Numutkeun Jabbar et al. Tina Universitas Gothenburg di Swédia, spéktrometri massa sasaran dumasar kana ukur tilu biomarker cairan kista tiasa sacara akurat ngaidentipikasi sareng ngaevaluasi. kamungkinan tina kista pankréas ngembang kana kanker pancreatic . Éta patut ngalaksanakeun panilitian sanés pikeun ngonfirmasi naha metode ékspérimén ieu tiasa ngabantosan dina diagnosis kanker dina waktosna, suksés ngahalangan sareng nyegah kanker. (J Clin Oncol. Versi online 22 Nopémber 2017)
Cystic lesions of the pancreas are very common in imaging, and about half are kanker pancreatic lesions. Therefore, accurate and specific diagnosis is essential for the correct treatment of patients. Unfortunately, the currently used diagnostic methods cannot effectively distinguish between pancreatic precancerous lesions and malignant pancreatic cystic lesions.
Para panalungtik ngagunakeun sampel cairan kista diala ku puncturing handapeun hidayah endoscopy ultrasound konvensional pikeun analisis. Dina ulikan kohort 24 pasien, metode biologi protéin éksplorasi ngaidentipikasi 8 calon biomarker anu tiasa masihan inpormasi ngeunaan transformasi ganas sareng displasia kelas luhur / parobahan kanker. Salajengna, analisa kuantitatif 30 péptida dilabélan sareng spéktrométri massa ngawaskeun réaksi paralel dilaksanakeun dina 80 pasien dina set data sareng 68 pasien dina set verifikasi. Titik ahir ulikan éta hasil tina diagnosis patologi bedah atanapi tindak lanjut klinis.
The results show that the best markers for malignant tumors may be a group of peptides derived from MUC-5AC and MUC-2. These markers can identify precancerous lesions / malignant lesions from benign lesions. The accuracy is as high as 97%. Compared with the cystic liquid carcinoembryonic antigen and cytological detection of these standard identification methods, the accuracy of these standard methods is 61% (95% CI 46% ~ 74%, P <0.001) and 84% (95% CI 71% ~ 92%, P = 0.02). MUC-5AC combined with prostate stem cell antigen can identify high-grade dysplasia or cancer, with an accuracy of 96%, can detect 95% of malignant lesions or severe dysplasia, and the detection rate of carcinoembryonic antigen and cytology 35% and 50% respectively (P <0.001, P = 0.003).
