Kurapa bundu remuuropi kunosanganisira hunyanzvi hwepamusoro uye nzira nyowani nehunyanzvi hwazvino & mishonga inodiwa kurwisa chirwere chinouraya ichi. Chidzidzo chitsva uye nzira yekurapa cancer inoratidza yakanangana nemuviri biological wachi. Makomisheni maviri anonangana nezvinhu zvecircadian wachi anoparadza akati wandei emhando dzemaseru egomarara murabhoritari uye anonotsa kukura kwebundu rehuropi mumakonzo pasina kukanganisa maseru akajairwa.
Iyo Circadian Clock
Iyo circadian wachi iri yakaoma yakaoma yechisikigo inodzora mazuva ese mimhanzi yemuviri wemunhu, semuenzaniso, zororo, tembiricha yemuviri, uye kufanana. Iyo ace "wachi" inzvimbo iri mucerebrum iyo inokanganisa mamiriro ezvisikwa, (semuenzaniso, mwenje) uye inounza dhata kune anobatsira macheki mune akasiyana nhengo.
Zvakare, sero rega mumuviri rine wachi yayo chaiyo inodzora zuva nezuva kutenderera kweakawanda maseru kugona. Zvese kutarisa mumuviri ndezve chikamu chikuru mune yekudyidzana, zvichigonesa iyo fomu yehupenyu kujaira kune yayo mamiriro uye chengetedza kumusoro kwepanyama kuenzana.
REV-ERB mapuroteni ndiwo akakosha zvikamu zvewachi Hardware izvo zvinokunda zvakasikwa masimba ayo maseru ezvirwere anovimba nawo, semuenzaniso, kupatsanurwa kwemasero uye kugaya maseru. Saka Dr. Panda nevamwe vake vakasarudza kuongorora kuti zvinowedzera here izvo zvinoshandura REV-ERBs (inozivikanwa seREV-ERB agonists) inogona kuuraya maseru ekukura nekuvharisa masimba avanofanira kuramba vachikura.
Mumarabhoritari anoedza, vaongorori vakaona kuti maReg-ERB maagonist maviri akauraya marudzi akasiana-siana emaseru (kuverenga pfungwa, colon, uye chipfuva), kunyangwe hazvo maseru aive neshanduko dzekugara nhaka dzinotungamira kukura kwezvirwere. Iwo maReV-ERB agonist haana kuuraya pfungwa dzakasimba kana maseru eganda, ngazvive sezvazvingaite.
Izvi zvakawanikwa zvinokurudzira kuti mishonga inoshandisa REV-ERBs inofungidzirwa inogona kushandiswa kurapa akasiyana siyana marudzi ehuipi, vaongorori vakajekesa.
Vatsvakurudzi vari kugadzira zvinodhaka zvinotanga kana kudzikamisa zvimwe zvedenderedzwa maawa, uye zvinofungidzirwa kuti musanganiswa wemawachi akasiyana-siyana anotarisana nemishonga kana wachi-inotarisana nemishonga ine dzakasiyana mhando yekurapa inogona kugadzirisa anticancer kukanganisa. Chero zvazvingaitika, izvozvi, pane huwandu hukuru hwekubvunza pane mhinduro.
