Nekuti kenza yechiropa ine marudzi mazhinji, nhaka yakasimba, uye nyore kudzokorora, kuzivisa biomarkers inogona kufanotaura kufambira mberi kwechirwere ndicho chinangwa chakakosha mukurwisa cancer yechiropa.
Munguva pfupi yapfuura, vaongorori vakagadzira nzira yekuziva iyo yakajairika kenza yechiropa gomarara-hepatocellular carcinoma (HCC) yakavakirwa pakupatsanura biomarkers. Ivo vanotenda kuti nzira iyi inogona zvakare kushandiswa kune mamwe marudzi ekenza. Ichi chidzidzo chinoratidzira mashandiro anoita RNA akasiyana maringe nekenza, uye inonongedza kuti aya akasiyana anogona kuve anogona biomarkers ekuwedzera kenza.
Kutsemura kunoreva maitiro ekuti RNA ruzivo rwunoteedzerwa kubva kune ruzivo rwakanyorwa mujeni inogadziriswa isati yashandiswa kugadzira mepuroteni mepu. Jini rinogona kuburitsa akawanda maRNA mameseji, uye meseji yega yega inogadzira akasiyana mapuroteni musiyano kana "isomer." Zvirwere zvakawanda zvine hukama nezvikanganiso kana misiyano muRNA nzira dzekutsikisa. Zvikanganiso kana shanduko mukutsemura zvinogona kukonzera mapuroteni ane akasiyana kana asina kujairika mabasa.
Recent research has identified splicing irregularities in gomarara rechiropa cells. Krainer’s team has developed a method that can comprehensively analyze all RNA information produced by a given gene. The team tested their methods of detecting splice variants in HCC by analyzing RNA information from HCC cells collected from hundreds of patients.
They found that the specific splicing isoform of the AFMID gene is associated with the patient’s low survival. These variants result in cells making truncated versions of the AFMID protein. These unusual proteins are associated with mutations in TP53 and ARID1A tumarara suppressor genes in adult liver cancer cells.
Vatsvagiri vakafungidzira kuti shanduko idzi dzine chekuita neiyo yakaderera mwero wemorekuru inonzi NAD +, inobatanidzwa mukugadzirisa DNA yakakanganisika. Kugadzirisa AFMID splicing inogona kutungamira mukuwedzera kugadzirwa kweNAD + uye kuwedzera DNA kugadzirisa. Kana tikakwanisa kuita izvi, kusona kweAFMID kunogona kuve kwakanangana nekurapa uye sosi yemishonga mitsva yegomarara rechiropa. Kuedza kwekutanga kunoratidza kuti tsvakiridzo yechikwata iri munzira chaiyo, uye isu tinotarisira zviri nani data zvabuda kubatsira varwere vekenza yechiropa.
