Scientists at the University of California, San Francisco have discovered a common genetic driver of aggressive meningioma, which can help clinicians detect this dangerous cancer earlier and find new treatments for these difficult-to-treat tumors. A research team led by Dr. David Raleigh found that increased gene activity called FOXM1 seems to be responsible for the aggressive growth, and these tumors frequently relapse.
To investigate the factors that may lead to aggressive meningioma, Raleigh’s team collected 280 human meningioma samples from 1990 to 2015. Using a range of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these tumor and patients’ clinical outcomes. Finally, a gene called FOXM1 was found to be the core of the growth of invasive meningioma, and also an indicator of the subsequent adverse clinical outcomes, including death.
Para panaliti ogé mendakan hubungan anyar antara sumebarna meningiomas agrésif sareng aktivasina jalur signalling antar-selular, anu disebut Wnt, anu biasana ngagaduhan peran dina pamekaran émbrionik sareng pembentukan jaringan. Nunjukkeun yén protéin anu dihasilkeun ku FOXM1 tiasa ngirimkeun sinyal sapanjang jalur Wnt, data anu anyar nunjukkeun yén gawé koperasi jalur FOXM1 sareng Wnt tiasa nyababkeun sumebarna meningiomas salajengna. Hypermethylation tiasa janten pemicu mimiti pikeun pembentukan meningiomas agrésif.
Raleigh nyarios yén padamelan pikahareupeun kedah milarian terang mana gén FOXM1 ngaktipkeun pikeun ngajalankeun pertumbuhan meningioma, sareng ngahalangan target ieu ku terapi klinis. Diharepkeun bakal aya ubar pikeun ngeureunkeun patogénesis tumor otak dina jalur ieu gancang-gancang sareng nguntungkeun seuseueurna pasien kanker.
