FUCASO kurapwa muChina
Huwandu hwekupindura kweiyi revolutionary cancer therapy inonzi FUCASO iri 96%. Mvumo yeNMPA inoratidza shanduko mukurwisa kweChina kurwisa multiple myeloma. Iyi blog inoongorora kushanda kwekurapa uku, kuchengetedzeka kwayo, uye kugona kwayo kugadzirisa mhedzisiro yevarwere. Dive mukati uye udzidze zvakawanda nezveFUCASO uye tariro yainounza yekuramba akawanda myeloma varwere.
Multiple myeloma, a gomarara reropa iyo inobata masero eplasma, inogona kuva mupikisi anotyisa. Inoderedza kusadzivirirwa, uye inoderedza mapfupa, uye, pasinei nekufambira mberi, zvichiri kuoma kuwana mishonga yenguva refu. Multiple myeloma inofungidzirwa kubata vanhu vangangosvika 176,404 pasi rese muna 2020.
Multiple myeloma ndiyo yechipiri yakanyanya kupararira mhando yegomarara reropa, mushure lymphoma, asi zvichiri kuonekwa sezvishoma. Inowanzoonekwa muvanhu vakwegura, neavhareji yezera rekuongororwa inosvika makumi manomwe. Asi kune chiedza chetariro nekufambira mberi CAR T cell kurapwa muChina.
China's National Medical Products Administration (NMPA) ichangobva kubvumira BCMA itsva CAR T cell kurapwa kwegomarara muChina inodaidzwa kuti FUCASO, ichimaka mukana wekuchinja mukurwisa chirwere ichi chakaoma. Saka, chii chinonzi myeloma yakawanda, uye nei FUCASO ichigadzira kufara kwakadaro?
Zvidzidzo zvenguva pfupi yapfuura zvinoratidza vimbiso inoshamisa panguva yekuedzwa, nehuwandu hwekupindura huwandu hwe96% uye huwandu hwekupindura hwakakwana hwe74.3% hwakaonekwa mu103 vakanyoresa varwere. Iyi blog inonyura zvakadzika musainzi kuseri kweFUCASO, kukanganisa kwayo kune varwere ve myeloma, uye tariro yainounza kuhondo yepasi rose yekurwisa chirwere ichi chakaoma.
Iko mutengo wakakwira wakabatana nekurapa cancer unokuita kuti unzwe kuremerwa nemafungiro asina kunaka?
Hapana chikonzero chekunetseka zvakanyanya! Ingodzvanya pano uye uwane kurapwa kenza pasina muChina izvo zviri kupa tariro itsva kuvarwere pasi rose.
Chii chinonzi Multiple Myeloma Disease?
Multiple myeloma, inowanzonzi plasma cell myeloma kana kuti myeloma chete, igomarara remasero eplasma, ari masero machena eropa anowanikwa mumwongo. Masero eplasma anowanzo gadzira masoja ekudzivirira chirwere, ari mapuroteni anobatsira muviri wako kurwisa utachiona.
Maseru eplasma mune akawanda myeloma anokura zvisina kujairika uye anowedzera zvisingadzoreki. Aya masero eplasma asina kujairika anopinza kunze masero eropa ane hutano mumwongo wepfupa, zvichikonzera kugadzirwa kweM mapuroteni asina kujairika.
Tsvaga Zviratidzo: Gwaro Rinodzidzisa Pazviratidzo zvekuzevezera uye Zviratidzo zveMyeloma yakawanda
Impact ye Multiple Myeloma Pamuviri Wemunhu:
Kukuvadzwa kwepfupa: M mapuroteni uye masero eplasma asina kujairika anogona kukuvadza mapfupa emapfupa, zvichiita kuti marwadzo, kuputsika, uye osteoporosis.
Zvinetso zvetsvo: M mapuroteni anogona kuunganidza muitsvo uye kukanganisa basa ravo.
Anemia: Kuwanda kwemasero eropa ane hutano nemasero eplasma asina kujairika kunogona kutungamirira kuanemia, zvichikonzera kuneta uye kupera kwekufema.
Kusadzivirirwa kwekudzivirira muviri: Masero eplasma asina kujairika haakwanise kugadzira masoja ekudzivirira chirwere, zvichiita kuti muviri uve munjodzi yekutapukirwa.
Verenga Izvi: Maitiro eDiagnostic Imaging Anoponesa Hupenyu muMazhinji Myeloma Hondo?
Sainzi Kuseri kweFUCASO Kurapa Kune Yakawanda Myeloma muChina
FUCASO (Equecabtagene Autoleucel) yakafanana nekurapa kwegomarara pasi pegomarara rakaomarara rinodaidzwa kuti multiple myeloma, kunyanya kune vanhu vane gomarara rakadzoka mushure mekurapwa kwakamboitwa (kudzokororwa kana kudzoreredza multiple myeloma, RRMM).
Kurapa kwakakosha uku kunoshandisa simba re immune system yemunhu kurwisa gomarara nenzira yemunhu uye inogona kurapa. Mukurapa uku, masero eT anogadziridzwa nemareceptor akakosha anonzi maCARs (Chimeric Antigen Receptors), achiaita senge mapfumo anotungamirwa anogona kuziva uye kurwisa zvakanangana nekenza maseru. FUCASO kurapwa kweyakawanda myeloma muChina yakasarudzika nekuda kwezvikonzero zvishoma zvakakosha:
Akazara-Munhu: Kusiyana nemamwe marapirwo akafanana, FUCASO inoshandisa zvachose zvikamu zvevanhu, zvichiita kuti isanyanya kukonzera kurambwa nemhedzisiro.
BCMA-Yakajeka: Iyo CAR muFUCASO inonangana neBCMA, puroteni inowanikwa zvakanyanya mumaseru emyeloma. Kururama uku kunoderedza kuwanda kwekukuvadza kune hutano hutano.
Lentivirus As A Gene Vector: Iyi inzira inoshanda kwazvo yekuunza majini kuT cell. Inobvumira T lymphocytes kuziva uye kuparadza myeloma masero.
Ine Simba Uye inorambira: FUCASO yakaedzwa zvakanyanya uye yakawanikwa ichishanda zvakanyanya uye inogara kwenguva refu muvarwere vane myeloma yakawanda, ichipa tariro yekuregererwa kwenguva refu.
China's National Medical Products Administration (NMPA) nguva pfupi yadarika yakapa mwenje wakasvibira weFUCASO® kuti ushandiswe mukurapa akawanda myeloma. Nekuda kwekuedza kweInnovent Biologics uye IASO Bio, kurapwa kwakafanana negamba kwave kuwanikwa, kunoratidza danho rakakura kumberi mukurwisa chirwere ichi chakaoma. Uku kurapwa kwechitsva kunounza mwaranzi mutsva wetariro yeramangwana rakajeka.
Uyewo verenga: Immunotherapy Inogona Kukubatsira Iwe Kuhwina Hondo Yekurwisa Multiple Myeloma!
Chii Chakaitika Panguva Yekuyedzwa kweFUCASO Kurapwa Kweakawanda Myeloma muChina?
Iyo FUMANBA-1 kliniki yekuedzwa, yakaitwa muChina, yakaongorora kushanda uye kuchengeteka kweFUCASO (Equecabtagene Autoleucel) kune varwere vane kudzokazve kana kuti refractory multiple myeloma (RRMM). Muyedzo uyu waisanganisira varwere zana nevatatu mumwe nemumwe akawana dosi rimwe chete reFUCASO, CAR-T cell therapy yegomarara muChina.
Mhedzisiro yechidzidzo chekiriniki iyi yainakidza zvechokwadi:
Nhamba yepamusoro yekupindura: 96% yevarwere vakapindura kurapwa, ne74.3% vachiwana mhinduro yakakwana (sCR) kana mhinduro yakakwana (CR), zvinoreva kuti pakanga pasina masero ekenza anozivikanwa.
Kukurumidza kupindura: Nguva yepakati yekupindura yaingova mazuva gumi nematanhatu, ichiratidza kukurumidza kukanganisa pachirwere.
Durable remissions: Pamwedzi gumi nemiviri, 12% yevarwere vakanga vachiri kufambira mberi-pasina, vachiratidza kushanda kwenguva refu kwekurapa.
Deep remissions: 95% yevarwere vakawana zvishoma residual chirwere (MRD) negative, zvinoreva kuti kwaive nekenza shoma isingaonekwe.
Kubudirira muvarwere vakanyanya kurapwa: Kunyange varwere vakanga vagamuchira kare CAR-T kurapwa vakapindura zvakanaka, ne 9 vachiwana CR uye 5 vachiwana sCR.
Yakanaka chengetedzo mbiri: Vashoma vanhu vakasangana nediki mhedzisiro senge cytokine release syndrome kana neurotoxicity, uye vese vakapora.
Kushingirira kwekurapa: Pa12 uye 24 mwedzi, masero eFUCASO akaonekwa muchikamu chikuru chevarwere, zvichiratidza mukana wekuita kwenguva refu.
Idzi data, dzakaunzwa pamusangano weAmerican Society of Clinical Oncology muna 2023, dzinoratidza vimbiso yeFUCASO seyakabudirira zvikuru uye inotenderwa zvakanaka kurapwa kwemyeloma yakawanda.
Ndeupi Mutengo Wekurapa kweFUCASO Kune Yakawanda Myeloma muChina?
Mutengo wekurapwa kweFUCASO kune akawanda myeloma muChina ungangoita $160,000 USD. Kunyange zvazvo izvi zvingaita semari yakawanda, zvakakosha kuziva kuti kurapwa uku inhanho inokosha mukubatsira vanhu vane myeloma yakawanda.
Inopa mukana wekuvandudza mhedzisiro uye hupenyu huri nani. Kana uri kufunga nezvekurapa uku, ipfungwa yakanaka kubvunza vanachiremba vako kana kutibata kuti ubatsirwe nemari kana usingakwanise kubhadhara mutengo wekurapwa.
Mari yakashandiswa patsva iyi CAR T cell kurapa kuChina hakusi kwekungobhadhara mari yekurapwa – kudyara mune imwe nzira iri nani yekurwisa kuwanda kwemyeloma.
Zvipatara Zvakanakisa ZveFUCASO Kurapa Kune Yakawanda Myeloma MuChina
Rega tikubatsire iwe kuwana zvimwe zvezvakanakisa zvipatara muChina zvinopa FUCASO kurapwa kune akawanda myeloma.
Peking University Cancer Hospital
Peking University Cancer Hospital inzvimbo inozivikanwa inoonekwa seimwe yenzvimbo dzeChina dzekurapa cancer. Iyo iri padanho rekucheka rekuvandudza kwezvekurapa, inogara ichisundira miganhu yekutsvagisa cancer, kuongororwa, uye kurapwa.
Sezvineiwo, Peking University Cancer Hospital ndiye piyona muCAR T cell therapy, ichipa iyi yakasarudzika nzira yekurapa kuvarwere vakatarisana neakasiyana kenza, kusanganisira akawanda myeloma.
Saka, kana uri kufunga nezveCAR T cell therapy yemultiple myeloma, chipatara ichi pasina mubvunzo inzvimbo ine mukurumbira inofanirwa kuongororwa.
Shanghai Changzheng Hospital
Chipatara cheChangzheng, chiri mukati memoyo weShanghai, muenzaniso unopenya wehunyanzvi hwekurapa, uchipa marapirwo akasarudzika akadai seCAR T cell therapy yeakasiyana eropa kenza, kusanganisira akawanda myeloma.
Chipatara cheChangzheng Dhipatimendi reHematology chinotungamira chirongwa cheCAR T cell therapy, ichishandisa makore ayo ehunyanzvi uye michina yemhando yepamusoro kupa zvirongwa zvekurapa zvemunhu.
Chikwata chavo chakazvipira chehematologists, oncologists, uye vanamukoti vanoshanda pamwe chete kuona kuti murwere wega wega awana rubatsiro rwemhando yepamusoro mukati merwendo rwekurapwa.
Chipatara cheLu-Daopei
Dr. Lu Daopei, nyanzvi yehematologist yakakurumbira, akatanga Lu-Daopei Hospital, iyo yakazvisimbisa semutungamiri mukurapa kwechirwere cheropa nekutsvakurudza muChina. Zvikuru, vane ruzivo rwakakura neCAR-T cell kurapwa, vachipa iyi shanduko kune varwere vari kurwisa akawanda myeloma nemamwe magomarara.
Ndivo vaive vekutanga muChina kushandisa masero eCAR-T kurapa B-cell acute lymphoblastic leukemia (B-ALL) uye kubvira zvino vakaita zvinopfuura mazana matatu zvakabudirira nzira dzeCAR-T dzekenza dzeropa dzakasiyana.
Beijing Gobroad Boren Hospital
Dhipatimendi rehematology paBeijing Gobroad Boren Hospital rinonyanya kugadzirisa matambudziko ehematological ane anopfuura makore makumi matatu eruzivo rwakadzama mukiriniki yemukati uye marabhoritari marongero.
Dhipatimendi rinopa huwandu hwakazara hwekuongorora uye kurapwa masevhisi ezvirwere zvakaita seyakawanda myeloma, leukemia, lymphoma, thalassemia, coagulation matambudziko, uye hematological tumors.
Kana zvasvika kune nzira dzekurapa, vanopa huwandu hwakawanda hwekurapa kwehematologic tumors, kusanganisira: chemotherapy, immunotherapy, yakanangwa kurapa, uye radiotherapy.
Svika KuCancerFax Kuti uwane Rubatsiro rwakawanda rweMyeloma Kurapwa
Kana iwe kana mudiwa ari kubata nemultiple myeloma, CancerFax iri pano kuti ikubatsire. Isu takaita semufambidzani ane hushamwari munzira yako yekuvandudza hutano.
CancerFax inoshanda nezvipatara zvekutanga zvegomarara pasirese, kusanganisira MD Anderson, Memorial Sloan Kettering, uye Mayo Clinic, kubatsira varwere vari kutsvaga maonero echipiri kana hunyanzvi hwekurapwa kuwana marapirwo emazuva ano.
Kwemakore gumi apfuura, tanga tichibatsira vanhu vanobva kunyika dzinopfuura 8, uye takagadzirira kukutsigirawo. Bata isu nhasi kuti tiongorore akanakisa CAR T Cell kurapa sarudzo muChina uye tanga nzira yako yekunzwa zvirinani.
Bioocus ikambani inotungamira yebiotechnology muChina uye yakagamuchira kodzero dzekuparadzira kurapa uku muIndia, Pakistan, Bangladesh, Africa, uye Middle East.
