphocyte (TIL) kurapa kuri kuvimbisa kurapwa kwegomarara, inogona kuve nemhedzisiro yakaipa.
Heino tsananguro izere yezvingangoitika zvisina kunaka mhedzisiro yakabatana neTIL kurapwa kwakavakirwa paruzivo kubva kune anovimbika masosi:
1. Migumisiro Yepakarepo:
- Fever uye Chills. Varwere vanogona kukura kupisa kwakanyanya uye kutonhora paTIL infusion.
-Nausea uye Kurasikirwa Kwekudya: Vamwe vanhu vanogona kusangana nekusvotwa uye kuderera kwechido mushure meTIL kurapwa.
-Neurological Symptom: Musoro, dzungu, uye mamwe matambudziko etsinga anogona kuitika.
- Kuneta: Varwere vanogona kunge vaine kuneta kwakanyanya uye kushaya simba nekuda kwekurapwa.
– Fluid Retention: Muviri unogona kuunganidza zvinwiwa, zvichikonzera kuzvimba.
2. Chemotherapy ine chokuita neSide Effects:
-Low Blood Counts: Chemotherapy isati yasvika TIL infusion inogona kukonzera kuderera kweropa, inoda kuwedzerwa ropa.
Zvirwere: Chirwere chemuviri chisina simba panguva yekemotherapy chinowedzera kukanganisa kuhutachiona.
-Hairloss: Vamwe vanhu vanogona kutanga kurasikirwa nebvudzi nekuda kwekugadzirisa chemotherapy.
– Maronda emumuromo: Chemotherapy inogona kukonzera maronda emukanwa.
3. Kuongorora Kwenguva Yakareba:
- Chikwata chemultidisciplinary chemaoncologists, vanamukoti, uye vamwe vanachiremba vanotarisisa varwere vari kurapwa neTIL kune matambudziko angangoitika.
-Kugadzwa kwekutevera kunosanganisira kuongorora huwandu hweropa, kutarisa matambudziko, uye kuita maekiseni ekufungidzira kuona mhinduro yebundu.
4. Matanho Ekutungamira:
TIL therapy yakashata mhedzisiro inoderedzwa nekutarisa nguva dzose uye mushure mekurapa kurapwa.
- Vanachiremba oncologists vanopa zano rakakwana rekugadzirisa mhedzisiro uye matambudziko.
5. Kurapa kweTIL kunosiyana neCAR-T cell therapy pakuti inoshandisa maT-cell anongoitika anotorwa kubva kumamota, pane kuachinja murabhoritari. Migumisiro yakaipa yeTIL therapy inowanzokonzerwa kune zvimwe zvikamu muchirongwa chekurapa kwete masero eTIL pachavo.
Mukupedzisa, nepo TIL kurapwa iine vimbiso huru yekurapwa kwegomarara, varwere vanofanirwa kurangarira zvingangove zvakashata mhedzisiro yeino novel immunotherapy zano. Kunyatsotariswa nevashandi vehutano uye kutarisisa kune post-kurapwa miitiro yekutarisira kwakakosha kuti ubudirire kugadzirisa izvi zvakaipa zvinokonzeresa.
Ndeipi mutengo weTIL kurapwa?
Mutengo weTumor-Infiltrating Lymphocyte (TIL) kurapwa zvinosiyana zvichienderana nehuwandu hwemaitiro. Heino pfupiso yemitengo inofungidzirwa yakabatana neTIL kurapwa zvichibva pane ruzivo rwakatorwa kubva kune anovimbika masosi:
1. Kuparadzana Kwemitengo:
Kuongorora: Kuongororwa kwemuviri, kuongororwa ropa, uye kubvunzana zvinodhura zvakanyanya $ 3000.
Kuparadzaniswa kweTILs: Ichi chikamu chinoda kuvhiyiwa, mazuva ekuchipatara, uye kubvunzana, uye inodhura avhareji ye $ 4000 USD.
TIL Kugadzirwa: Mari yekugadzira inosiyana pakati pemadhora makumi mana nemakumi matanhatu nemakumi matanhatu emadhora, zvichienderana nehuwandu hwezvigadzirwa pagore (gumi kana 40,000 varwere).
2. Inofungidzirwa Yese Mutengo: Yekutanga fungidziro yekurapa murwere mumwechete neTIL kurapwa iripo $ 65,000.
Munyika dzakaita seUnited States, mutengo unofungidzirwa wekurapwa weTIL unotangira pamadhora makumi mapfumbamwe nemakumi matanhatu nemazana matanhatu kusvika pamadhora zana nemakumi matanhatu nesere, makumi mana nemakumi mana epamurwere.
KuCanada neUnited Kingdom, mitengo yemitengo iC $89,072-C$116,295 uye £32,945-£60,608, zvichiteerana.
Sekureva kwechiitiko chemurwere chazvino uye data, Kurapa kweTIL kuchadhura madhora zviuru zana nemakumi maviri neshanu muIsrael uye chero chinhu chiri pakati pemadhora makumi matanhatu negumi nemakumi maviri neshanu muChina. Mutengo weTIL kurapwa unosiyana zvakanyanya nerudzi uye nhanho yegomarara. Sezvo kurapa uku kuchiri mukiriniki yekuyedza nhanho, fungidziro yemutengo wakatarwa inenge isingaite.
3. Zvinhu Zvinokanganisa Mari: -TIL mari yekurapa inokanganiswa nekugadzirwa uye kutonga.
-Kuvakwa kwezvivakwa zvekugadzira uye kugona musero kurapwa kunogona kuve nemhedzisiro pamitengo yese.
4. Mutengo-Kubudirira: - TIL kurapwa inodhura-inoshanda kana ichienzaniswa nemamwe marapirwo akadai seipilimumab.
5. Kuvepo uye Zvipingamupinyi zvinodzorwa: -Kurapwa kweTIL kunongopihwa munzvimbo dzakashongedzerwa pasi rese kuburikidza nemiedzo yekiriniki kana zvirongwa zvekusvika kwekutanga nekuda kwezvipingaidzo zvekudzora nekugadzira.
6. Side Effects Management: -Yakajairika mhedzisiro yeTIL kurapwa inosanganisira fivha, kutonhora, kuda kurutsa, kurutsa, manyoka, uye kupera simba. Izvi zvakashata zvinogara zvichiongororwa nevarapi vehutano panguva yese yekurapa.
Mukupedzisa, nepo Tumor-Infiltrating Lymphocyte (TIL) therapy inoratidza kugona mukurapa kenza, ine mari yakawanda inosiyana zvichienderana nenzvimbo uye maitiro ekurapa. Kunyatsotarisisa kwemhedzisiro uye manejimendi akakodzera zvikamu zvakakosha zvehurongwa hwese hwekurapa.
Tsvakurudzo inoenderera mberi uye maonero emangwana
Nepo kurapwa kweTIL parizvino kuri kutorwa sekuyedza, vaongorori vari kuongorora kubatsira kwayo mumhando dzakasiyana dzegomarara. Kubudirira kwekurapa kwekurapa, kunyanya muzviitiko zve melanoma, kwakakurudzira tsvakiridzo yekuwedzera mukugona kushandiswa kwayo kune huwandu hwakawanda hwezvirwere. Vatsvagiri vari kuongororawo tarisiro yekuchengetedza masero eTIL kuti azoshandiswa gare gare se "top-up" kurapwa kana gomarara rikadzoka.
Kupfupisa, kurapwa kweTIL kufambira mberi kwakakosha mukurapa cancer, ichipa tariro nyowani kuvarwere vasina kupindura kune yechinyakare immunotherapies. Mushonga uyu une mukana wakakura weramangwana reoncology nekuda kwekugona kwayo kubudirira kunanga nekupedza maseru egomarara uchishandisa immune system yemuviri.