Zvirwere zvetsinga matambudziko makuru pasi rose nekuti zvinokonzeresa kufa nekuremara kwakawanda. Kurapa kwechivanhu hakuna kushanda nguva dzose, izvo zvakonzera shanduko kune nzira itsva senge cell-based therapies. Nemhaka yokuti ane simba rakawanda uye anogona kuchinja kuva masero akasiyana-siyana, mesenchymal stem masero (MSCs) ave sarudzo yakanaka ye allogenic cell treatment. Aya maseru, anobva ku mesoderm uye ectoderm, anogona kukwanisa kubatsira kurapa zvirwere zvetsinga nekuchinja kuita masero akaita seneuron, achikanganisa immune system, uye kukurudzira neurogeneration.
Ndeapi Mesenchymal Stem Cells Anogadzirwa Ne?
MSCs isiri-hematopoietic cell precursors inogona kuwanikwa mumatishu eese ari kukura embryos uye vakuru. Vanogona kuita makopi avo uye kuchinja kuva marudzi akasiyana-siyana emasero, izvo zvinoita kuti zvive zvakakosha pahutano hwehutano. Shoko rekuti “mesenchymal” rinobva pakuti dzinobva kufetus connective tissue, kunova ndiko kunogadzirwa mapfupa, cartilage, uye tsandanyama. Nekuti anogona kuve akawanda akasiyana marudzi emaseru, maMSC anoratidza mamwe mamaki epamusoro uye ane mukana we allogenic cell therapy.
Kugona Kwekurapa muNeurological Disorders
Vatsvaguri vakaona kuti guvhu remunhu mesenchymal stem masero (hUC-MSCs) anogona kudzivirira ma neuron nekuamisa kuti asafe. Vanoita izvi kubudikidza kuburitsa cytokines uye neurotrophic zvinhu zvinobatsira neurons kukura zvakare. Nekuda kwehunhu uhu, maMSC anogona kushandiswa kurapa zvirwere zvehuropi zvakaita seAlzheimer's uye sitiroko. Kunyangwe vaongorori vachiri kushanda kuti vavandudze MSC-based therapies, zvichiri kunetsa kushandisa zvizere chivimbiso chavo kurapa yakaoma neurological kusagadzikana.
Mukupedzisa, mesenchymal stem cell therapy inzira itsva inoratidza zvakawanda zvinogona mukurapa kwehutano hwehutano. Kunyange kutsvagisa kwakawanda kuchidikanwa kugadzirisa matambudziko aripo uye kugadzirisa mhedzisiro yekurapa, MSCs inzira ine mativi mazhinji ine mukana wakawanda wekuita kuti hupenyu hwevanhu vane tsinga huve nani.
Unogona kuda kuverenga: Tsika cell kurapwa
Ndeapi mabhenefiti e mesenchymal stem cell therapy kune neurological kusagadzikana?
Mhedzisiro yezvidzidzo inoratidza kuti mesenchymal stem cell therapy inogona kubatsira nehuwandu hwematambudziko eurological, kusanganisira:
Neuroprotection uye Anti-Apoptotic Migumisiro: Mesenchymal stem masero (MSCs) anobatsira kuchengetedza neurons nekuburitsa cytokines uye neurotrophic zvinhu zvinokurudzira neurogeneration. Izvi zvinogona kubatsira kurapa mamiriro akaita sechirwere cheAlzheimer uye sitiroko.
Kuvandudza Kudzoreredza kubva kuIschemic Stroke: Tsvagiridzo yakaratidza kuti MSC transplantation inogona kubatsira vanhu kupora nekukurumidza kubva kune ischemic sitiroko. Izvi zvinoratidza kuti MSC-based therapy inogona kushandiswa kurapa neurological mamiriro.
Multimodal Kurapa kweNervous System Repair: In vitro uye preclinical zvidzidzo zvakaratidza kuti MSCs anobatsira pakugadzirisa sisitimu yetsinga mune akati wandei ezvirwere nekuti ane akakosha zvivakwa.
Mabhenefiti Akakosha muMhuka Models uye Varwere: Zvidzidzo zvakaratidza kuti maMSC ane mabhenefiti akakosha mumhando dzemhuka dzezvirwere zvetsinga uye varwere vane kukuvara kwetsinga. Izvi zvinosimbisa vimbiso yeMSC kurapa yekuvandudza mhedzisiro muhutano hwetsinga.
Mukupedzisa, mesenchymal stem cell therapy inoratidza chivimbiso mukudzivirira neurons, kukurumidza kupora kubva pasitiroko, kupa nzira yemultimodal yekugadzirisa hurongwa hwetsinga, uye kuratidza mabhenefiti makuru mumhando dzose dzemhuka uye vanhu vane chirwere chetsinga.
Ndezvipi zvingangoitika zve mesenchymal stem cell therapy yehutano hwetsinga?
Zvimwe zvinogona kuitika pakushandisa mesenchymal stem masero kurapa zvirwere zvetsinga ndezvi:
1. Immune reaction: Allogeneic MSC transplantation inogona kukonzera mhinduro yekudzivirira muviri, izvo zvinogona kukonzera matambudziko akaita segraft-versus-host disease (GvHD) kana kuti muviri kuramba maseru akatumirwa.
2. Tumor kuumbwa: Nekuti MSC haisati yapatsanurwa, pane mukana mudiki asi chaiwo wekuti bundu richaumbwa.
3. Kurwara: Nekuda kwekuti immune system yavo inopera simba panguva yekurapwa, vanhu vasina immunocompromised vanowana MSC kurapwa vanogona kunge vaine mukana wekutapukirwa.
4. Kugadzirwa kweTeratoma: Nekuti MSCs inogona kushanduka kuita marudzi mazhinji akasiyana emaseru, pane njodzi inogona kuitika yekuumbwa kwe teratoma, inova rudzi rwebundu risingawanzo.
5. Vascular complications: MSC transplants inogona kukonzera matambudziko evascular, senge thrombosis kana embolism, inogona kugura nzvimbo kubva pakuwana ropa.
6. Zvinokonzera kuzvimba: Kurapa kweMSC kunogona kukonzera kuzvimba, izvo zvinogona kuita kuti zvichemo zvetsinga zviwedzere kana kukonzera matambudziko matsva.
Mukupedzisa, mesenchymal stem cell therapy ine mukana wakawanda wekurapa zvirwere zvetsinga, asi zvakakosha kuziva nezve njodzi nemhedzisiro inogona kuuya nazvo. Kuita kuti MSC-based therapies ishande zvirinani uye kuderedza njodzi idzi, kudzidza kwakawanda kunodiwa.
Ndeapi anonyanya kurwara neurological anorapwa ne mesenchymal stem cell therapy?
Aya ndiwo anonyanya kuzivikanwa neurological mamiriro ayo mesenchymal stem cell kurapwa anoshandiswa kurapa:
1. Kukuvara kuBrain, Spinal Cord, uye Peripheral Nerves: Stem cell therapy, iyo inosanganisira mesenchymal stem masero, inoshandiswa kurapa kukuvara kuhuropi, musana, uye tsinga dzeperipheral.
2. Kurohwa: Mesenchymal stem cell therapy yakaratidza kuvimbiswa mukurapa sitiroko, nechinangwa chekubatsira vanhu kupora nekukurumidza uye kuve nemhedzisiro iri nani.
3. Chirwere cheAlzheimer: Panyaya yechirwere cheAlzheimer, tsvagiridzo inoratidza kuti mesenchymal stem masero anogona kubatsira kubata chirwere ichi nekudzivirira neurons nekumisa kufa kwesero nekuburitsa ma cytokines uye zvinhu zvinobatsira.
4. Multiple Sclerosis (MS): Mesenchymal stem masero akaedzwa mukati kliniki miedzo semushonga unobvira weMS, uye zvimwe zvidzidzo zvakaratidza kuti vanogona kubatsira vanhu vane chirwere chetsinga ichi.
Kupfupisa, mesenchymal stem cell kurapwa inowanzoshandiswa kurapa huwandu hwakawanda hwemamiriro etsinga, senge uropi, musana, uye peripheral tsinga kukuvara, pamwe nechirwere cheAlzheimer, multiple sclerosis, uye sitiroko.
Unogona kuda kuverenga: Mesenchymal stem masero (MSC) uye platelet-rich plasma (PRP) kurapwa mukurapa kwemabvi osteoarthritis.
