Tsvagiridzo nyowani yakawana kuti pancreatic cancer maseru anovimba zvakanyanya neprotein kukura nekupararira. Mhedzisiro yekutsvagisa inogona kuunza nzira nyowani dzekurapa nekudzivirira kwepancreatic cancer.
IAmerican Cancer Society inofungidzira kuti inosvika makumi matanhatu neshanu evarwere vane gomarara repashure repancreatic vanogona kurarama kweanenge makore mashanu mushure mekuongororwa. Asi mamwe pancreatic cancer subtypes ane hasha. Semuyenzaniso, kana ukaonekwa kuti une pancreatic ductal adenocarcinoma, kazhinji inenge yatova padanho repamusoro uye mwero wayo wemakore mashanu wekurarama uri pasi pegumi muzana. Nekudaro, kutsvagurudza kutsva kwakaratidza kusasimba kukuru kweiyi kenza ine hutsinye, kureva kuti pancreatic cancer maseru anopindwa muropa neprotein yakakosha. Muchidzidzo ichi chitsva, Dr. Christopher Vakoc, purofesa paCold Spring Harbour Laboratory muNew York, nechikwata chake vakawana geni rinovhara puroteni inonyanyisa kurwisa mukenza yepancreatic. Iyo postdoctoral shamwari muPurofesa Vakoc's rabhoritari. Muongorori Timothy Somerville ndiye munyori anotungamira, uye bepa rakaburitswa munguva pfupi yapfuura mumagazini Cell Report.
Somerville akatsanangura kuti vanhu vanoonekwa kuti vane kenza yepancreatic vanogona kurarama avhareji yemakore maviri. Zvisinei, avo vane pancreatic ductal adenocarcinoma vane hupenyu husingagutsi. Vatsvagiri veboka raPurofesa Vakoc vakafungidzira kuti puroteni chaiyo inogona kukonzera kenza iyi kuva nehasha. Vatsvagiri vakaenderera mberi nekudzidza protein TP2 vachishandisa tsika dzakabva kune yakajairika pancreatic tishu kana pancreatic ductal adenocarcinoma. Ongororo iyi yakaratidza kuti kuvepo kweTP63 mune bundu kwakabvumidza maseru egomarara kukura, kuwanda uye metastasize kune mamwe mativi emuviri. .
Somerville akatsanangura kuti chimwe chezvinhu zvinokurudzira zvakawanikwa ndechekuti maseru egomarara anovimba neP63 kuti irambe ichikura. Naizvozvo, tiri kuongorora kuvharirwa kweP63 chiitiko senzira yekurapa yevarwere. "Saka, kunzwisisa kuti sei P63 gene inoshanda mune vamwe vanhu ichaburitsa akakosha matanho ekudzivirira anogona kubatsira zvakanyanya mukurarama kwegomarara repancreatic."
