Vatsvagiri paUniversity yeCalifornia, San Francisco uye St. Jude Vana Chipatara Chekutsvagisa muTennessee vakagadzirisa zvakavanzika zvekurapa makumi emakore apfuura, uye vakawana paine majini ekuchinja anogona kukonzeresa zvirwere zvemhuri neropa uye kunyange leukemia. Chidzidzo ichi chakanangana nekuongororwa kweDNA kwevakoma nevanun'una gumi nevatanhatu mumhuri shanu, zvichiratidza kuti vamwe vana vane majenasi vachazvigadzirira vega, uye vakawanawo mamwe mamaki emageneti ayo anobatsira vanachiremba kunzvenga kupinza uye kuisa njodzi yemongo wemapfupa.
Matambudziko akapoteredza chirwere ichi anogona kurondwa kumashure anopfuura makore makumi matatu apfuura, apo oncologist Kevin Shannon, MD, weYunivhesiti yeCalifornia, San Francisco, uye vaaishanda navo vakasangana nemhuri dzinoverengeka, dzakawanda dzadzo dzinogona kunge dziine masero eropa mashoma (abnormal myelodysplastic). Syndrome) Chiratidzo kana MDS) uye acute myeloid leukemia (AML), gomarara reropa rakaipisisa uye rinouraya. Varwere ava vane imwe panzvimbo yemakopi maviri echromosome 30, inonzi single chromosome 7.
The data shows that mutations in the genes SAMD9 and SAMD9L located on chromosome 7 are closely related to single chromosome 7 syndrome, but many healthy siblings and patients’ parents also carry these mutations without any symptoms. Researchers have shown that patients who do have symptoms of MDS and AML also have a specific secondary gene mutation, which can drive a more serious disease, and patients without these additional mutations often never experience any symptoms and may develop blood. The count is low but most can recover on their own without treatment.
Kuchinja kwemajini pakromozomu 7 kunowanzoitika muvarwere vane AML neMDS, uye mapundu akaipa ekromozomu imwe chete 7 anobatanidzwa nekusaziva fungidziro uye haapindure zvakanaka kumishonga iripo. Neanopfuura mazana masere nemakumi matanhatu emajini pachromosome 860, zvichave zvinonakidza kunzwisisa basa reSAMD7 neSAMD9L mune isiri-yemhuri MDS neAML uye mabatiro avanoita nemamwe majini pakromosome 99.
