Yunivhesiti yeAthens Strati A et al. yakashuma kuti kana PD-L1 yakanyanyisa mukutenderera bundu masero (CTC) inogona kupa ruzivo rwakanyanya uye rwakakosha rwekufungidzira kune varwere vane musoro nemutsipa squamous cell carcinoma. Mushure mekurapwa, varwere vane PD-L1 yakanaka muCTC vachiwana adjuvant PD1 kudzvinyirira kurapwa vanokodzera kuongororwa. (Ann Oncol. 2017; 28: 1923-1933.)
Based on the tumor’s biological markers, it can be determined whether PD 1 checkpoint inhibitors may ultimately benefit some patients with musoro nomutsipa squamous cell carcinoma. The molecular characteristics of circulating tumarara cells are critical for studying targeted therapy of tumors, and the biomarkers that predict PD 1 checkpoint inhibitors are still unclear. This prospective study included a group of patients with head and neck squamous cell carcinoma who were being treated to evaluate whether circulating tumor cells that overexpress PD-L1 can be detected at baseline (before treatment) and at different treatment time points to predict treatment After the clinical effect.
Vatsvakurudzi vakagadzira yakanyanyisa uye yakananga RT-qPCR kit yekuona PD-L1 mRNA kutaura muEpCAM-positive CTC masero. Chidzidzo chacho chakanyoresa varwere ve113 vane nzvimbo yepamusoro yepamusoro uye mutsipa squamous cell carcinoma uye vakaona PD-L1 kutaura muEpCAM-positive CTC masero pakutanga, mushure me 2 cycles of induction chemotherapy (masvondo matanhatu), uye mushure menguva imwechete chemoradiation (masvondo gumi nemashanu) Level.
Mhedzisiro yacho yakaratidza kuti pakutanga, 25.5% (24/94) varwere vaive nePP-L1 overexpression mumaCTC avo. Chiyero chekuwedzererwa mushure mekudzidziswa chemotherapy yaive 23.5% (8/34), uye 22.2% (12/54). Mushure mekurapwa, varwere vane CTC vachiri kunyanya kufungidzira PD-L1 vaive nehupenyu hupfupi-hwekuenderera-husina kurarama (P = 0.001) uye kupfupika kwehupenyu hwese (P <0.001).
Mushure mekurapwa, PD-L1 isina kunyanya kufungidzira inogona kuita mukana wekuwana kuregererwa kwakazara (OR = 16, 95% CI 2.76 ~ 92.72; P = 0.002).
