Vanotsvaga pa Chirangaridzo Sloan Kettering Cancer Center uye Massachusetts Institute of Technology vakagadzira hurongwa hutsva hutatu hunoshandisa mishonga yenyukireya kunanga uye kubvisa colorectal cancer. Vatsvagurudzo vakawana 100% yekurapa mwero mune yemhando yegonzo uye havana kana huturu hwakanangana nehutano. Chirevo chekutsvaga chakaburitswa munaNovember Chinyorwa cheNyukireya Mishonga.
Parizvino, radioimmunotherapy (yakanangwa kurapa) ichishandisa radionuclides-yakanangana neanorwisa muviri kurapa mamota akasimba ane mashoma mashandiro. “Ichi chidzidzo chenganonyorwa. Irosi yechipiri isina chepfu inosvika munyama dzomuviri womunhu pakurapa bundu. ” Steven m. Larson naDr. Sarah Cheal vakatsanangura, "Kubudirira kweiyo mbeva bundu modhi kunobva muchikwata Hunhu hwakasarudzika hwemagadzirirwo akaitiswa, kune rumwe rutivi, zvinobva munzira dzakadzikiswa dzekudzidzira, kusanganisira nzira yekurapa yekuongorora iyo inogona kuendeswa nyore nyore varwere. “Nzira iyi inoshandisa mushonga mumwe chete kuongorora nekurapa zvirwere. Mushonga uyu unotanga wawana cancer maseru uye wozoaparadza kuitira kuti maseru ane hutano arege kukuvadzwa. Nenzira iyi, mhedzisiro inodzikiswa uye hupenyu hwemurwere hunovandudzwa.
In this study, glycoprotein A33 (GPA33) was used to recognize A33 tumor antigen. DOTA-pretargeted radioimmunotherapy (PRIT) was tested on a mouse model. For randomly selected test mice, SPECT / CT imaging was used to monitor the treatment response, and the radiation absorbed dose of the tumor was calculated. The tested mice responded well. None of the evaluated mice showed signs of cancer under the microscope, and no significant radiation damage was seen in key organs including bone marrow and kidney.
Iyo 100% yekurapa mwero mune yegonzo modhi ndiko kugamuchirwa kwekutsvaga, zvichiratidza kuti anti-GPA33-DOTA-PRIT ichave iri inoshanda radioimmunotherapy regimen yeGPA33-yakanaka kenza yakajeka kenza.
Sekureva kweCDC, gomarara rakasarudzika ndiyo gomarara rechitatu rinonyanya kubata varume nevakadzi. MuUnited States, mune vangangoita zviuru zana nemakumi mana zvezviitiko gore rega rega uye kufa kwevanhu zviuru makumi mashanu.
Larson naCheal vanotenda kuti kana kiriniki ikabudirira ikawanikwa, iyi yenyukireya kurapwa inogona kuwedzerwa kune mamwe kanzira. Iyo sisitimu yakagadzirirwa se "plug uye play" system iyo inogona kugamuchira akasiyana ma antibodies kurwisa munhu bundu maantigen, uye iri musimboti rinoshanda kune ese akasimba uye emota mamota mumuviri wemunhu. Vakawedzera kuti "munda we oncology, kunyanya mamota akasimba akasiyana anosanganisira colon, zamu, pancreas, melanoma, lung uye ezophagus, pane kudiwa kukuru kwekurapa chirwere chemberi."
